Showing papers in "European Journal of Pharmaceutics and Biopharmaceutics in 2018"

TL;DR: An overview of the most prominent antibacterial agents incorporated in wound Dressings along with their mode of action is provided and the recent advances in the therapeutic approaches used in the clinic and some future perspectives regarding antibacterial wound dressings are discussed.

TL;DR: The importance of obtaining a detailed knowledge of the structure of the lipid nanoparticles is highlighted, which is useful for the rational design of this type of nanocarriers and propose solutions to the challenges involved in their formulation.

TL;DR: The present review article attempts to highlight the different experimental and computational approaches pursued so far to attain and enhance the direct delivery of therapeutic agents to the brain and shed some light on the underlying mechanisms involved in the pathogenesis and treatment of neurological disorders.

TL;DR: A consensus on the role of the proton sponge hypothesis in endosomal escape of polyplexes is launched due to many contradictory reports that have been published on this subject.

TL;DR: Skin microporation achieved by poly (vinyl alcohol) microneedles was found to enhance transdermal delivery of doxorubicin in vitro and affect the drug release profile as well as its permeation into and across human skin.

TL;DR: This combined nano‐delivery system maximized synergistic cytotoxicity of RAP and WOG in terms of tumor inhibition in MCF‐7 breast cancer cells and Ehrlich ascites tumor animal model as a result of enhanced active targeting.

TL;DR: It is demonstrated that the NaAlg/PVPI films are biocompatible and possess healing properties that accelerate the wound closure, and are able to reduce the inflammatory response both in human foreskin fibroblasts after lipopolysaccharide stimulus and in rodents after wound induction.

TL;DR: The potential of combining hydrophilic and hydrophobic polymers to design the desired wound dressings via the electrospinning process is demonstrated.

TL;DR: This overview identifies the most commonly incorporated excipients employed as buffering agents, stabilisers/bulking agents, surfactants, preservatives and tonicifiers, including their concentration ranges of use in both liquid and lyophilised formulation approaches.

TL;DR: Ex‐vivo permeation studies showed that the liposomal hydrogel formulation enabled a sustained and controlled delivery of opiorphin over more than 5 h, and highlighted the role of theliposomal carrier in enhancing up to 6 times permeability coefficient and permeation rate of the peptide through the lipophilic nasal mucosa compared to a free peptide‐loaded gel.

TL;DR: Considering the ability for drug entrapment, easy preparation and controlled release, this class of material allows potential applications in drug delivery systems.

TL;DR: 3D printed forms were as proportionately effective as their comparative solution form in doubling plasma exposure following a doubling of warfarin dose and to accurately titrate coumarin dose response to an individual patient.

TL;DR: This work shows that even under standardized clinical conditions, residual gastric volumes and water emptying are highly variable, and Interestingly, interindividual and intraindividual variabilities of both parameters were comparable, suggesting that the variability within the studies was mainly resulting from intrainingdividual day‐to‐day variations.

TL;DR: Solid lipid nanoparticles decorated with angiopep‐2 can be an excellent option as targeted drug delivery system for antiglioma therapy, indicated.

TL;DR: The obtained results are promising for a further development of lactose oleate as an intestinal absorption enhancer and/or an alternative biodegradable preservative for pharmaceutical and food applications.

TL;DR: Microneedles are an effective method with high bioavailability for local dermal delivery of insoluble drugs and improved the safety of CyA delivery because the slow systemic absorption and local treatment enabled CyA to remain in the skin for a longer time.

TL;DR: Lyophilisation was utilised to increase the loading of RALA/pDNA nanoparticles within dissolvable PVA microneedles and delivery was significantly enhanced in vivo into an appropriate range for DNA vaccination, and proved superior to standard intramuscular injection in a preclinical model of cervical cancer.

TL;DR: NPs functionalization with a transferrin receptor‐binding peptide, envisaging BBB targeting, proved to be effective concerning nuclear magnetic resonance analysis, and functionalized nanosystems were able to interact more efficiently with BBB cells, and permeability of EFV associated with NPs through a BBB in vitro model was around 1‐fold higher than the free drug.

TL;DR: Several critical formulation parameters are identified for the further development of NP‐loaded dissolving MNs loaded with PLGA nanoparticles co‐encapsulating ovalbumin (OVA) and poly(I:C) for intradermal immunisation.

TL;DR: Overall, silicone hydrogel CLs functionalized with bioinspired chemical groups represent a first attempt to design contact lenses adapted to the needs of diabetic eyes, acting as controlled release platforms of epalrestat, promoting drug accumulation and diffusion through cornea.

TL;DR: PEGDA‐pNIPAAM‐HA‐INF hydrogels demonstrated sustained release of INF in a two‐compartment in vitro outflow model of the human eye called the PK‐Eye and suggest that PEGDA'S has potential for the continued development of formulations to prolong the intraocular release of proteins.

TL;DR: A dramatic increase in the levels of resveratrol reaching the CSF was attained by the administration of an aqueous suspension of LMs‐Res‐Ch‐plus with a Cmax after 60 min of 9.7 ± 1.9, demonstrating a direct and specific nose to brain delivery.

TL;DR: The evolution, present status, and future trends on the applicability of biorelevant in vitro dissolution testing and in silico modeling for predicting oral absorption and pharmacokinetics of poorly soluble weakly basic drugs are discussed.

TL;DR: Both CS‐OA and &agr;Tph NE stimulated cell proliferation on keratinocytes and fibroblast cell cultures, and in ex vivo skin biopsies, suggesting the suitability of CS‐oa and of the antioxidant agent for topical application in wound healing.

TL;DR: The potential of baicalin‐loaded nanohydrogels in skin wound healing was demonstrated in vivo in mice by complete skin restoration and inhibition of specific inflammatory markers (i.e., myeloperoxidase, tumor necrosis factor‐&agr;, and oedema).

TL;DR: Investigation of the potential use of oxcarbazepine (OXC) to enhance brain targeting efficiency after intranasal (IN) administration confirmed the possibility of developing a novel non‐invasive nose to brain delivery system of OXC for the treatment of epilepsy.

TL;DR: Results suggest that nanoparticles might be a promising pH‐sensitive drug delivery system for applications in anticancer treatment and Haemocompatibility test results suggest that the nanoparticles exhibit suitable blood compatibility for biological applications.

TL;DR: The results suggest that the screening of complement activation by polymer‐modified products in tandem with anti‐polymer antibody production should be a prerequisite in the development of polymers that might enhance the therapeutic efficacy of nanocarriers.

TL;DR: It is demonstrated that spray dried Myoviridae and Podoviraceae phage in a simple formulation of leucine and trehalose can be successfully stored for one year at 4 °C and 20 °C with vacuum packaging.

TL;DR: Dox‐SeLPs significantly improved the pharmacokinetic property and enhanced the antitumor efficacy of Dox in tumor‐bearing mice and exhibit good sustained release for Dox and have synergic anticancer effect with Dox, which may be promising as drug delivery vehicle.