Showing papers in "European Journal of Pharmacology in 1974"

TL;DR: A simple superfusion technique for studying the release of neurotransmitters from preloaded synaptosomes that has the following advantages: prevention of re-uptake, great flexibility and reliability, and continuous determination of release from parallel samples.

TL;DR: Findings suggest that morphine may exert at least part of this analgesic action through decreasing locus coeruleus impulse flow, however, the mechanism by which morphine decreases noradrenergic neuronal activity remains to be elucidated.

TL;DR: In this article, a double blind procedure was carried out to study possible interaction between cannabidiol (CBD) and Δ9-tetrahydrocannabinol (Δ9-THC) in human beings.

TL;DR: The capability of the rating scale to assess antagonism of d-amphetamine by pimozide suggested that this scale may be a useful quantitative measure of neuroleptic activity of drugs.

TL;DR: Plasma renin activity was measured in rabbits before and after infusion of the prostaglandin precursor, arachidonic acid (C20:4) and of the prostate-rectifying drug, indomethacin, and non-hypotensive doses of C 20:4 increased PRA.

TL;DR: The results indicate that TMB-8 may produce its inhibitory effects in smooth muscle by interfering with the availability of Ca2+ for muscle contraction by blocking the Ca1+ release from intracellular bound stores.

TL;DR: It is concluded that in mice morphine produces locomotor hyperactivity by releasing DA from the presynaptic terminals in the striatum, thus increasing the dopaminergic activity in this structure.

TL;DR: High doses of piperoxane and yohimbine did not block or reduce clonidine-induced increases in flexor reflex activity, which is dependent on noradrenaline (NA) receptor activity, and Adrenaline neurons may, thus, be involved in vasomotor and respiratory control.

TL;DR: In a 59°C hot plate test, it is possible to quantify the narcotic antagonist activities of naloxone, nalorphine and pentazocine.

TL;DR: Evidence has been obtained that there exist large numbers of previously unknown systems of dopamine nerve terminals in the limbic cortex, e.g. in the gyrus cinguli, the entorhinal cortex and the amygdaloid cortex.

TL;DR: The demonstrated relationship between dopamine and 5-hydroxytryptamine (possibly within the striatum) in the mediation of behavioural states indicative of antiparkinson activity may be relevant to the disease state.

TL;DR: Injections of catecholamines into the splenic artery constricted the cod spleen when perfused in situ at constant pressure, indicating that both adrenergic and cholinergic neurones are present, although in different fish the adrenergic/cholinergic ratio varied.

TL;DR: Muscarinic mechanism appear to be involved in the haemodynamic effects of analgesic agents, and a reduction in sympathetic tone contributes to the hypothensive effect in intact and midpontine dogs.

TL;DR: In this article, the concentration-dependent binding of (+)-benzetimide-H3 and (−)-benzinetimides-H 3 to a fraction from bovine tracheal smooth muscle was studied by equilibrium dialysis, and the results of competition experiments with cholinergic and non-cholinergic compounds provided evidence, that the high affinity binding sites for (+-benzetoimide and atropine are identical with the muscarinic receptor.

TL;DR: The brain studies demonstrate a differential involvement of the dopamine-containing areas of the mesolimbic and extrapyramidal brain regions, and the associated dopaminergic neurones which ascend from the mesencephalon, with the stereotyped behaviour patterns induced by both D- and L-amphetamine.

TL;DR: Drugs which interfere with either dopamine, serotonin, or noradrenaline transmission in the CNS have been given to oestrogen- and oestrogens + progesterone-treated female rats and observations made on their sexual behaviour suggest specific roles for these amines in controlling sexual receptivity.

TL;DR: Daily administration of cannabis extract produced a complete arrest of spermatogenesis in mice and regression of Leydig cell tissue and of accessory sex glands was conspicuous.

TL;DR: It is thought that clozapine stimulates the synthesis of striatal dopamine much more strongly than its disappearance, and that it does not primarily block dopamine receptors as typical neuroleptics are thought to do.

TL;DR: High dose of clonidine i.v. enhanced single aortic baroreceptor fibre discharge at a given MAP in anaesthetized animals, but there was no effect at low dose; at high dose these effects are reinforced by peripheralbaroreceptor resetting.

TL;DR: The results suggest an inhibitory role of an α-adrenoceptor in the area of the nucleus tractus solitarii in the central control of blood pressure in anesthetized rats.

TL;DR: Evidence is provided for a role of prostaglandin E2 as an intrarenal hormone regulating the inner cortical and medullary circulation of blood flow in the rabbit kidney.

TL;DR: It is concluded that the hypertensive response to physostigmine in the rat involves the active participation of brain ACh.

TL;DR: It is shown that amphetamine regained its anorexic potency in lesioned animals, while the enhanced potency of fenfluramine remained after operation, consistent with the belief that these two anorexia agents operate through quite separate sites and mechanisms of action.

TL;DR: The results indicate a differential involvement of mesolimbic areas with the behavioural effects of catalepsy and stereotypy antagonism which are used as experimental indicators of antipsychotic activity.

TL;DR: The jumping response was determined to be time dependent and a function of both morphine and naloxone dosage and it is suggested that jumping behavior in mice may result from a sensitization or unmasking action by morphine to a stimulatory effect of n aloxone or from an unantagonized stimulatory action of morphine.

TL;DR: It has been argued that methysergide may owe its therapeutic effectiveness to selective vasoconstriction of carotid vasculature and not to its peripheral antiserotonin properties on the above vessels.

TL;DR: It was concluded that 5-hydroxytryptamine is involved in the anorexigenic effect of high doses of fenfluramine, that catecholamines (principally dopamine) are important in the action of high (and perhaps intermediate) dose levels of amphetamine, and that theAnorexia which follows low doses offen fluramine and amphetamine occurs via mechanisms not involving 5-Hydroxyt Kryptamine, norepinephrine or dopamine

TL;DR: The results indicate that central cardiovascular effects of clonidine are independent of noradrenaline release from central nerve endings, and this effect was antagonized by phentolamine 5 mg/kg i.v.

TL;DR: Neither chlopromazine nor haloperidol affected TH activity in the striatum; however, when either of these neuroleptic drugs was administered concurrently with methamphetamine, the depression of striatal enzyme activity produced by methamphetamine was prevented.

TL;DR: A number of β-adrenoceptor blocking agents were tested for isoprenaline antogonism on rat adipose cells and the pA 2 values were compared to pA 1 values determined previously on guinea-pig atrial and tracheal preparations.