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Showing papers in "European Journal of Pharmacology in 1968"


Journal ArticleDOI
TL;DR: It is suggested that intracerebral administration of 6-hydroxy-dopamine may be used as a tool for anatomical and functional studies on central monoamine neurons.

1,542 citations


Journal ArticleDOI
TL;DR: Local application of colchicine to adrenergic ganglia and axons seems to interrupt the fast proximo-distal transport of amine storage granules, due to destruction of neurotubules, which possibly take part in granular transport.

440 citations


Journal ArticleDOI
TL;DR: A good correlation has been found between the intensity of behavioural excitation and the decrease of 5-HT and 5-HIAA levels in the forebrain in rats.

288 citations


Journal ArticleDOI
TL;DR: In this article, 6-hydroxydopamine (6-OH-DA) has been shown to deplete adrenergic nerves very rapidly of endogenous noradrenaline (NA).

284 citations


Journal ArticleDOI
TL;DR: The formation of 3H-5HT from3H-TRY was significantly increased in the brain of stressed animals and the utilization of this labelled amine synthesized endogenously was markedly accelerated during the stress situation.

200 citations


Journal ArticleDOI
TL;DR: Evidence was obtained that amphetamine probably releases mainly extragranular amines from central dopamine and noradrenaline neurons, and the results with tryptamine indicate that this drug in relatively high doses may have a presynaptic action on the 5-hydroxytryptamine neurons probably by increasing the release of 5-HydroxyTryptamine over the cell membrane.

162 citations


Journal ArticleDOI
TL;DR: All three monoamines applied extracellularly to spinal neurones caused an increase in membrane polarization, a decrease in amplitude of EPSPs and IPSPs and blocked the synaptic or antidromic invasion of some neurones, compatible with those of an inhibitory transmitter.

151 citations


Journal ArticleDOI
TL;DR: In this article, the influence of 2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride (ST 155) on spontaneous discharges of sympathetic nerve and on evoked discharges elicited by chemostimulant drugs or electrical stimulation of sympathetic structures of the brain stem was investigated.

149 citations


Journal ArticleDOI
TL;DR: The pharmacokinetics of intravenous infusion is studied for models assuming more than one body compartment, and the rate of which decreases exponentially to the proper steady-state rate is studied.

149 citations


Journal ArticleDOI
TL;DR: It was found that, among the various psychotropic drugs studied, only chlordiazepoxide, diazepam, meprobamate and phenobarbital increased the number of punished crossings whereas imorphine decreased it.

128 citations


Journal ArticleDOI
TL;DR: There is a significant correlation between the decrease of cerebral serotonin, the decreases of slow wave sleep and the rate of occurrence of paradoxical sleep in the rat.

Journal ArticleDOI
TL;DR: The results are taken as evidence that desipramine selectively acts on noradrenaline neurons in the brain, whereas chlorpromazine and haloperidol primarily affect dopamine neurons where synthesis and turnover of the transmitter is increased.

Journal ArticleDOI
TL;DR: It is concluded that although ST 155 induced a certain degree of α-adrenergic blockade, this effect is not sufficient to account for the hypotensive action of the drug.

Journal ArticleDOI
TL;DR: It is concluded that the hypertensive effect of Catapres is due to sympathomimetic constriction of peripheral vasculature, indicating that hypotension and bradycardia are centrally mediated.

Journal ArticleDOI
TL;DR: The results of the present studies suggest that exogenous gastrin acts and that the common mechanism for all other agents which cause an activation of gastric histidine decarboxylase may be the release of endogenous gastrin.

Journal ArticleDOI
TL;DR: The experiments support the hypothesis that amphetamine stimulates cortical ACh output by acting on catecholamine nerve terminals which make synaptic connection with cholinergic neurons in the rostral part of the brain.

Journal ArticleDOI
TL;DR: Experiments showed that the slow spontaneous recovery after DFP poisoning was not caused by cholinesterase reactivation or synthesis, and the possible mechanism is discussed.

Journal ArticleDOI
TL;DR: The findings support the hypothesis that carrageenin acts through a proteolytic process with formation of kinin-like mediator(s) in the rat's paw.

Journal ArticleDOI
TL;DR: Diazepam showed an antimetrazol activity which was longer-lasting in mice than in rats, and the three main metabolites of diazepam, namely N-methyloxazepam, N-desmethyldiazepam and oxazepAM showed strong anticonvulsant activity in mice.

Journal ArticleDOI
TL;DR: The weak β-blocker (+)-propranolol showed almost the identical local anesthetic as the more potent racemate, suggesting a minimum of complementarity between this drug and the receptor system mediating local anesthesia.

Journal ArticleDOI
TL;DR: High doses of 2-(2, 6-dichlorphenylamino)-2-imidazoline hydrochloride (ST 155) were found to induce biting attacks in mice, and neuroleptic agents were the most effective in antagonizing such aggressive behavior.

Journal ArticleDOI
G.A. Charbon1
TL;DR: Parathyroid hormone (PTH) augmented in dogs the hepatic and renal blood flow within 1 minute of its injection and caused a sustained increase of the coeliac flow.

Journal ArticleDOI
TL;DR: It is concluded that cholinesterase inhibitors cause the thermoregulation in the rat to collapse for about 6 hours, followed by a recovery in 12 to 20 hours.

Journal ArticleDOI
TL;DR: Investigation of the mechanism of the interaction between morphine and cocaine and some other local anaesthetics and amphetamine and imipramine were tested in combination with morphine found that ability to potentiate morphine was not related to local anaesthetic activity.

Journal ArticleDOI
TL;DR: The ability of p -chloro-mercuribenzoate and of dithioerythritol to inhibit the cholinergic receptor favors the view that a protein is a part of the receptor structure.

Journal ArticleDOI
TL;DR: St 155 differs from other clinically useful antihypertensives in its mode of action, and it is suggested that the depressor action of St 155 may be due to a central reduction of sympathetic outflow to the heart and blood vessels.

Journal ArticleDOI
TL;DR: Results indicate that NA tuniover is not affected immediately after the operation, but is accelerated six days after adrenalectomy, and changes in central turnover of norepinephrine are studied.

Journal ArticleDOI
TL;DR: Male rats given a combination of the peripheral DOPA decarboxylase inhibitor Ro 4-4602 and DOPA, showed motor excitation as well as a peculiar and bizarre pattern of social behaviour, and the possible role of brain dopamine in this social behaviour is discussed.

Journal ArticleDOI
TL;DR: Determination of serotonin and noradrenalin brain levels shows that ovulation is only affected by increased brain serotonin, and it is concluded that this amine has a specific inhibitory effect on the release of pituitary ovulation hormone.

Journal ArticleDOI
TL;DR: Data are consistent with the hypothesis that ST-155 produces a central hypotensive effect mediated by a reduction in sympathetic tone and intravenous injection to intact dogs was found to reduce peripheral vascular resistance.