Showing papers in "European Journal of Pharmacology in 1983"
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862 citations
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734 citations
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272 citations
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TL;DR: Data indicate that dipyridamole at therapeutic concentrations causes significant inhibition of adenosine metabolism in whole blood.
260 citations
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TL;DR: It was demonstrated that relaxation by histamine and acetylcholine of pre-contracted rat aorta segments required the presence of endothelial cells, and histamine acting on H1-receptors seemed to initiate the production of mediator(s) from the endothelium, which leads to relaxation of the vascular smooth muscle cells.
252 citations
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TL;DR: These data provide a useful map for studying the relationship between receptor-mediated and seizure-induced neuronal damage following KA administration, and one of the important factors in KA neurotoxicity seems to be the presence of KA receptors.
240 citations
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TL;DR: Changes displayed the typical features of common acute circulatory collapse with distributive and hypovolemic etiologies, suggesting that PAF-acether might be an endogenous mediator in the early and late stages of shock.
240 citations
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TL;DR: It is suggested that augmentation of GABA effects is involved in the incoordinating and soporific actions of ethanol, and one factor responsible for genetic differences in ethanol response is sensitivity to GABA; and ethanol tolerance and dependence may be related to decreased sensitivity toGABA.
213 citations
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TL;DR: The binding affinity of sufentanil for delta-type binding sites labelled by [3H] [D-Ala2,D-Leu5]enkephalin was found to be 100 times lower than its binding affinity for the mu-receptor sites.
202 citations
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182 citations
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TL;DR: Very low doses of CCK-8 related peptides exert behavioral effects following injection into the nucleus accumbens, indicating that this brain area is extremely sensitive to the action of these peptides.
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TL;DR: Generation of proinflammatory macrophage products by SP may be relevant in the context of neuroinflammatory disease.
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TL;DR: It is suggested that these three functionally distinct tissues possess the same subtype of substance P receptor coupled to inositol phospholipid hydrolysis, and that this receptor has the characteristics of the previously reported SP-P subtype.
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TL;DR: SKF 10,047, N-allylnormetazocine, a benzomorphan narcotic antagonist, and the arylcyclohexylamine anesthetic phencyclidine produced similar reflex, autonomic and behavioral effects in the chronic spinal dog which were not antagonized by naltrexone pretreatment.
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TL;DR: The results of this study suggest that the discriminative stimulus effects of DOM, the three hallucinogenic agents to which DOM-stimulus generalization occurred, and quipazine, may involve those sub-populations of serotonin receptors that are labeled by tritiated ketanserin (i.e. 5-HT2 sites).
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TL;DR: It is demonstrated that behavioral sensitization induced by methamphetamine is accompanied by increased central dopaminergic transmission.
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TL;DR: Paroxetine, one of the most potent and specific serotonin uptake inhibitors, was tritiated and used for binding studies with human platelet membranes, and specific, high affinity binding was demonstrated.
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TL;DR: C-terminal alkyl esters of substance P were found to exhibit a high degree of selectivity to one putative receptor subtype, adding support to the hypothesis that two subtypes of Substance P receptor may exist by extending the screening of tachykinins to further bioassays and by testing novel analogues.
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TL;DR: The ability of methysergide and BOL to readily antagonize the effects of intrathecal 5-HT versus the relative inactivity of spiroperidol and ketanserin, used to characterize the5-HT2 binding site, suggests the likely role of 5- HT1 receptors in mediating the spinnal effects of 4-HT in the tail flick, but not the hot plate test of nociception.
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TL;DR: It may now be possible to inhibit enzymatic degradation of opioid peptides sufficiently to measure their release from neurones activated by electrical field stimulation.
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TL;DR: The suggestion that cGMP acts as a mediator of GTN-induced vascular smooth muscle relaxation is supported, as demonstrated in this study.
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TL;DR: It is concluded that a bestatin-sensitive aminopeptidase activity together with the 'enkephalinase' activity plays a critical role in the inactivation of both exogenous and endogenous enkephalins.
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TL;DR: No correlation was observed between the potency of a series of carbamazepine analogs as inhibitors of either adenosine receptor binding and their ability to inhibit electroshock-induced convulsions, suggesting that the anticonvulsant properties of these agents are not mediated by the adenosin receptor.
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TL;DR: Locus coeruleus neurons in slices from animals treated chronically, but not subacutely, with morphine exhibited a significant decrease in sensitivity to morphine, and this tolerance appeared to be specific for opiates since no decrease was seen for the alpha 2-adrenoceptor agonist clonidine.
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TL;DR: It is concluded that bepridil and verapamil enter and accumulate in the muscle cells, whereas nifedipine and diltiazem permeate more slowly into the muscles.
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TL;DR: Results indicate that adenosine can relax the aorta via interactions with a cell surface A2 receptor and with an intracellular site.
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TL;DR: The results suggest that the dopamine autoreceptor modulating the depolarization-evoked release of [3H]dopamine, and the binding site of [ 3H]spiperone, are valid in vitro models for D2-dopamines receptors.
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TL;DR: The data suggest that azelastine inhibits A23187-stimulated histamine release by interfering with the influx of Ca2+ into the mast cells, which is antagonized by high concentrations of exogenous Ca2- ions.