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Showing papers in "European Journal of Pharmacology in 1983"





Journal ArticleDOI
TL;DR: Data indicate that dipyridamole at therapeutic concentrations causes significant inhibition of adenosine metabolism in whole blood.

260 citations


Journal ArticleDOI
TL;DR: It was demonstrated that relaxation by histamine and acetylcholine of pre-contracted rat aorta segments required the presence of endothelial cells, and histamine acting on H1-receptors seemed to initiate the production of mediator(s) from the endothelium, which leads to relaxation of the vascular smooth muscle cells.

252 citations


Journal ArticleDOI
TL;DR: These data provide a useful map for studying the relationship between receptor-mediated and seizure-induced neuronal damage following KA administration, and one of the important factors in KA neurotoxicity seems to be the presence of KA receptors.

240 citations


Journal ArticleDOI
TL;DR: Changes displayed the typical features of common acute circulatory collapse with distributive and hypovolemic etiologies, suggesting that PAF-acether might be an endogenous mediator in the early and late stages of shock.

240 citations


Journal ArticleDOI
TL;DR: It is suggested that augmentation of GABA effects is involved in the incoordinating and soporific actions of ethanol, and one factor responsible for genetic differences in ethanol response is sensitivity to GABA; and ethanol tolerance and dependence may be related to decreased sensitivity toGABA.

213 citations


Journal ArticleDOI
TL;DR: The binding affinity of sufentanil for delta-type binding sites labelled by [3H] [D-Ala2,D-Leu5]enkephalin was found to be 100 times lower than its binding affinity for the mu-receptor sites.

202 citations



Journal ArticleDOI
TL;DR: Very low doses of CCK-8 related peptides exert behavioral effects following injection into the nucleus accumbens, indicating that this brain area is extremely sensitive to the action of these peptides.

Journal ArticleDOI
TL;DR: Generation of proinflammatory macrophage products by SP may be relevant in the context of neuroinflammatory disease.

Journal ArticleDOI
TL;DR: It is suggested that these three functionally distinct tissues possess the same subtype of substance P receptor coupled to inositol phospholipid hydrolysis, and that this receptor has the characteristics of the previously reported SP-P subtype.

Journal ArticleDOI
TL;DR: SKF 10,047, N-allylnormetazocine, a benzomorphan narcotic antagonist, and the arylcyclohexylamine anesthetic phencyclidine produced similar reflex, autonomic and behavioral effects in the chronic spinal dog which were not antagonized by naltrexone pretreatment.

Journal ArticleDOI
TL;DR: The results of this study suggest that the discriminative stimulus effects of DOM, the three hallucinogenic agents to which DOM-stimulus generalization occurred, and quipazine, may involve those sub-populations of serotonin receptors that are labeled by tritiated ketanserin (i.e. 5-HT2 sites).

Journal ArticleDOI
TL;DR: It is demonstrated that behavioral sensitization induced by methamphetamine is accompanied by increased central dopaminergic transmission.

Journal ArticleDOI
TL;DR: Paroxetine, one of the most potent and specific serotonin uptake inhibitors, was tritiated and used for binding studies with human platelet membranes, and specific, high affinity binding was demonstrated.

Journal ArticleDOI
TL;DR: C-terminal alkyl esters of substance P were found to exhibit a high degree of selectivity to one putative receptor subtype, adding support to the hypothesis that two subtypes of Substance P receptor may exist by extending the screening of tachykinins to further bioassays and by testing novel analogues.

Journal ArticleDOI
TL;DR: The ability of methysergide and BOL to readily antagonize the effects of intrathecal 5-HT versus the relative inactivity of spiroperidol and ketanserin, used to characterize the5-HT2 binding site, suggests the likely role of 5- HT1 receptors in mediating the spinnal effects of 4-HT in the tail flick, but not the hot plate test of nociception.

Journal ArticleDOI
TL;DR: It may now be possible to inhibit enzymatic degradation of opioid peptides sufficiently to measure their release from neurones activated by electrical field stimulation.

Journal ArticleDOI
TL;DR: The suggestion that cGMP acts as a mediator of GTN-induced vascular smooth muscle relaxation is supported, as demonstrated in this study.

Journal ArticleDOI
TL;DR: It is concluded that a bestatin-sensitive aminopeptidase activity together with the 'enkephalinase' activity plays a critical role in the inactivation of both exogenous and endogenous enkephalins.

Journal ArticleDOI
TL;DR: No correlation was observed between the potency of a series of carbamazepine analogs as inhibitors of either adenosine receptor binding and their ability to inhibit electroshock-induced convulsions, suggesting that the anticonvulsant properties of these agents are not mediated by the adenosin receptor.

Journal ArticleDOI
TL;DR: Locus coeruleus neurons in slices from animals treated chronically, but not subacutely, with morphine exhibited a significant decrease in sensitivity to morphine, and this tolerance appeared to be specific for opiates since no decrease was seen for the alpha 2-adrenoceptor agonist clonidine.

Journal ArticleDOI
TL;DR: It is concluded that bepridil and verapamil enter and accumulate in the muscle cells, whereas nifedipine and diltiazem permeate more slowly into the muscles.



Journal ArticleDOI
TL;DR: Results indicate that adenosine can relax the aorta via interactions with a cell surface A2 receptor and with an intracellular site.

Journal ArticleDOI
TL;DR: The results suggest that the dopamine autoreceptor modulating the depolarization-evoked release of [3H]dopamine, and the binding site of [ 3H]spiperone, are valid in vitro models for D2-dopamines receptors.

Journal ArticleDOI
TL;DR: The data suggest that azelastine inhibits A23187-stimulated histamine release by interfering with the influx of Ca2+ into the mast cells, which is antagonized by high concentrations of exogenous Ca2- ions.