Showing papers in "European Journal of Pharmacology in 2008"

TL;DR: The adaptive plasticity of chronic stress involves many mediators, including glucocorticoids, excitatory amino acids, endogenous factors such as brain neurotrophic factor (BDNF), polysialated neural cell adhesion molecule (PSA-NCAM) and tissue plasminogen activator (tPA), which leads to a different way of regarding more holistic manipulations.

TL;DR: The mechanism by which quercetin may operate as an antioxidant as well as the potential use of this antioxidant as a nutraceutical (tested both ex vivo and in vivo) will be discussed.

TL;DR: Evidence is presented suggesting that interactions between stress-related neurotransmitters that converge on locus coeruleus neurons regulate shifts between these modes of discharge in response to the challenge of a stressor.

TL;DR: It is suggested that pirfenidone exerts its antifibrotic effect through regulation of lung IFN-gamma, bFGF and TGF-beta1 levels during the development of bleomycin-induced pulmonary fibrosis in mice.

TL;DR: It is concluded that both CRH(1) receptor antagonists have psychotropic effects unrelated to their neuroendocrine action, which is in line with behavioral data obtained from transgenic mice.

TL;DR: Results demonstrate that resveratrol exerts a neuroprotective effect on 6-OHDA-induced Parkinson's disease rat model, and this protection is related to the reduced inflammatory reaction.

TL;DR: It is shown that vascular risk factors should be regarded as a major target for preventive measures, but that timing of such measures appears to be critical.

TL;DR: It is demonstrated that moderately elevated corticosterone for a prolonged period is sufficient to induce cellular changes in the hippocampus that are prevented by chronic administration of antidepressants.

TL;DR: Resveratrol could be a useful drug for the protection of liver cells from oxidative stress induced damage and is shown to have many biological properties, including antioxidant activity.

TL;DR: It is suggested that the repeated corticosterone injection paradigm provides a useful and reliable mouse model within which to further study the role of stress and glucocorticoids in depressive illness, as well as screen for antidepressants or preventive drugs.

TL;DR: The studies demonstrate that all 3 compounds are potent inhibitors of the kinase activity of both DDR1 and DDR2, which may have therapeutic implications in a number of inflammatory, fibrotic and neoplastic diseases.

TL;DR: It is demonstrated that TAK-242 is a selective inhibitor of Toll-like receptor (TLR)-4 signaling and represents a novel therapeutic approach to the treatment of TLR4-mediated diseases.

TL;DR: Collectively, Artepillin C showed anti-inflammatory effects mediated, at least in part, by prostaglandin E(2) and nitric oxide inhibition through NF-kappaB modulation, and exhibited bioavailability by oral administration.

TL;DR: The results suggest that the anti-inflammatory properties of ILG are caused by iNOS, COX-2, TNF-alpha, and IL-6 down-regulation due to NF-kappaB inhibition via the suppression of IKK, ERK1/2 and p38 phosphorylation in RAW 264.7 cells.

TL;DR: In the rat there is an approximately hourly rhythm of corticosterone secretion, which appears to be regulated by alternating activation and inhibition of the HPA axis.

TL;DR: In this paper, riluzole significantly increased glutamate uptake in a dose-dependent manner; kinetic analysis indicated that the apparent affinity of glutamate for the transporters was significantly increased, with similar effects in the three cell lines.

TL;DR: A better understanding of the corticosteroid actions could lead to a more rational treatment strategy of stress-related disorders, and help to normalize hippocampal activity some hours after the stressful event.

TL;DR: This concept proposes that the combination of defective pancreatic beta-cell function and insulin resistance not only in classical insulin target tissues but in every tissue, contributes to the onset of the disease.

TL;DR: In vitro results are the first that show that the anti-inflammatory properties of schisandrin result from the inhibition of nitric oxide production, prostaglandin E(2) (PGE(2)) release, cyclooxygenase-2 (COX-2) and inducible Nitric oxide synthase (iNOS) expression.

TL;DR: Results indicate that the antidepressant-like effect of curcumin in the forced swimming test is related to serotonergic system and may be mediated by, at least in part, an interaction with 5- HT(1A/1B) and 5-HT(2C) receptors.

TL;DR: It is demonstrated that berberine exerted antidepressant-like effect in various behavioural paradigms of despair possibly by modulating brain biogenic amines (norepinephrine, serotonin and dopamine) through nitric oxide pathway and/or sigma receptors.

TL;DR: A glimpse of the history as well as up to date information that is pertinent to cytokines and anti-cytokine therapies in the treatment of cancer, autoimmune disorders and various other related diseases is presented.

TL;DR: Evidence is provided that dysregulation of MR and GR are causative in the pathogenesis of depression and that these MR-and GR-gene variants are part of the genetic make up that determines individual stress-responsivity and coping style, affecting vulnerability to disease.

TL;DR: By a common mechanism of reducing the retrieval of aversive memories, glucocorticoids may be suited for the treatment of PTSD as well as phobias, first evidence to support this hypothesis is found.

TL;DR: The results indicated the antidepressant-like effect of the ethanolic extract of S. molle in the tail suspension test may be dependent on the presence of rutin that likely exerts its antidepressant- like effect by increasing the availability of serotonin and noradrenaline in the synaptic cleft.

TL;DR: The results indicated that aucubin may have value as a safe preventive or therapeutic agent against diabetes mellitus.

TL;DR: The implication of these associations is that a large proportion of the world population may be at increased risk of Alzheimer's disease given the trends for increasing prevalence of overweight, obesity, hyperinsulinemia, and diabetes.

TL;DR: An overview of the current status of the field on identification of central corticosteroid targets is given, the opportunities and pitfalls are discussed and new developments in understanding central glucocorticoid action are highlighted.

TL;DR: The immunosuppressive effects of CP-690550, a novel, small molecule inhibitor of JAK-3, in a murine model of allergic pulmonary inflammation support the participation of Jak-3 in processes that contribute to pulmonary eosinophilia in the allergic mouse model.

TL;DR: Results demonstrate for the first time that GLP-1 not only directly modulates neurotransmitter release and LTP formation, but also protects synapses from the detrimental effects of beta-amyloid fragments on LTP Formation.