Showing papers in "European Journal of Pharmacology in 1978"

TL;DR: Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.

TL;DR: The results suggest that SK & F 38393 may selectively stimulate supersensitive central dopamine receptors in vivo or may activate only a certain subclass of dopamine receptors including the receptor in the renal vasculature and the adenylate cyclase coupled postsynaptic receptors in the caudate.

TL;DR: Important differences exist between strains in both the amount of immobility observed and the effects of imipramine, and strain differences should be taken into account in attempts to replicate results from one laboratory to another.

TL;DR: It was suggested that carrageenin hyperalgesia has a peripheral and a central component and that the cyclo-oxygenase inhibitors used may exert an antialgesic effect by preventing the hyperalGESia induced by a peripheraland/or central release of prostaglandins.

TL;DR: Naloxone displaced 3H-GABA from receptor sites in rate forebrain and cerebellum, with similar low potency, and Diazepam, which protects mice against convulsions elicited by bicuculline, but not by strychnine, also protected mice against nalox one.

TL;DR: The results are interpreted to indicate that DTγE or a closely related peptide is an endogenous neuroleptic and may be that a reduced availability as a result of an inborn error in the generation ofDTγE is an etiological factor in psychopathological states for which Neuroleptic drugs are beneficial.

TL;DR: The results suggest that in vitro 3H-diazepam binding represents the physiologically relevant binding to hitherto unknown receptors in the CNS, and nonbenzodiazepines, representing 22 distinct pharmacological classes as well as 14 presumed neurotransmitters inThe CNS, were much weaker as 3Diazepam displacers.

TL;DR: Although the BZs did not alter the spontaneous firing rate of the DR, both the systemic and iontophoretic administration of these drugs were found to potentiate the inhibitory response produced by GABA, suggesting that this potentiation is mediated postsynaptically.

TL;DR: Baclofen has been clearly shown to exert an antinociceptive effect at the spinal level, in addition to its previously suggested supraspinal action, and may be compared with a similar dual site of action of morphine.

TL;DR: The results provide further support for the purinergic nerve hypothesis by showing that no significant release of ATP was detected during comparable responses elicited by direct muscle stimulation.

TL;DR: Racemic and l-baclofen partly antagonized electro-ionotrophoretically and it was conlcuded that the biologica activity of bacl ofen resides with the l-enantiomer.

TL;DR: Evidence was sought for the role of ATP as a possible co-transmitter following neural stimulation of the smooth muscle of the in vitro guinea-pig vas deferens and it seems possible that in this tissue ATP, in addition to its other functions, may serve as a co- Transmitter with norepinephrine.

TL;DR: Results obtained with naloxone given intracisternally indicate that the pressor and depressor actions as well as the bradycardia are mediated through opiate receptors and indicate that opioid peptides may be involved in central cardiovascular control.

TL;DR: Relative pharmacological potencies of the optical isomers of ketamine have been estimated in ICR mice and at equianalgesic doses (+)-ketamine caused less stimulation of locomotor activity than the (-)-isomer.

TL;DR: Intrahippocampal injection of kainate may be a useful rodent model for temporal lobe seizure disorders and the synaptosomal high affinity uptake process for [3H]choline and [ 3H]norepinephrine are significantly reduced at 10 days after injection.

TL;DR: The results fit well with the hypothesis that NA restrains, via alpha-receptors, the ACh secretion from the nerve endings and indirectly support the view that the amine reduces the firing rate of the corticopetal cholinergic neurones.

TL;DR: Differences are discussed in terms of differential abilities to induce extrapyramidal disturbances and the mouse climbing model is forwarded as a test with potential to detect antipsychotic agents of different activity spectra.

TL;DR: The results support the hypothesis that at least some of the central stimulant effects of the methylxanthines could be related to blockade of a purinergic inhibitory tone on noradrenergic synaptic output.

TL;DR: The results support the hypothesis that the rotating rodent requires two functional dopamine components: striatal dopamine imbalance causing a postural asymmetry and stimulation of mesolimbic dopamine systems providing a locomotor component.

TL;DR: The contralateral turning and the stereotypes induced by the acute, intranigral administration of muscimol were very similar to the chronic effects elicited by intranIGral kainic acid (k.a.) observed from 24 h to several days after treatment.

TL;DR: In pharmacologically active doses sodium pentobarbital, strychnine, picrotoxin and bicuculline fail to influence [3H] flunitrazepam binding in vivo, and benzodiazepine potencies correspond to pharmacological potencies and parallel relative affinites for binding sites in isolated brain membranes.

TL;DR: It is suggested that angiotensin II induced a positive chronotropic and slight positive inotropic effect via angiotENSin II receptors in the dog heart.

TL;DR: The results indicate that metoclopramide is a potent, surmountable and selective antagonist of tryptamine receptors on rabbit cardiac sympathetic nerves.