Showing papers in "European Journal of Pharmaceutics and Biopharmaceutics in 2000"

TL;DR: The aim of this article is to present a concise review on the applications of hydrogels in the pharmaceutical field, hydrogel characterization and analysis of drug release from such devices.

TL;DR: Relevant issues for the introduction of SLN to the pharmaceutical market, such as status of excipients, toxicity/tolerability aspects and sterilization and long-term stability including industrial large scale production are discussed.

TL;DR: The historical background and definitions of the various systems including eutectic mixtures, solid dispersions and solid solutions, as well as the production, the different carriers and the methods used for the characterization of solid dispersion are outlined.

TL;DR: An overview of the biopharmaceutics drug classification system (BCS), which enables the regulatory bodies to simplify and improve the drug approval process and can also be utilized by the formulation scientist to develop a more optimized dosage form.

TL;DR: A review of recent progress in the field of nanoparticle uptake from this site of administration examines recent progress with nanoparticles consisting of a novel class of charged comb polyesters, poly(2-sulfobutyl-vinyl alcohol)-graft-poly(D,L-lactic-co-glycolic acid), SB-PVAL-g-PLGA, allowing adjustment of physicochemical nanoparticle properties with a single class of polymers.

TL;DR: The data obtained indicated that macromolecular therapeutics activated different signaling pathways and possessed a different mechanism of action than free drugs, which bodes well for the success of future research aimed at identification of new intracellular molecular targets.

TL;DR: Enhanced retinol palmitate uptake should derive from specific SLN effects and is not due to non-specific occlusive properties, as Transepidermal water loss (TEWL) and the influence of drug free SLN on retinyl palmitates uptake exclude pronounced Occlusive effects.

TL;DR: This review outlines SDLFs as one of the most promising approaches to overcome the formulation difficulties of these hydrophobic/lipophilic drugs.

TL;DR: The water Swelling and drug diffusion from initially hydrophilic, glassy polymer matrices were modeled using concentration-dependent diffusion equations for water and drug using an appropriate boundary condition incorporating a relaxation-dependent Deborah number.

TL;DR: There are insufficient comparative data to support any of the local delivery system for antibiotherapy, and local delivery of antimicrobial agents using controlled release systems should be considered as adjunctive to mechanical debridement for the treatment of localized forms of periodontal destruction.

TL;DR: This review intended to revisit microsphere-based vaccines designed for the parenteral route and attempted to outline major developmental issues, as well as to analyze immunological fundamentals and data associated with antigen delivery by microspheres.

TL;DR: Although the particle size changes induced by NP lyophilization were slight, they need to be carefully evaluated and cannot be neglected.

TL;DR: The method of choice in this study, melt extrusion, proved to overcome many of the shortcomings of conventional methods and achieve a significant increase in dissolution rate when compared to the pure drug or to the physical mixtures.

TL;DR: Two types of alginate gel beads capable of floating in the gastric cavity were prepared and their release properties are applicable not only for sustained release of drugs but also for targeting the Gastric mucosa.

TL;DR: Laminates containing gel layers prepared after 3 or 5 cycles were successfully prepared with good stability over a 6 month swelling period and could be used to achieve zero-order release behavior in novel, freeze/thawed PVA laminates.

TL;DR: In an animal model,microspheres obtained from polymer or microsphere blends attained a faster onset of testosterone suppression as compared to microspheres from higher molecular weight 50:50 hydrophilic PLGA polymer, 28.3 kDa, alone, which illustrated the feasibility of blending polymers or micro spheres of varied characteristics in achieving modified drug release.

TL;DR: The potential of confocal laser scanning microscope (CLSM) has been evaluated for characterizing microcapsules and it was proved that fluorescence labelling did not alter physico-chemical properties critical to the encapsulation process.

TL;DR: A preliminary investigation of the physical stability of the myoglobin revealed that the alpha-helical structure was unaffected by the formulation, process, and the storage conditions.

TL;DR: It is demonstrated that polysorbate 80 coated poly(butylcyanoacrylate) nanoparticles used so far as a delivery system to the brain for drugs that do not freely penetrate the blood brain barrier can also be used as a parenteral controlled release system to prolong the CNS availability of drugs that have a short duration of action.

TL;DR: This review discusses the use of cationic lipids, protein and peptide delivery agents, and several novel chemical and viral methods that have recently been explored as delivery vehicles, focussing not only on their strengths, but also on their limitations.

TL;DR: This animal model may be helpful in evaluating the biopharmaceutics of drugs exhibiting pH-dependent dissolution or decomposition in fasted beagle dogs.

TL;DR: Factors affecting in-line near infrared moisture measurement with a four-wavelength sensor were evaluated (choice of binder used in granulation liquid and the increase in particle size) and should be considered when choosing NIR wavelengths used for detection of water with a fixed wavelength set-up.

TL;DR: To develop new formulations that have suitable bioadhesion force and provide sustained release in buccal area for an extended period of time, bioadhesive gels containing triamcinolone acetonide were prepared using two polymers, carbopol 934 and poloxamer 407 which were selected for their bioadhesiveness and gelling property.

TL;DR: Ten strains of lactobacilli were evaluated for the administration of viable microorganisms to restore the normal indigenous flora in the treatment of urogenital tract infections (UTI) in women, and three out of ten strains appear particularly suitable for their application in the Treatment of UTI.

TL;DR: In this article, the authors analyzed the tensile strength of a well and a poorly compactable substance in a tablet mixture and proposed two power laws for percolation in a comparatively low pressure range.

TL;DR: Sch 56592, Sch-X and Sch-Y are low solubility-high permeability compounds under the BCS guidance, and for such poorly water-soluble NCEs, solubilizing excipients should be carefully screened based on their effects onsolubility profiles and membrane transport.

TL;DR: Droplet size was dependent on the homogenization pressure and the polymer content, and differences were found between emulsions stabilized with higher and lower molecular weight HPMC.

TL;DR: Poly(ortho ester) IV can be easily prepared in a highly reproducible manner, is very stable provided moisture is rigorously excluded and has also been shown to be highly biocompatible.

TL;DR: The results show that an up-scaling of the encapsulation of protein vaccines or drug by spray-drying is feasible, but that additives, the type of polymer solvent, the polymer concentration, the w/o ratio and the product collection method influence process and product quality.

TL;DR: A highly effective drug carrier system for biotinylated compounds such as PNAs was achieved since the formation of the interaction between biotin and avidin is very rapid and stable.