Showing papers in "European Journal of Pharmacology in 1992"

TL;DR: It is suggested that endogenous NO is released at the site of acute inflammation and modulates oedema formation and is predominantly generated by the constitutive or by the inducible NO synthase.

TL;DR: The administration of the NMDA receptor antagonist, MK-801, to rats withdrawn from chronic ethanol, morphine or amphetamine, but not from chronic cocaine, readily reversed the fall in DA output and the reduction in extracellular DA during ethanol withdrawal.

TL;DR: Several agonists and antagonists, previously regarded as autoreceptor-selective, displayed higher affinities at D3 than at D2 receptors, suggesting that they realize differential dopamine receptor subtype occupancy during treatments and that this might be reflected in their clinical profile.

TL;DR: In human tracheal segments, it is demonstrated that this response is mediated entirely by nitric oxide, since an inhibitor of NO synthesis, L-NG-nitroarginine methyl ester (L-NAME) (10(-4) M) abolishes this neural response.

TL;DR: Results suggest that the serotonergic system may be involved in modulating stress and corticosterone effects on dendritic morphology and that tianeptine is known to enhance neural uptake of serotonin.

TL;DR: PPADS is a novel and useful pharmacological tool to study co-transmission in tissues where ATP and co-existing neurotransmitters act in concert.

TL;DR: The results suggest that NMDA-produced facilitation of a thermal nociceptive reflex is mediated through activation of an NMDA receptor that results in an increase in endogenous nitric oxide and activation of soluble guanylate cyclase in lumbar spinal cord.

TL;DR: Hydroxylamine (1-300 microM) stimulated the release of [3H]norepinephrine and [14C]acetylcholine from rat hippocampal slices in a concentration-dependent manner and increased the efflux of endogenous GABA and glutamate by 3- and 6-fold, respectively.

TL;DR: Results confirm that 5- HT uptake inhibitors preferentially increase extracellular concentrations of 5-HT in the vicinity of cell bodies and dendrites of serotonergic neurones.

TL;DR: The paw withdrawal latencies of the carrageenan-injected paws were elevated dose dependently and the rank order of potency of these agents to reduce hyperalgesia was: MK-801 greater than or equal to AP-5 greater than and equal to CPP = 7-Cl kynurenic acid = ketamine much greater than CNQX greater than 0.20 ml saline.

TL;DR: The hypothesis that activation of the nitric oxide-cGMP pathway is involved in the mechanism of two directly acting non-opiate peripheral analgesics, myrcene and dipyrone, is supported using the modification of the Randall-Selitto test.

TL;DR: Ucb L059 presents as an orally active, safe, broad-spectrum anticonvulsant agent, with potential antiepileptogenic and anti-absence actions.

TL;DR: The results suggests that MDMA, methamphetamine, PCA and fenfluramine cause 5-HT release via a common mechanism and indicates that the 5- HT uptake blockade induced by these substituted amphetamines in vitro is different from that induced by either fluoxetine or cocaine.

TL;DR: Haloperidol, (+-pentazocine, (+)-3-(3-hydroxyphenyl)-N-propylpiperidine and rimcazole were competitive inhibitors of binding to the [ 3 H](+)-pentazOCine-defined σ recognition site, suggesting that these different structural classes of compounds all bind to a single molecular entity.

TL;DR: In conscious rats, the basal forebrain was superfused through a push-pull cannula and the release of acetylcholine was determined in the superfusate and it was concluded that endogenous NO enhances the release from its neurons.

TL;DR: The two glycine site antagonists tested, 7-chlorokynurenic acid (7-Cl-Kyn) and (+/-)-3-amino-1-hydroxy-2-pyrrolidone (HA-966), the effect was compatible with selective action at the NMDA receptor complex while the action of the former was comparable to those of non-selective excitatory amino acid (EAA) receptor antagonists.

TL;DR: It is suggested that morphine tolerance involves the activation of NMDA receptors followed by the subsequent release of nitric oxide, and the demonstration of appreciable tolerance for at least 11 days.

TL;DR: Observations suggest that 5-HT1A receptors in the brain participate in the regulation of the circadian rhythm of wheel-running activity in hamsters.

TL;DR: Tiagabine acts as a GABA uptake inhibitor in vivo also and increases the extracellular concentrations of GABA in globus pallidus and substantia nigra of awake Sprague-Dawley rats.

TL;DR: The data indicate that, in addition to catecholaminergic systems, serotonergic neurotransmission is significantly involved in the mechanisms by which MK-801 alters behaviour in rats.

TL;DR: It is proposed that the weak cation selectivity of the magainin channels can be accounted for by the inclusion of negatively charged lipids in the channel complex and suggest two possible structures for such a channel.

TL;DR: It is concluded that the gp120-induced apoptosis may contribute to the neurological complications frequently associated with the immunodeficiency syndrome and the cytoprotective effect of memantine in cortical cell cultures may qualify the drug for the treatment of AIDS-related dementia.

TL;DR: The fact that there was no correlation of the binding or in vivo data for BNTX with antagonist potency in smooth muscle preparations suggest that the in vitro pharmacologic activity is mediated by δ-opioid subtypes that are different from those in the brain.

TL;DR: It is concluded that CP-96,345 may act as an antagonist of L-type Ca2+ channels in addition to being a potent NK1 receptor (substance P) antagonist.

TL;DR: Individual or dual methionine mutations in positions 116 and 117, to make the dopamine D2 binding pocket more closely resemble the beta 2-adrenoceptor, did not result in a change in selectivity toward noradrenergic agonists or antagonists.

TL;DR: The results suggest a permissive role for 5-HT2 receptors in the activation of the dopamine system which occurs during states of high serotonergic activity or during conditions of elevated dopamine efflux with high D2 receptor occupancy.

TL;DR: Following acute (3-h) in vivo pretreatment with NNC-711, behavioral tolerance developed to its motor impairing side effects (inhibition of traction, rotarod or exploratory locomotor activity) without corresponding tolerance to the anticonvulsant effects.

TL;DR: A role for NO in vivo in mediation of gastric mucus release is implied, along with the presence of NO synthase in the Gastric mucosa, imply a role forNO in vivo on the basis of dose-related increase in mucus gel thickness.

TL;DR: This article assessed the effect of a GABAB agonist, baclofen and a specific GABAB antagonist in two pharmacologic models of absence seizures in rodent after using either γ-hydroxybutyrate or pentylenetetrazole to induce the bilaterally synchronous spike wave discharges that typify absence seizures.

TL;DR: It is shown that direct infusion of an antisense oligodeoxynucleotide to c-fos into striatum will reduce amphetamine-induced production of Fos-like immunoreactivity without affecting NGFI-A expression.