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Showing papers in "European Journal of Pharmaceutics and Biopharmaceutics in 2013"


Journal ArticleDOI
TL;DR: Critical aspects and recent advances in formulation, preparation and characterization of solid dispersions as well as in-depth pharmaceutical solutions to overcome some problems and issues that limit the development and marketability of solid dispersion products are reviewed.

510 citations


Journal ArticleDOI
TL;DR: The current state of development for the LPNs preparation and applications is detailed, from which future research works needed to bring theLPNs closer to its clinical realization are identified.

496 citations


Journal ArticleDOI
TL;DR: Amino acids appear as promising excipients to solve challenges connected with the stability and dissolution of amorphous drugs.

240 citations


Journal ArticleDOI
TL;DR: The results suggest that Caco-2/HT29/Raji B triple co-culture normal oriented cellular model may be reliable to obtain a more physiological, functional, and reproducible in vitro model of the intestinal barrier to study protein absorption, both in solution and when delivered by nanocarriers.

219 citations


Journal ArticleDOI
TL;DR: It was found that hot-melt extrusion of carbamazepine and Soluplus is feasible on a single-screw hot-Melt extruder without the addition of plasticizers, and thermodynamic models obtained are in agreement with the findings of the HME processing, encouraging therefore their further application in theHME process development.

181 citations


Journal ArticleDOI
TL;DR: Study indicates protective role of curcumin against cerebral ischemic insult; provided it is packaged suitably for improved brain delivery, as well as restoring SOD, GSH, catalase, and mitochondrial complex enzyme levels equivalent to sham control values.

169 citations


Journal ArticleDOI
TL;DR: The potential of amino acids as small molecular weight excipients in co-amorphous formulations to stabilize the amorphous form of a poorly water-soluble drug through strong and specific molecular interactions with the drug is shown.

148 citations


Journal ArticleDOI
TL;DR: In this review, fundamentals of ice nucleation in the field of freeze-drying are presented, the impact of controlledIce nucleation on product qualities is discussed, and methods to achieve controlled Ice nucleation are presented.

147 citations


Journal ArticleDOI
TL;DR: A classification system is proposed classifying the nanoparticles in four classes (I to IV) from low/no risk to high risk, based on the nanoparticle size and size-related differences in interaction with human cells, and on biodegradability/non-biodegradable in the body.

141 citations


Journal ArticleDOI
TL;DR: The dogma of "never lyophilize above the glass transition temperature" is argued, and recent insights into novel stabilization concepts are provided.

140 citations



Journal ArticleDOI
TL;DR: The focus of this review is injectable, targeted nanoparticle drug delivery carriers highlighting the diversity of nanoparticle materials and structures as well as highlighting current therapeutics and targeting moieties.

Journal ArticleDOI
TL;DR: An overview of the process analytical technologies used during fluid bed granulation to monitor and control the process is given and analysis and modeling tools enabling the extraction of the relevant information from the complex data collected during granulation and the control of theprocess are highlighted.

Journal ArticleDOI
TL;DR: The results demonstrate the specificity of C12GEM targeting toward CD44-overexpressing pancreatic adenocarcinoma cell line using HA as a ligand and the cytotoxicity of the different preparations was evaluated.

Journal ArticleDOI
TL;DR: The results suggest that with suitable particle size, good dispersibility and solid-state properties, selected trehalose/leucine combinations appear to have good potential for development into a universal carrier platform for pulmonary delivery of potent biomacromolecules.

Journal ArticleDOI
TL;DR: GC-PLGA NPs could be a promising carrier adjuvant for the nasal vaccine delivery for inducing a potent immune response at mucosal surface(s) and systemic circulation.

Journal ArticleDOI
TL;DR: It is demonstrated that the EIF encapsulated core-shell nanofibers might serve as a promising tissue engineered graft for skin regeneration.

Journal ArticleDOI
TL;DR: Modelling and supporting measurement tools for the high shear wet granulation (HSWG) process are reviewed, and the twin-screw granulator as a device for continuous HSWG is focused on and a set of open research questions are identified.

Journal ArticleDOI
TL;DR: In vivo biodistribution studies of intravenous camptothecin-loaded SLN performed in rats proved the positive role of SLN on the brain targeting since significant higher brain accumulation of campthecin was observed, compared to non-encapsulated drug.

Journal ArticleDOI
TL;DR: Several mucoadhesion test methods are reviewed concerning the applicability for various polymers, different drug dosage forms and comparability of experimental set-ups.

Journal ArticleDOI
TL;DR: The data suggest that some limited penetration of coated and uncoated ZnO-NP may occur into viable stratum granulosum epidermis adjacent to furrows, but that the extent is not sufficient to affect the redox state of those viable cells.

Journal ArticleDOI
TL;DR: The newly developed physiologically based pharmacokinetic (PBPK) in silico model predicted that the bioavailability of itraconazole is likely to be increased after oral administration of ternary complex formulations, especially when it raconazoles is formulated as a ternARY complex comprising HP-β-CD or HBen-β -CD and Soluplus®.

Journal ArticleDOI
TL;DR: The main goal of the present study was to evaluate applicability of the different model substrates, namely orodispersible films (ODFs), porous copy paper sheets, and water impermeable transparency films (TFs) in preparation of the inkjet-printed drug-delivery systems.

Journal ArticleDOI
TL;DR: PEG-functionalized PLGA microparticles were qualified as an innovative drug delivery system that may serve as a selective treatment strategy to inflamed mucosal areas in IBD with the potential to improve therapeutic efficacy and to reduce adverse events.

Journal ArticleDOI
TL;DR: Even though the parameters were not optimized for spray drying all phages, it was demonstrated that spray drying phages with this industrial relevant and scalable set up was possible and the resulting powders had desirable size ranges for pulmonary delivery of phage with dry powder inhalers (DPIs).

Journal ArticleDOI
TL;DR: The results of this study showed increased dissolution and bioavailability of the solid dispersion of the Soluplus-based carrier loading ITZ prepared by HME compared with the ITZ nanosuspension prepared by wet milling.

Journal ArticleDOI
TL;DR: Several in-process techniques for particle size determination are reviewed and compared to well-known and widespread off-line reference methods and a theoretical explanation of the working mechanism behind each sizing technique is presented.

Journal ArticleDOI
TL;DR: An advanced buccal in vitro model for studying transport of nanoparticles, taking the mucus layer into account was developed and revealed that porcine mucin is most similar to human natural mucin in chemical structure and morphology.

Journal ArticleDOI
TL;DR: This work has shown that an excipient-free triple antibiotic DPI formulation could be used as a significant enhanced treatment for TB.

Journal ArticleDOI
TL;DR: Enhanced performance of critical quality attributes (CQAs) under the hybrid control scheme compared to only PID or MPC control schemes is demonstrated, illustrating the potential of a hybrid control schemes in improving pharmaceutical manufacturing operations.