Showing papers in "European Journal of Pharmacology in 2007"

TL;DR: The modulation of iNOS, COX-2 and CRP by quercetin or kaempferol may contribute to the anti-inflammatory effects of these two structurally similar flavonoids in Chang Liver cells, via mechanisms likely to involve blockade of NF-kappaB activation and the resultant up-regulation of the pro-inflammatory genes.

TL;DR: Findings indicate that alpha-humulene and (-)-trans-caryophyllene, derived from the essential oil of C. verbenacea, might represent important tools for the management and/or treatment of inflammatory diseases.

TL;DR: Evidence is provided that tan protects cardiac myocytes against oxidative stress-induced apoptosis and is mediated by increased scavenging of oxygen free radicals, prevention of lipid peroxidation and upregulation of the Bcl-2/Bax ratio.

TL;DR: A potential for therapeutic use of cannabidiol in chronic painful states is indicated after the compound's efficacy on neuropathic pain was not accompanied by any reduction in nuclear factor-kappaB activation and tumor necrosis factor alpha content.

TL;DR: The results suggest that some designer drugs strongly act on the central nerve system to the same extent as restricted drugs.

TL;DR: The results suggest that salidroside has protective effects against oxidative stress-induced cell apoptosis, which might be a potential therapeutic agent for treating or preventing neurodegenerative diseases implicated with oxidative stress.

TL;DR: The findings indicate that preemptive and repeated administration of glial inhibitors suppresses development of allodynia and hyperalgesia and potentiates effects of morphine in rat and mouse models of neuropathic pain.

TL;DR: The results from the present study indicate that silymarin exhibits good hepatoprotective and antioxidant potential against diethylnitrosamine induced hepatocellular damage in rats.

TL;DR: The results emphasize the involvement of cholinergic dysfunction, oxidative stress and inflammation in the development of cognitive impairment in diabetic animals and point towards the potential of curcumin as an adjuvant therapy to conventional anti-hyperglycemic regimens for the prevention and treatment of diabetic encephalopathy.

TL;DR: It is concluded that curcumin ameliorates cerebral ischemia/reperfusion injury by preventing ONOO(-) mediated blood-brain barrier damage.

TL;DR: Antiinflammatory and immunomodulatory properties have been observed for 5-HT3-receptor antagonists which might explain promising findings in systemic sclerosis and other immunological conditions.

TL;DR: TAK-242 protects mice against LPS-induced lethality by inhibiting production of multiple cytokines and NO and provides significant benefits by post-treatment, suggesting that it may be a promising drug candidate for the treatment of sepsis.

TL;DR: The present study provides further support that selective PDE-Is can influence memory consolidation in a time-dependent manner, assumingly by elevating central cAMP and cGMP levels.

TL;DR: It is shown here for the first time, that prophylactic use of curcumin may effectively rescue islets from damage without affecting the normal function of these cellular structures.

TL;DR: The findings suggest that the therapeutic efficacy of fluoxetine may be mediated, at least partially, via reversal of oxidative damage as demonstrated by protective enhancement of antioxidant status following a stress-induced decline.

TL;DR: It is suggested that lurasidone is superior to other antipsychotics in improving the MK-801-induced memory impairment and may be clinically useful for treating cognitive impairments in schizophrenia.

TL;DR: An updating of the current models interpreting the role of the main components of pulmonary surfactant is carried out as a reference to evaluate the biochemical composition of the preparations of exogenous natural pulmonary Surfactant currently in use and their apparent pharmacological effect.

TL;DR: It is found that fluvastatin and pravastatin significantly inhibited Pi-induced apoptosis and calcification in a concentration-dependent manner in human aortic smooth muscle cells (HASMC), as was found with atorvastasin previously.

TL;DR: It is demonstrated that the Rho/Rho-kinase pathway is involved in up-regulation of TGF-beta, CTGF and NAD(P)H oxidase in diabetic kidney and suppression of the RHo/RHo-kinases pathway could be a new strategy for the treatment of diabetic nephropathy.

TL;DR: It is concluded that the cytotoxic effect of andrographolide on HepG2 cells is primary attributed to the induction of cell cycle arrest via the alteration of cellular redox status.

TL;DR: Findings indicate that histamine H4 receptors participate in the early phase of acute inflammation induced by carrageenan in rats, influencing both edema and thermal hyperalgesia.

TL;DR: Arodyn pretreatment suppressed stress-induced, but not cocaine-exposed, reinstatement of cocaine place preference, verifying that arodyn and other kappa-opioid receptor antagonists may be useful therapeutics for cocaine abuse.

TL;DR: It appears that parenteral TLR2/4 agonists seem promising molecules to prolong survival in cancer patients who relapse under chemotherapy, because they induce a well controlled tumor necrosis factor-alpha (TNF-alpha) secretion and activates dendritic cell traffic and its associated tumor-specific, cytotoxic T-cell responses.

TL;DR: The modulation of intra and extracellular zinc alone is sufficient to induce metabolic changes or even apoptosis in two model human breast cancer cell lines MCF-7 and MDA-MB468, demonstrating that oxidative stress is the likely mediator of Zn-deficiency-related cell death.

TL;DR: The study indicated that bupropion possesses antidepressant activities in different animal models of depression through its dopaminergic and/or by modulating the L-arginine-nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling pathway.

TL;DR: Resveratrol can act as an insulin-secretagogue through I(KATP and I( KV) inhibition which can contribute to plasma glucose lowering effect in normal rats.

TL;DR: The data suggest that simvastatin may be used as a therapeutic agent in asthma, based on reductions of various allergic responses via regulating small G proteins/MAP kinases/NF-kappaB in mouse allergic asthma.

TL;DR: It is demonstrated here that piperine inhibits adhesion of neutrophils to endothelial monolayer and a possible mechanism of anti-inflammatory activity of p Piperine is suggested, which could be used for the development of new anti- inflammatory molecules.

TL;DR: The results suggest that the ethanol extract of E. rutaecarpa and its four bioactive components all exhibited anti-inflammatory activities which could be partially explained by their different potentials for inhibiting NADPH oxidase-dependent reactive oxygen species and/or iNOS-dependent NO production in activated inflammatory cells.

TL;DR: Results indicate that diphenyl diselenide produced antinociception in several models of pain through mechanisms that involve an interaction with not only nitrergic system but also via interaction with redox modulatory sites of glutamate receptors.