Showing papers in "European Journal of Pharmacology in 1991"

TL;DR: It is reported here that the NO-synthase inhibitor, L-N omega-nitro-arginine, blocks LTP and that sodium nitroprusside, which releases NO, produces a long-lasting enhancement in synaptic efficacy which is not additive with tetanus-induced LTP.

TL;DR: The results indicate that 1-amino-adamantanes, in general, may produce their pharmacological effects through an interaction with the NMDA-receptor-gated ion channel and the displacement of [3H]MK-801 binding thus may provide the basis to predict the antiparkinsonian and antispastic activity of novel substituted 1-AMino- adamantane and possibly of other drugs.

TL;DR: This review summarises advances made in understanding the biochemical events which underlie the remarkable neurotoxic action of MPTP and the relevance of the MPTP model to idiopathic Parkinson's disease is discussed.

TL;DR: It was shown that in the periphery, acetylcholine-induced analgesia was mediated via the activation of the nitric oxide/cGMP pathwny (Duarte et al., I990), and intraplantar injection of sodium nitroprusside caused analgesia.

TL;DR: It is suggested that serotonergic innervation of the anterior striatum may exert a facilitatory influence on DA release in a dose dependent manner and to a greater extent than any other agonist tested.

TL;DR: The concentrations of interleukin-6 required for this stimulatory action are within the range measured in amniotic fluid of women with intrauterine infections and preterm labor, and may contribute to the mechanism of pre term labor under these conditions.

TL;DR: The most striking conclusion of this fast moving research is that the dopamine receptors are more diverse than expected from their pharmacological characterizations.

TL;DR: Although tiagabine antagonized DMCM-induced convulsions, it exhibited neither CGS 9896 or diazepam-like interoceptive effects, nor did it block (or potentiate) pentylenetetrazol-discrimination, thus, GABA uptake inhibition represents a novel rationale for a valproate-like anticonvulsant drug therapy.

TL;DR: Results suggest that [3H]CGP 39653 selectively binds to the NMDA receptor as an antagonist with high affinity and is currently the ligand of choice for labeling theNMDA receptor.

TL;DR: The data indicate that the analgesic action of opioids during conditions of inflammation may depend on an interaction with spinal noradrenergic pathways.

TL;DR: It is demonstrated the existence of a third beta-AR directly involved in adrenergic-mediated lipolysis, and identified it in the white fat cells of the most commonly studied animal species, except humans.

TL;DR: A possible role for angiotensin II as a mediator of vascular growth is suggested in chick embryo chorio-allantoic membrane from day 7 to day 14 after fertilization of the eggs.

TL;DR: In some rats, there was a persistent decrease in morphine intake for several days or weeks after a single injection of ibogaine; other rats began to show such persistent changes only after two or three weekly injections whereas a few rats were apparently resistant to prolonged aftereffects.

TL;DR: The data demonstrate that oxytocin via its central receptor can regulate the response to social isolation and is able to modulate the formation and maintenance of social bonds.

TL;DR: The results show that the potent ventilatory depression induced by morphine-6-glucuronide is related to its antinociceptive effects in rats, and indicates that morphine-3- glucuronid is a functional antagonist of the depressive effects of morphine and morphine- 6-glUCuronide on ventilation.

TL;DR: Results show that activation of spinal serotonergic systems is involved in the antinociceptive effect of paracetamol, and the relative importance of this mechanism in the central effect and the mechanisms that cause the activation remain to be determined.

TL;DR: It is concluded that the steroid modification of the GABAA receptor is strongly influenced by the alpha- and the gamma 2-subunit types.

TL;DR: The anticonvulsant actions of GYKI 52466 and NBQX suggest a possible role for non-NMDA antagonists in the therapy of epilepsy and side effects in baboons probably arose from drug formulation.

TL;DR: Finities of (±)-CP-96,345 and analogs in [ 125 I]SP binding were determined in various tissues derived from several species, indicating the existence of species differences in NK-1 receptors.

TL;DR: The results suggested that the prolongation of the transfer latency on retention testing in the plus-maze method might be used as an indicator for impairment of learning and memory induced by the drugs which have amnesic properties, and is not related to the change in transferLatencies on training.

TL;DR: Brain dialysis was used to study the changes in dopamine release in the mesolimbic ventral striatum elicited by morphine withdrawal in rats treated with morphine every 12 h for 15 days.

TL;DR: Emodin and scoparone, the active principles isolated from Polygonum multiflorum and Artemisia scoparia, respectively, both exhibit vasorelaxant and immunosuppressive effects and may be useful as new templates for the development of better immunosppressive agents with vasoreLaxant actions for use against transplantation rejection and autoimmune disease.

TL;DR: Non-competitive NMDA antagonists, like MK801, may not be useful to alleviate opiate withdrawal symptoms in man because of their PCP-like side effects, however, competitive NMDAagonists, like LY274614, could be of great benefit for alleviating opiates withdrawal Symptoms in man.

TL;DR: It is concluded that MK-801 may facilitate the activation of dopaminergic mechanisms through an indirect (perhaps by reducing glutamatergic activity) rather than a direct effect on dopamine neurons.

TL;DR: The results suggest that NO released by nerve stimulation modulates cholinergic neurotransmission in guinea-pig trachea.

TL;DR: It is concluded that rilmenidine, like clonidine, acts to lower arterial pressure by an action on imidazole receptors in the C1 area of RVL.