Showing papers in "European Journal of Pharmacology in 1993"

TL;DR: It is demonstrated that aminoguanidine selectively inhibits the cytokine-inducible isoform of NO synthase which appears to be responsible for the excess production of NO linked to these disease states.

TL;DR: Anandamide administered i.p. in mice, caused lowering of activity in an immobility and in an open field test, and produced hypothermia and analgesia, which parallel those caused by psychotropic cannabinoids.

TL;DR: SR140333 potently, selectively and competitively inhibited substance P binding to NK1 receptors from various animal species, including humans, and exerted highly potent antagonism towardNK1 receptors in vitro and in vivo.

TL;DR: The partial agonistic activities of antihormones in this assay suggest a direct interaction ofAntihormone-receptor complexes with the response elements on the DNA, which contributes to the understanding of antiHormone pharmacology and increases understanding of the role of human mineralocorticoid and glucocortioid receptors in physiological processes during different endocrine states.

TL;DR: Findings indicate that human adrenomedullin is a potent vasodilator and may have some role in the regulation of blood pressure.

TL;DR: The data indicate that ucb L059 is an interesting new anticonvulsant agent with a broad spectrum of activity and high therapeutic index, and was ineffective in the traditional maximal electroshock seizure and s.c.v. PTZ seizure tests in mice and rats.

TL;DR: In isolated rat aorta quercetin produced a vasodilator effect that seems to be mainly related to the inhibition of protein kinase C, and since this drug exerts multiple biochemical effects, inhibition of other transduction pathways may be involved in this effect.

TL;DR: It is demonstrated that 10-30 microM riluzole reduces the K(+)-evoked release of glutamate and aspartate from slices of hippocampal area CA1, and higher concentrations reduced gamma-aminobutyrate release.

TL;DR: Evidence is provided for the existence in brain of a novel binding site that may mediate the anticonVulsant effects of gabapentin and other potential anticonvulsant compounds.

TL;DR: Two phenylglycine derivates competitively antagonised (1S,3R)-1-aminocyclopentane-1,3-dicarboxylate (ACPD) and selectively depressed synaptic excitation in thalamic neurones evoked by noxious thermal stimuli, without affecting the synaptic stimulation of the same cells by non-noxious stimuli.

TL;DR: It is suggested that central nicotinic receptors are involved in the expression of emotional behavior and the anxiolytic-like properties of nicotine and lobeline in mice are demonstrated, and Nicotinic receptor antagonists on their own did not modify the behavior of mice in the maze.

TL;DR: Data indicate that (+/-)-WAY100135 is the first highly selective antagonist at both somatodendritic and postsynaptic 5-HT1A receptors.

TL;DR: NBQX when given 4, 6 or 24 h after ischaemia gave a reduced loss of hippocampal CA1 neurones compared to control animals receiving vehicle only, and antagonists of non-NMDA glutamate receptor subtypes, possibly AMPA, may be a useful therapeutic approach for cerebral ischaemic-related brain damage following global ischaems.

TL;DR: A direct but non-competitive action of riluzole on ionotropic glutamate receptors is suggested, similar to that of the channel blocker MK-801.

TL;DR: The present results indicate that noradrenergic neurons modulate the dopamine cell firing pattern via excitatory postsynaptic alpha 1-adrenoceptors, which might be involved in the pathogenesis and pharmacological treatment of schizophrenia.

TL;DR: It is concluded that endogenous NO plays an important role in the maintenance of blood flow around the ulcer, in the angiogenesis in the granulation tissue and in the healing of gastric ulcers.

TL;DR: EETs may promote vasodilation by functioning as endogenous K+ channel openers by interacting with receptor-mediated nature in cells from rabbit portal vein, rat caudal artery, guinea pig aorta and porcine coronary artery.

TL;DR: Evidence is provided that ethanol-induced activation of the mesolimbic dopamine system (increased dopamine synthesis and release) may be mediated via stimulation of central nicotinic acetylcholine receptors, suggested to be useful in the treatment of alcoholism.

TL;DR: The present findings suggest that the ultrasonic vocalization model specifically measures anxiolytic effects, and appears suitable for rapid and repeated testing of new anxIOlytics in the same animals.

TL;DR: The results indicate that ibogaine or its metabolite(s) is a long-lasting interruptor of cocaine dependence, which supports similar observations from uncontrolled clinical studies.

TL;DR: It is indicated that N,N'-diaminoguanidine, while approximately 30 times less potent than aminogsuanidine in inhibiting inducible NO synthase, has very little effect on constitutive No synthase activity.

TL;DR: In rats naive to handling, but not in handling-habituated animals, baclofen and (R,S) zacopride had significant anxiolytic effects, shown by an increased percentage of time spent on the open arms of the elevated plus-maze.

TL;DR: It is concluded that antagonists of the NMDA receptor-channel complex abolish the PrionSc-induced neuronal injury in vitro, and display no influence on the synthesis and/or the processing of Prion Sc.

TL;DR: Results indicated that the analgesic activity of epibatidine is attributed to its unique property as the most potent nicotinic acetylcholine receptor agonist.

TL;DR: The results of experiments using [3H]gabapentin with homogenates of rat brain show the discrete localization of this novel binding site in regions associated with excitatory amino acid input and do not support previous indications of an association of the gabapents binding site and NMDA/glycine receptor complex.

TL;DR: The anti-emetic effects of a NK1 receptor antagonist (racemic CP-99,994) in the ferret was effective against a range of emetogens, comprising cytotoxic drugs, radiation, morphine, ipecacuanha and copper sulphate.

TL;DR: In this article, a modified microdialysis procedure was used to confirm that intrastriatal administration of 1-methyl-4-phenylpyridinium ion (MPP+) induced a sustained overflow of dopamine accompanied by increased formation of hydroxyl free radicals.

TL;DR: TEI-6720 may be useful for the treatment of hyperuricemia, and its effects with those of allopurinol in rodents are compared.

TL;DR: The data suggest that acamprosate reduces the postsynaptic efficacy of excitatory amino acid neurotransmitters and lowers neuronal excitability in the neocortical neurons of the rat.

TL;DR: The polymerase chain reaction has been employed to isolate a cDNA encoding a functional 5-HT3 receptor subunit from the murine neuroblastoma cell line N1E-115, and the amino acid sequence predicted from this clone demonstrates a 98% homology with the 5- HT3 receptor A subunit cloned from NCB-20 hybrids.