Showing papers in "European Journal of Pharmacology in 1973"

TL;DR: Findings indicate that MHPG-sulfate levels are dependent upon the integrity of NE neurons and that the level of rate of formation of MH PG-solfate in the brain can be a reflection of the physiological activity of these neurons.

TL;DR: Upon repeated administration of 7–21 daily doses of loxapine and haloperidol, the rats develop a very marked and fairly long-lasting tolerance toward the above actions of the drugs.

TL;DR: The results demonstrate a clearcut dissociation between the sites of biosynthesis and metabolism in the kidney and the function of the cortical PGDH might be either to inactive prostaglandins formed in medulla or to protect medullary PG receptors from high levels of circulating prostag landins.

TL;DR: Stereotypy was reduced, both during the acute and chronic stages following ablation of the nucleus amygdaloideus centralis, but was not modified by lesion of the stria terminalis, and the possibility that apomorphine may modify pre- as well as post-synaptic mechanisms is considered.

TL;DR: The gastric ulcers produced by indomethacin and oxyphenbutazone were significantly reduced by pretreatment with phenoxy-benzamine, phentolamine and by prior bilateral adrenalectomy and spinal cord transection while imipramine pre-treatment potentiated their incidence.

TL;DR: It is suggested that PGE2 can modify but not stop the release of DA and NA from central CA nerve terminals and indicate that prostaglandins might act as modulators of central CA neurotransmission.

TL;DR: The results indicate either that presynaptic events are important in the mediation of apomorphine-stereotyped behaviour, or that the currently accepted hypotheses on the mode of action of the indole and benzoquinolizine derivatives may require revision to include an effect upon post-synaptic events.

TL;DR: The results suggest that the rigidity was morphine specific and was due to a functional dopamine deficiency in the striata, and could be explained by ‘diversion’ of newly synthetized dopamine from storage sites to sites of catabolism resulting in a lack of dopamine at striatal receptor sites which might lead to a subsequent compensatory increase of dopamine utilization.

TL;DR: The potency of various neuroleptic drugs in increasing the content of endogenous 3-methoxy-4-hydroxyphenyl-ethylene glycol in rat brain decreased and the activation of noradrenergic neurons by neuroleptics does not seem to parallel that of dopaminergic neurons.

TL;DR: Evidence presented in this study suggests that the central actions of quipazine may be due to activation of serotonergic processes, which is similar to those induced by the serotonin precursor.

TL;DR: Guinea-pig hearts, perfused withTyrode containing 8 mM taurine, show a less marked decrease of contractile force when washed out with calcium-free Tyrode than control hearts, and the hypothesis is advanced that taurines increases the affinity of some cell structure for calcium.

TL;DR: It is indicated that mescaline has differing effects on raphe neurons depending on whether it is given systemically or microiontophoretically, and that LSD given systemic or microionscriptically has similar effects onRaphe neurons.

TL;DR: It has been found that it is possible with this schedule of injection of 6-OH-DA to produce animals which have significantly reduced levels of brain NE (70% depletion) without decreasing NE in tissues outside the CNS.

TL;DR: The results and the estimation of the conversion index of tyrosine into DA (3H-DA/tyrosine specific activity) indicated that morphine stimulated DA synthesis, and the increased endogenous levels of DA seen after morphine are related to the increased synthesis of the transmitter.

TL;DR: In mice, yohimbine antagonized very effectively the prolongation of chloral-induced sleep by clonidine; 883F was effective at high dosage but the other α-adrenoceptor blocking agents were ineffective; these results support the hypothesis that sedation induced byClonidine is mediated by the activation of α- adrenoceptors different from the peripheral adrenoceptor.

TL;DR: The results indicate that the structural requirements for the cataleptogenic and HVA-increasing properties of the narcotic analgesics bear some relation to those required for the pain-relieving properties of these drugs.

TL;DR: It is concluded that the action of DDT and allethrin in the lateral-line organ is not primarily on the hair cells, but on the impulse-generating process in the afferent nerve terminal, probably by an effect on the sodium conductance of the membrane.

TL;DR: The d- methamphetamine drug state acquired all the properties of a discriminative stimulus by producing interoceptive cues in rats trained to choose between the side compartments of a 3-chambered shock-escape apparatus according to whether they were injected with d-amphetamine or 0.9% saline.

TL;DR: Sets of theoretical concentration-effect curves predicted by the new model were compared with experimental results obtained from functional antagonism and functional synergism studies and the agreement between the characters of the sets of theoretical and experimental curves was satisfactory.

TL;DR: The results indicate that the level of norepinephrine in the cerebral cortex is in part dependent on the nerve impulse flow through the adrenergic fibres and are in favor of the concept of a multiple storage form for NE in the central nerve terminals.

TL;DR: In this paper, it was concluded that α-methyldopa lowers blood pressure by a central mechanism involving the production of α-methylnoradrenaline which may act as a false neurohumoral transmitter substance.

TL;DR: It is concluded that the antagonizing effect of central monoamine depletion on the anti-nociceptive effect of morphine, pethidine and aminophenazone in the rat is due to a change in the basal motor activity on which the spinal nocICEptive reflex is elicited.

TL;DR: In this article, a new model of functional interaction introduced in the literature was verified in a number of experimental situations and the theoretical predictions based on the model were shown to correspond with the results obtained with different types of drugs and in different test systems.

TL;DR: It is concluded that ketamine inhibits the membrane amine pump in the terminals of postganglionic adrenergic neurones in a cocaine-like manner.

TL;DR: The anorexigenic effect of fenfluramine in rats was inhibited by a preceding intraventricular (i.vent.) injection of 5, 6-dihydroxytryptamine (5,6-DHT), suggesting that, in addition to serotonin, other indoleamines may be involved in the pharmacological actions of fyodorine.

TL;DR: The results further support the hypothesis of a direct interaction of fenfluramine with the serotonergic system in the brain.

TL;DR: It is concluded that even if an inflammatory agent is able to release substances affecting permeability such as histamine, serotonin or bradykinin in diabetic animals, their final effect upon vessels is reduced, thus suggesting a local influence of insulin in the control of vascular permeability and therefore in inflammation.

TL;DR: A pressor response was obtained in the rat following both intravenous and intraventricular administration of physostigmine, mediated via central muscarinic mechanisms.

TL;DR: It is concluded that angiotensin does not constitute the final mediator in the brain of thirst evoked by systemic β-adrenergic activation, and the close similarity of effects upon eating behavior obtained with the peripheral and central route of administration are interpreted as evidence for the existence of β- adrenergically coded satiety circuits.

TL;DR: Apomorphine lowered body temperature in rats and mice and raised the brain 5-HIAA level and it was noted that apomorphine directly stimulated central dopamine receptors which indirectly increased 5-HT turnover, this latter action leading to hypothermia.