Showing papers in "European Journal of Pharmaceutics and Biopharmaceutics in 2002"

TL;DR: Improved bioavailability was achieved again demonstrating the value of the technology as a drug delivery tool, with particular advantages over solvent processes like co-precipitation.

TL;DR: For the first time it was possible to show plasma protein adsorption patterns on a range of nanoparticles with variation of only one parameter, i.e. the charge, while size and surface hydrophobicity remain practically unchanged.

TL;DR: In this article, the graft copolymer (pAAm-g-GG) of guar gum with acrylamide was prepared and crosslinked with glutaraldehyde to form the hydrogel microspheres by the water-in-oil (w/o) emulsification method.

TL;DR: Pyro/chitosan films exhibited much better pH-sensitive swelling and controlled release properties due to their relatively weak electrostatic interaction, which may be promising for site-specific drug delivery in the stomach.

TL;DR: Transmission electron microscopy studies proved the collagenous nature of this material: high magnifications showed the typical periodic banding-pattern of collagen fibres, and the results of the amino acid analysis differed from most publications, presumably due to impurities that still were present.

TL;DR: The results indicate a use of chitosan as antimicrobial preservative in emulsion formulations for mucosal as well for parenteral applications and in hemolysis studies on human erythrocytes, according to the European Pharmacopoeia.

TL;DR: The determination of chlorhexidine in saliva showed the capacity of these formulations to give a prolonged release of the drug in the buccal cavity and the improvement is particularly high against Candida albicans.

TL;DR: DO-FUdR-SLN can improve the ability of the drug to penetrate through the blood-brain barrier and is a promising drug targeting system for the treatment of central nervous system disorders.

TL;DR: The pharmacopoeial requirements for the preservation of eye drops, the factors affecting ocular tolerance as well as the adverse external ocular effects induced by preservatives are presented.

TL;DR: Performance of score lines can be defined by breaking ease, uniformity of mass of subdivided tablets and loss of mass by the subdivision, and a requirement has been set by the European Pharmacopoeia.

TL;DR: Results indicated that micronized SFL inclusion complex powders dissolved faster in aqueous dissolution media than inclusion complexes formed by conventional techniques due to higher surface areas and stabilized inclusion complexes obtained by ultra-rapid freezing.

TL;DR: Drying process greatly influenced BB release profile due to the destroying of alginate-chitosan film, which resulted in the significant burst of beads and accelerated BB release when 0.3 or 0.5% (w/v) chitOSan was used for coating.

TL;DR: Findings indicated that Gd-nanoCPs had a high affinity to the cells, probably contributing to the long retention of Gd in tumor tissue and leading to the significant suppression of tumor growth in the in vivo studies that were previously reported.

TL;DR: The pectin-HPMC envelope was found to be a promising drug delivery system for those drugs to be delivered to the colon.

TL;DR: Viscoelastic measurements including oscillation stress sweep tests and oscillation frequency sweep tests demonstrated that the existence of a solid particle matrix with a particle size in the nanometer range is a prerequisite to form a semisolid dispersion having the appropriate consistency for topical application.

TL;DR: Results show that an important microparticle backflow occurs in healthy rats, whereas the microspheres remain at the site of administration in C6 glioma-bearing rats.

TL;DR: In this article, a proof-of-principle study was performed with a new colistin dry powder inhalation system in six healthy volunteers and five patients with cystic fibrosis.

TL;DR: A series of diblock copolymers based on methoxypolyethylene glycol-block-poly(caprolactone) (MePEG-b-PCL) was synthesized and evaluated for enhancing the cellular accumulation of a P-glycoprotein (P-gp) substrate into caco-2 cells.

TL;DR: The role of one oligonucleotide, G3139, which is targeted to the coding region of bcl-2 messenger RNA, in inhibiting tumor progression in vitro and in clinical trials, is described.

TL;DR: This study demonstrates that PCA of Raman spectroscopic data provides a sensitive method for the quantitative analysis of polymorphic impurities of drugs in commercial tablets with a quantitation limit of less than 2%.

TL;DR: The principal item is the crossflow injection module, specifically designed for this purpose, which has the benefit of defined and characterized injection streams and permits liposome manufacture regardless of production scale, as scale is determined only by the free disposable vessel volumes.

TL;DR: The results of DSC and XRD indicated that the solid structure of the extrudates corresponded to that of a physical mixture of the components, hence there had been no change in the physical form of the drug induced by extrusion.

TL;DR: The in vitro penetration of retinol into hairless mice skin in this formulation was compared to Retinol formulations without microparticles, which increased significantly by approximately two-fold and had no influence on the chemical stability ofretinol in the hydrogel.

TL;DR: The results demonstrated that SFL is a feasible technique for forming porous microparticles containing insulin and the physicochemical properties of insulin were preserved by the SFL technique.

TL;DR: It is demonstrated that the inclusion of Transcutol CG in sunscreen formulations increases the skin accumulation of the UV absorbers oxybenzone and cinnamate without a concomitant increase in transdermal permeation.

TL;DR: After coating of the pellets with an ethylcellulose film, none of the batches could be filled to an acceptable standard, because electrostatic loading led to a blockage of the filling mechanism.

TL;DR: The use of a second hydrophilic surfactant to adjust the packing properties of the lecithin at the oil-water interface provided an increase in the stability of lipid emulsions, and this may be of importance in the formulation of drug delivery systems.

TL;DR: By multicompaction, bulk density increases which indicates that the porosity of granules decreased during the multiple compaction cycles, however, the ability of MCC to form bondings with neighbouring particles is diminished during various cycles which results in decreasing crushing forces of the subsequently prepared tablets.

TL;DR: Pharmacokinetics of verapamil in a dose of 40 mg and its metabolite norverapamils from the new oral drug formulation in a form of capsule filled with floating pellets was determined.

TL;DR: The use of 4% BSA in the receiver chamber during transport studies can dramatically affect the estimated Caco-2 P(app) and BCS permeability ranking of highly lipophilic NCEs, as in the case of Sch-Y with a log PC of 4.0.