Showing papers in "European Journal of Cell Biology in 2010"

TL;DR: This work quantitatively analyzed cell morphology and the response to the laser ablation of cell bonds in the vicinity of the anteroposterior compartment boundary in developing Drosophila wings and provides a physical mechanism in which the local increase in Myosin II-dependent cell bond tension directs cell sorting at compartment boundaries.

TL;DR: Polysaccharide intercellular adhesin (PIA) is the best studied factor involved in S. epidermidis biofilm accumulation and might represent a more general pathogenicity principle in biofilm-related infections.

TL;DR: A comprehensive survey of plant immunity-related RLK gene expression is provided and a role of the Arabidopsis Brassinosteroid Insensitive 1 (BRI1)-associated receptor kinase 1 (BAK1) is proposed as an adaptor molecule that is required for proper functionality of numerous RLKs.

TL;DR: The subcellular dynamics of auxin transport proteins represents an important interface between cellular processes and development of the whole plant and is summarized in this review.

TL;DR: One important member of this family, WRKY53, is tightly regulated by different unexpected mechanisms and is a convergence node between senescence and biotic and abiotic stress responses.

TL;DR: The hypothesis that keratinocytes are not only static bricks of the epidermal wall, but immunologically active cells critically involved in different (auto)-inflammatory (skin) diseases is discussed.

TL;DR: It is demonstrated for human skin that occludin- and claudin-1-positive sites in the stratum granulosum form a barrier for extracellular biotin-SH (557Da) and that in psoriatic skin the localization of the barrier and the TJ proteins are altered in parallel.

TL;DR: Focus will be given on the mounting evidence deciphering key developmental brain functions for Sirtuins in neuronal motility, neuroprotection and oligodendrocyte differentiation and functions of the unconventional family member SIRT2 in post-mitotic neurons and glial cells.

TL;DR: The generation of recombinant single-chain antibody fragments against M6P residues and of new mouse models of MLII and MLIII will have considerable impact to provide deeper insight into the cell biology of lysosomal dysfunctions and the pathomechanisms underlying these lysOSomal disorders.

TL;DR: It is shown that the expression of ARR7, WUS and CLV3 is dependent on cytokinin signalling, and loss-of A-type ARR function in arr7 and arr3,4,5,6,7,8,9 mutants strongly stimulated callus development, indicating that cell proliferation is repressed by A- type ARRs.

TL;DR: Gene knockdown of CAXII in the human breast cancer cell line MDA-MB-231 resulted in decreased invasion and migration by interfering with the p38 MAPK pathway, and results showed thatCAXII knockdown may decrease anchorage-independent growth and cell growth by inhibiting CDK6 and cyclin D1 expression.

TL;DR: The aim of this review is to summarize the current knowledge on the indole-3-acetamide (IAM)-dependent pathway of IAA production in plants and to discuss the properties of the involved proteins and genes, respectively.

TL;DR: Results demonstrate that expression of Cx43 augments migration via modulation of p38 MAP kinase activity, which plays an essential role in this signalling pathway which is independent of gap junction function.

TL;DR: Data support the long-standing hypothesis that the switch from a histone- to protamine-based chromatin protects the paternal genome from mutagens.

TL;DR: This review focuses on the biosynthetic pathways and the significance of PC in bacteria with an emphasis on plant-microbe interactions.

TL;DR: The description of invadopodial structures on a dermis-based matrix should greatly aid the development of new criteria for the identification of invADopodia in vivo, and opens up the possibility of studying the invadobodia-related signaling in a more physiological environment.

TL;DR: It is shown that human umbilical vein endothelial cells (HUVEC) express only talin 1, and that talin1 knockdown inhibited focal adhesion (FA) assembly preventing the cells from maintaining a spread morphology, a phenotype that was rescued by GFP-mouse talin2.

TL;DR: Functional interactors include a set of sigma binding proteins that confer enhanced promoter binding in vitro and are thought to be involved in pathogenic stress responses of the chloroplast in vivo.

TL;DR: Evidence is provided that the activity and localization of mouse formin mDia1 can be regulated through interactions with phospholipids and the N-terminalospholipid-binding sites help to anchor formins at the plasma membrane, and the interaction with phosphorus in the C-terminus functions as a switch for transient inactivation.

TL;DR: The data suggest that the signaling specificity through PKA in yeast could be mediated by a particular subcellular localization of each isoform of Tk, with the peculiarity that Tpk2 and Tk3 but not Bcy1, were found associated to P-bodies and EGP bodies.

TL;DR: It is now generally accepted that NHR of Arabidopsis to powdery mildews comprises two distinct layers of defence: pre-invasion entry control at the cell periphery and post-Invasion resistance based on cell death execution.

TL;DR: An update on recent advances in understanding the function of ferredoxins and the hydrogenase in C. reinhardtii is given.

TL;DR: It is concluded that myopodin is a multiadapter protein of the sarcomeric Z-disc that links nascent myofibrils to the sarcolemma via zyxin, and might play a role in early assembly and stabilization of the Z- Disc.

TL;DR: Experimental Mtb infections in mice transgenic for human DC-SIGN revealed that, instead of favoring immune evasion of mycobacteria, DC-ALSE may promote host protection by limiting tissue pathology, and infection studies with myCobacterial strains genetically engineered to lack manLAM or PIMs demonstrated that the manL AM/PIM-DC-SIGN interaction was not critical for cytokine secretion in vitro and protective immunity in vivo.

TL;DR: Different itineraries for the retrograde transport of Shiga toxin and TGN38 and distinct retromer components that regulate the transport of these cargos are identified, suggesting distinct routes for each cargo.

TL;DR: It is shown that a hybrid technique, based on a combination of cryofixation/freeze-substitution and Tokuyasu cryosection immunolabelling, circumvents the disadvantages associated with chemical fixation and results in an improved ultrastructure and antigenicity preservation of Tokuyatu cryosections used for light and electron microscopic immunolABelling.

TL;DR: It could be demonstrated that CSN function and deneddylation are required but not essential for CRL-mediated processes, and models for the role of neddylations and denedylation in controlling CRL activity are emerging.

TL;DR: This review focuses on pattern recognition receptors in plants that detect extracellular signals indicative for pathogen attack and injury and starts out with a discussion on FLS2, which binds and responds to bacterial flagellin.

TL;DR: Fluorescence fusion proteins in living cells are studied to show that galectin-3 accumulates intracellularly in acidified endosomes, and these endosomal organelles are candidate compartments for the association between galectIn-3 and exocytic apical cargo.

TL;DR: It is demonstrated that 3O-C(12)-HSL can induce changes in calcium signalling through influx and release of calcium from thapsigargin-sensitive stores and delocalization of inositol 1,4,5-trisphosphate receptors (IP(3)R), but not of ryanodine receptors (RyR), and that bacterial quorum sensing signals represent inter-kingdom signalling.