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JournalISSN: 0009-4374

European Journal of Medicinal Chemistry 

Elsevier BV
About: European Journal of Medicinal Chemistry is an academic journal. The journal publishes majorly in the area(s): Antibacterial agent & Docking (molecular). It has an ISSN identifier of 0009-4374. Over the lifetime, 13535 publications have been published receiving 378733 citations.

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Journal ArticleDOI
TL;DR: This Review Article is focused on the action of the reactive oxygenated species in inducing oxidative injury of the lipid membrane components, as well as on the ability of antioxidants (of different structures and sources, and following different mechanisms of action) in fighting against oxidative stress.

1,667 citations

Journal ArticleDOI
TL;DR: This review highlights recent developments in the synthesis of functionalized 3,4-dihydropyrimidin-2(1H)-ones with a focus on the DHPMs recently developed as calcium channel modulators, alpha(1a) adrenoceptor-selective antagonists and compounds that target the mitotic machinery.

1,191 citations

Journal ArticleDOI
TL;DR: This review is complementary to earlier reviews and covers more recent reports of antimicrobial activity of chalcones (antibacterial and antifungal), as well as antileishmanial, antimalarial, antiviral and anti-inflammatory activities of these compounds.

956 citations

Journal ArticleDOI
TL;DR: A modification of the parallel artificial membrane permeation assay (PAMPA), developed with 30 structurally diverse commercial drugs and validated with 14 Wyeth Research compounds, has the advantages of predicting passive blood-brain barrier penetration with high success, high throughput, low cost, and reproducibility.

929 citations

Journal ArticleDOI
Claude Monneret1
TL;DR: Design of a second generation ofHDACs was based upon data affording potent HDACs such as LAQ824 and PDX101 currently under phase I clinical trials, and two of them, MS-275 and CI-994, have reached phase II and I clinical Trials, respectively.

819 citations

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