Showing papers in "European Journal of Pharmacology in 1990"

TL;DR: The hypothesis that pathways subserved by the NMDA subtype of glutamate receptors are involved in the pathophysiology of affective disorders may have heuristic value and that substances capable of reducing neurotransmission at theNMDA receptor complex may represent a new class of antidepressants is investigated.

TL;DR: A stimulation of EDRF release contributes to the LPS-induced hypotension in the anaesthetized rat, and inhibition of nitric oxide endothelium-derived relaxing factor synthesis with NG-monomethyl-L-arginine reduces this response.

TL;DR: The present data show that chronic ethanol treatment results in an increase in the number of NMDA receptor/ionophore complexes in the hippocampus, a brain area known to be associated with ethanol withdrawal seizure activity.

TL;DR: The affinities (obtained by radioligand binding studies) of the most selective tools known today for each of the 5-HT subtypes are presented and the structure-activity relationships of some interesting series are discussed.

TL;DR: The results suggest that NO as well as VIP is involved in NANC-mediated relaxations of the rat gastric fundus, and that VIP abolished the relaxant response to VIP and reduced the responses to stimulation.

TL;DR: This work reports the first evidence that IL-1 beta can regulate LTP of synaptic transmission in the hippocampus, and blocks the effect of Lys-D-Pro-Thr, a tripeptide analogue of IL- 1 beta, by concurrent application.

TL;DR: The results suggest that ACh-induced analgesia was mediated via the release of NO, and indicate that the guanylate cyclase system is stimulated in the inflammatory reaction.

TL;DR: N ω -nitro- L-arginine is 70 times more potent than N G -monomethyl- L - arginine as a specific inhibitor of EDRF formation/release.

TL;DR: Ionophoretic and behavioural experiments showed that GABAB receptors in the brain were blocked after i.p. administration of CGP 35348, which appeared to be 10-30 times more potent than the GABAB receptor blocker phaclofen.

TL;DR: The results of the present study indicate that the rank order of potency of non-peptide CCK antagonists for enhancing morphine analgesia is L- 365,260 greater than MK-329 greater than L-365,031, which suggests that CCK/opiate interactions in this species are mediated by CCK-B receptors.

TL;DR: It is suggested that EDRF/nitric oxide released from endothelium possibly contributes to inhibition of the DNA synthesis in vascular smooth muscle cells.

TL;DR: A number of compounds were characterized in detail with respect to a GTP-induced affinity shift in inhibition of [3H]SCH 23390 binding, and potency and efficacy in stimulating adenylate cyclase from rat striatum, creating a basis for selection of agonists in future characterizations of dopaminergic-mediated events.

TL;DR: It is suggested that σ receptors modulate the NMDA-induced neuronal activation in dorsal hippocampus pyramidal neurons induced by microiontopheretic application of N-methyl-D-aspartate.

TL;DR: Modafinil appears to produce a strong stimulating effect in rodents and in primates, and could be linked to modulation (stimulation) of central alpha 1-adrenoceptors unaccompanied by peripheral sympathetic effects, which is unexpected.

TL;DR: The role of local (cardiac) bradykinin in the infarct-limiting effect of the ACE inhibitor, ramiprilat, is investigated by using the novel bradykinsin antagonist, HOE 140.

TL;DR: The results suggest that endogenous NO has a modulatory role in oedema formation induced by mediators of increased microvascular permeability.

TL;DR: The loop subserving DNIC which ascends from--and redescends to--the spinal cord involves an opioidergic link in man as in experimental animals and possible implications for hypoalgesia based on the principles of counter-irritation or elicited by naloxone are discussed.

TL;DR: It is suggested that NO or a NO releasing substance mediates the NANC relaxation in the canine terminal ileum and ileocolonic junction.

TL;DR: It is concluded that mCPBG is a potent, high affinity 5-HT3 receptor agonist.

TL;DR: It is demonstrated that ethanol can potentiate IGABA in mammalian central neurons in a concentration-dependent manner in the majority of cells studied.

TL;DR: It is suggested that an interaction with 5-HT1C sites may be relevant to the mechanism of clinical action of clozapine and, perhaps, of other atypical antipsychotics.

TL;DR: In comparison to other seizure models, alcohol withdrawal seizures seem to be particularly sensitive to MK-801, suggesting that mechanisms which result in seizure susceptibility after withdrawal of chronic ethanol exposure may be dependent upon sensitization or upregulation of NMDA processes.

TL;DR: Digital fluorescence imaging is used to compare the ability of the separate enantiomers of trans-ACDP to mobilize intracellular free calcium in cerebellar granule cells, maintained in primary culture.

TL;DR: The results strongly indicate that PCP sites, but not sigma sites, are functional receptors mediating the analgesic effect of ketamine, consistent with the hypothesis that NMDA receptors are essential for pain perception in humans.

TL;DR: In this article, the anticonvulsant, memantine (1-amino-3,5-dimethyladamantane), was tested whether it can protect neurons against hypoxic or ischemic damage.

TL;DR: The results indicate that the inhibitory effects of opioids on the in vitro release of DA from dopaminergic nerve fibres arising from the substantia nigra and the ventral tegmental area are mediated by presynaptic kappa receptors only.

TL;DR: Intravenous injection of big endothelin-1 to anaesthetized rats produced a dose-dependent and long-lasting hypertensive effect, the magnitude of which was similar to that evoked by ET-1, and in animals given phosphoramidon (0.25 mg/kg per min i.v.), a metalloproteinase inhibitor, the hypertensive result was markedly attenuated.

TL;DR: It is suggested that administration of haloperidol results initially in effects mediated through both dopamine and sigma receptors, but as metabolism proceeds the sigma actions would be expected to decline at a significantly slower rate than the dopaminergic actions.

TL;DR: Pretreatment of rats with ICS 205-930 effectively attenuated the subsequent increases in dopamine, in both the nucleus accumbens and corpus striatum, which suggests that 5-HT may be involved in the effects of ethanol on dopaminergic systems.