Showing papers in "European Journal of Pharmacology in 1982"

TL;DR: Following desensitisation of the excitatory P2-purinoceptors in the guinea-pig urinary bladder, theexcitatory responses to non-adrenergic, non-cholinergic nerve stimulation were abolished, while those to acetylcholine and histamine were little affected, consistent with the purinergic nerve hypothesis.

TL;DR: It is suggested that sex and estrous cycle dependent differences in rotational behavior may be due to the direct or indirect modulation of mesostriatal dopamine activity by gonadal steroid hormone.

TL;DR: It is proposed that an aspartergic component may contribute to the development of convulsions after 3MPA, TSC, DMCM and picrotoxin.

TL;DR: The results further support the concepts that neurogenic vasodilatation and plasma extravasation are mediated by SP, and that somatostatin and opiates inhibit the release of SP from peripheral sensory nerve endings.

TL;DR: The potency of xanthine derivatives as adenosine antagonists was studied in fat cells and hippocampal slices (A2-receptors) and on L-[3H]phenylisopropyladenosine (PIA) binding in membranes from rat cortex.

TL;DR: Naltrexone methylbromide effectively antagonizes the acute gut stimulating effect, but not the chronic behavioral effect of morphine administration in dogs, and does not cross the blood-brain barrier in rats but may in mice.

TL;DR: It is found that a single injection of AMPH produced a long-lasting (1 month) enhancement in AMPH-induced rota-tional behavior, and in AM PH-stimulated DA release from striatal tissue in vitro (Robinson et al., 1982), which hypothesized that the behav-ioral sensitization produced by repeated AMPH injections would also be accompanied by an enhancement of striatal DA release.

TL;DR: The analgesic action of β-endorphin, as observed in the hot plate test with rats, was effectively suppressed by intracerebroventricular (i.c.v.) injection of caerulein and cholecystokinin octapeptide (CCK-8).

TL;DR: There were, however, significant differences in the affinities of certain alpha-antagonists between cerebral and platelet preparations, even though these agents generated displacement curves with slopes close to unity in both tissues.

TL;DR: It is suggested that AD produces both presynaptic depression of transmitter release and postsynaptic increase in K+ conductance as well as hyperpolarization and decreased EPSP.

TL;DR: Combined antagonism of GABAA-receptors and desensitization to baclofen slowed pellet expulsion to the same extent as GABA desens itization alone, indicating that both GAB AA- and GABAB-receptor sites are involved in this modification of peristalsis by GABA.

TL;DR: It is demonstrated that, apart from its dopamine antagonistic action, buspirone acts as a stimulant and a blocker of central 5-HT and α-adrenergic receptors, respectively.

TL;DR: The differential effects of CBD suggest that the cannabinoid acts to inhibit seizure spread in the CNS by an action on GABA, but not glycine, mechanisms.

TL;DR: The release-inhibiting dopamine autoreceptors and the post synaptic dopamine receptors mediating the inhibition of acetylcholine release appear to be pharmacologically similar and can be classified as D2-receptors.

TL;DR: Acute intracerebroventricular injection of neurotensin shortly after the ingestion of a novel flavor did not produce a flavor aversion during testing 48 h later, suggesting that reduction of food intake by low doses of centrally administered neurotens in rats is not related to a conditioned taste aversion.

TL;DR: The present study investigated behavioral parallels between adaptation to stress and antidepressant treatment using the forced swim test and found that restraint stress given repeatedly for 11 days significantly reduced immobility on this test.

TL;DR: The data indicate that dynorphin-(1–13) acts as an endogenous agonist on κ-receptors, and was found to have a significant inhibitory action on the rabbit vas deferens which had been shown to contain λ-receptor exclusively.

TL;DR: It is demonstrated that Ro 15-1788 is not a pure benzodiazepine antagonist, but has partial agonist properties and blocked the anti-conflict effect of clorazepate.

TL;DR: The results suggest that the inhibitory effect of ATP on cholinergic neurotransmission is due to its rapid breakdown to AMP or adenosine, which act on prejunctional P1-purinoceptors.

TL;DR: It is indicated that the interaction of 5-hydroxytryptamine with S2-receptors of the vascular smooth muscle cells is essential to allow the expression of the monoamine-induced amplification of the response to other vasoconstrictor substances.

TL;DR: The experiments served to characterize the receptors mediating the inhibitory effect of alpha-adrenergic drugs on K+ (20 mM)-induced [3H]noradrenaline (NA) and [ 3H]5-hydroxytryptamine ([3H)5-HT) release from slices of the dorsal part of rat hippocampus, and suggest that these alpha 2- adrenoceptors are not pharmacologically identical.

TL;DR: Beta-CNA and particularly beta-FNA should prove valuable in the elucidation of multiple opioid receptors and should also be seen following administration in vivo.

TL;DR: High-affinity [3H]desipramine binding sites thus appear to be localised on Noradrenergic nerve endings and are probably closely associated with the neuronal uptake system for noradrenaline.

TL;DR: It is suggested that serotonin controls [3H]imipramine dissociation from an allosterically coupled site residing on a larger macromolecular complex.

TL;DR: The responses of the guinea-pig ileum myenteric plexus-longitudinal muscle preparation to gamma-aminobutyric acid and several analogs were examined in direct and electrically stimulated preparations, suggesting that GABA and its analogs act at a population of excitatory receptors mediating the release of acetylcholine from enteric neurons, and at apopulation of inhibitory receptors which inhibit the stimulated release ofacetylCholine.