Showing papers in "European Journal of Pharmaceutical Sciences in 2013"

TL;DR: An overview of available nanoscale drug carriers is provided by exploring the wide variety of developed nanostructures and the most commonly used moieties for targeted delivery by examining tumor physiology and the specific barriers present within both the tumor microenvironment and systemic delivery.

TL;DR: TPGS properties as a P-gp inhibitor, solubilizer/absorption and permeation enhancer in drug delivery and TPGS-related formulations such as nanocrystals, nanosuspensions, tablets/solid dispersions, adjuvant in vaccine systems, nutrition supplement, plasticizer of film, anticancer reagent and so on are discussed.

TL;DR: Recent and future developments for MN technology including the latest type of MN design, challenges and strategies in MNs development as well as potential safety aspects based on comprehensive literature review pertaining to MN studies to date are focused on.

TL;DR: This review presents aptamers in on-going, completed, and terminated clinical studies highlighting their mechanism of action as well as the inherent challenges of aptamer production and use.

TL;DR: It is concluded that piplartine is effective for use in cancer therapy and its safety using chronic toxicological studies should be addressed to support the viability of clinical trials.

TL;DR: Encouraging results confirmed the development of a novel non-invasive nose to brain delivery system of BRC for the treatment of PD.

TL;DR: The highest dissolution rate and supersaturation of poorly water soluble drugs could be attributed to drug-polymer interactions occurred during HME.

TL;DR: It is shown that beclomethasone dipropionate (BDP) nanoparticles coated with amphiphilic hydrophobin proteins can be well integrated into the NFC aerogels and modulation of the matrix formers enable a control of the drug release rate.

TL;DR: Viable excised human intestine mounted in the Ussing chamber, is a powerful technique for predicting regional fraction absorbed (f(a), transporter-mediated uptake or efflux as well as intestinal metabolism of drug candidates in man.

TL;DR: Biopharmaceutical assessment approaches that rely on the amount of molecularly dissolved drug should guide us towards successful enabling formulations, as recent in vitro data indicate, that commonly employed surfactant as well as endogenous surfactants present in the intestine, although enhancing drug solubility, mostly hamper drug permeation.

TL;DR: From this study, logP and enthalpy were concluded to have a direct correlation on the feasibility of formation of a stable nanosuspension.

TL;DR: The performance of GI-Sim was shown to be suitable for early risk assessment as well as to guide decision making in pharmaceutical formulation development and to be able to predict the increase in absorption and plasma exposure achieved with nanoformulations.

TL;DR: In this review, in vitro, in vivo and ex vivo models that have been extensively used to study the behaviors of airborne particles in the lungs and determine the absorption of drugs after pulmonary administration are discussed.

TL;DR: It was concluded that solid lipid nanoparticles incorporated Carbopol gel had skin targeting ability and may serve as a promising carrier in treatment of fungal skin infections.

TL;DR: Epirubicin-5TR1 aptamer-SPION tertiary complex is introduced as an effective system for targeted delivery of Epi to C26 cells and could efficiently detect tumors when analyzed by MRI and inhibit tumor growth in vivo.

TL;DR: The NLC system showed the highest improvement in topical delivery of quercetin manifested by the amount of quERCetin retained in full thickness human skin, compared to a control formulation with similar composition and particle size in the micrometer range.

TL;DR: It is shown here, for the first time, that mAbs of the IgG₄ subclass behave similar as the other subclasses, and is a useful prediction tool in the determination of solution conditions that favors low solution viscosity at high protein concentration of therapeutically used mAb molecules.

TL;DR: The challenges and potential uses of nanodelivery system for the topical drug therapy of vaginal diseases, as well as the controversies related to mucoadhesiveness of nanopharmaceuticals are summarized.

TL;DR: It is demonstrated that an NIR instrument capable of fast spectra acquisition can be a valuable tool for the in-line monitoring of the continuous mixing and tableting processes.

TL;DR: The physical methods that have been used to either transiently perturb the skin barrier or to provide additional driving forces to facilitate molecular transport are reviewed with a particular focus on technologies that have either led to marketed products or have at least reached the clinical development stage.

TL;DR: Permeation through sheep nasal mucosa using in situ gel demonstrated a harmless nasal delivery of venlafaxine, providing new dimension to the treatment of chronic depression.

TL;DR: The selectively fungicidal characteristics and ability to restore FLC susceptibility in resistant isolates signify a promising candidature of THY and CARV as antifungal agents in combinational treatments for candidiasis.

TL;DR: Findings have the potential to rationalize decisions schemes for utilizing and developing amorphous formulations, through early predictions of glass-forming ability from Mw and physical stability from simple DSC characterization.

TL;DR: Investigation of the ability of inorganic salts to improve the dissolution rate of carbamazepine from tablets containing a high loading of a Soluplus®-based solid dispersion demonstrated the utility of including salts in tablets to improve dissolution properties.

TL;DR: Several loading processes in terms of drug distribution throughout the mesoporous silica matrix, drug solid state form and drug release properties resulted in enhanced drug release compared to the unprocessed drug with the impregnation, liquid and SC-CO₂ producing the greatest increase at t=30 min.

TL;DR: The reduction of particle size resulted in a more rapid dissolution of AP from nanocrystals than from coarse powder, which exhibited a significantly decreased t(max), a 3.6-fold higher peak plasma concentration (C(max)), and 3.4- fold higher area under the curve (AUC) in comparison to coarse powder.

TL;DR: The in vivo performance of self-nanoemulsifying drug delivery systems (SNEDDSs) with different in vitro physicochemical properties were determined, and the area under the colloidal dispersion curves as well as under the lipolysis curves could be used to rank order the in vitro performance of the SNED DSs.

TL;DR: Results demonstrate that this novel microparticulate/nanoparticulated chemotherapeutic PEGylated phospholipid dry powder inhalation aerosol platform has great potential in lung cancer drug delivery.

TL;DR: Findings suggest that DHA-doxorubicin-loaded SLN is a promising alternative for the treatment of cancer, and the improved cellular uptake achieved with the drug encapsulation can be an explanation.

TL;DR: The results demonstrate that glycerol and urea can retain high steady state flux of Mz across skin membranes at dehydrating conditions, which otherwise would decrease the permeability due to dehydration.