Showing papers in "European Journal of Pharmacology in 1984"
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TL;DR: The residual behavioural effects of 8-OH-DPAT in reserpinised rats may, therefore, reflect the consequences of stimulation of the putative 5-HT1A receptor.
689 citations
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TL;DR: The kinetic and pharmacological characteristics of the binding of ligands to frontal cortex and hippocampus demonstrated the presence of 5-HT1 and5-HT2 sites in both tissues, although hippocampus was richer in 5-ht1 (subtype 5- HT1A) sites.
602 citations
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TL;DR: Ki's for blocking uptake of norepinephrine, serotonin, and dopamine into synaptosomal preparations of rat brain were determined for 25 antidepressants and putative antidepressants, some neuroleptics, stimulants, antihistamines and other monoamines to compare the relative potencies of a drug at the three processes.
548 citations
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357 citations
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TL;DR: The hypothesis that adenosine modulates the electrophysiological responses to stimulation of stratum radiatum through a reduction of the release of the excitatory amino acids aspartate and glutamate is supported.
354 citations
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336 citations
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325 citations
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TL;DR: It is proposed that both adenosine 5'-triphosphate (ATP) and noradrenaline (NA) are involved in sympathetic neurotransmission in the rat tail artery.
312 citations
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TL;DR: Results are consistent with the hypothesis that the e.j.p.s in the guinea-pig vas deferens are mediated by ATP, acting as a cotransmitter with NA in the sympathetic nerves supplying this organ.
296 citations
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TL;DR: The results suggest that tetrazoles may produce convulsions by acting at the picrotoxin-sensitive site of the benzodiazepine-GABA receptor-ionophore complex.
295 citations
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TL;DR: The data suggest that neuroleptic drugs have two separate actions on the dopamine neuron in vivo, one causing an increase in dopamine release and another producing an increased in dopamine metabolism, which is probably a consequence of increased dopamine synthesis.
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TL;DR: Ex vivo experiments with aryl 1,4-dialkylpiperazines suggested that these compounds may have the same relative specificity as dopamine uptake blockers in vivo, and these compounds should prove to be useful pharmacological agents.
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TL;DR: The results indicate that NMPTP in the rat does not cause selective destruction of dopaminergic neurons, but it does produce acute tryptamine-like effects.
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TL;DR: Dopamine and HVA levels in the striatum of subjects with supranuclear palsy indicate that the nigrostriatal system was lesioned to the same degree in this disease as in idiopathic Parkinsonism, but spiperone binding was reduced by half in all the structures studies.
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TL;DR: In naive animals 8-OH-DPAT exerting anticonflict effects acted like a 5-HT antagonist, whereas in subchronically PCPA-pretreated animals with presumably supersensitive 5- HT receptors, 8- OH- DPAT decreasing the number of accepted shocks actedlike a 5,HT agonist.
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TL;DR: Using radioligand binding techniques, the equilibrium dissociation constants (KD's) for a series of neuroleptics at the dopamine, muscarinic, histamine H1, alpha 1- and alpha 2-adrenergic receptors of normal human brain tissue obtained at autopsy were determined.
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TL;DR: The results support the claim that the 5-HT autoreceptor has a pharmacological resemblance to the5-HT1 recognition site and in particular to the low affinity 5- HT1B subtype of this site.
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TL;DR: This first demonstration of the vascular activity of synthetic ANF depicts this substance as a nonselective vasodilator of agonist-induced contractions and suggests a common mechanism of action with sodium nitroprusside.
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TL;DR: Results indicate that remoxipride is a potent, selective D2 receptor blocking agent with a preferential action in mesolimbic and extrastriatal dopamine-containing neurons.
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TL;DR: Findings indicate that the dopamine autoreceptors decrease dopamine release in vivo by 0-50% while larger decreases probably involve postsynaptic neurons engaging short- as well as long-loop reflexes.
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TL;DR: The data indicate a neurotoxic action of NMPTP on both dopamine and noradrenaline nerve terminals in mouse brain.
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TL;DR: The results suggest that these drugs indirectly influence the activity of DA neurons and that this may be a property shared by drugs classified as sigma receptor agonists.
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TL;DR: The analgesic effect of [Met5]enkephalin was potentiated 50000 times by intracerebroventricular co-administration in mice of kelatorphan (50 micrograms), and Kelatorphan alone was at least two-fold more potent as analgesic than the above mixture of inhibitors.
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TL;DR: It is concluded that PAT is a potent 5-HT agonist acting on both post- and presynaptic 5- HT receptors in the rat brain.
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TL;DR: Both agonist and antagonist studies suggest that the rat adipocyte lipolytic receptor does not fit into the current β1/β2-adrenoceptor classification.
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TL;DR: It is concluded that circling behaviour is mediated by closely related but independent DA D-1 and D-2 receptor sites.
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TL;DR: The results indicate that 5-HT2 receptors show different pharmacological profiles in different species, and caution should be exerted in extrapolating data from laboratory animals to humans.
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TL;DR: The suitability of elicitation of the combined syndrome of yawning plus penile erections as useful behavioural model for dopamine autoreceptor agonists is discussed.