Showing papers in "European Journal of Pharmacology in 2012"

TL;DR: Evidence of the potency and mode of action of dihydroquercetin are brought together and a role for the therapeutic potential of flavonoid antioxidants is proposed.

TL;DR: It is shown that cannabidiol has anti-inflammatory effects in a murine model of acute lung injury and that this effect is most likely associated with an increase in the extracellular adenosine offer and signaling through adenosines A(2A) receptor.

TL;DR: Significant changes in protein levels were identified by two-dimensional gel electrophoresis and mass spectrometry and sigma-1 receptor mediated activation of the antioxidant response element (ARE) to upregulate NAD(P)H quinone oxidoreductase 1 (NQO1) and superoxide dismut enzyme 1 (SOD1) mRNA expression in COS cells was shown by RT PCR.

TL;DR: It is suggested that omentin inhibits TNF-α-induced VCAM-1 expression via preventing the activation of p38 and JNK at least in part through inhibition of superoxide production.

TL;DR: It appears that the crossroads of acute and delayed emeses include interactions among the 5-HT(3) and NK(1) receptor neurotransmitter pathways and that inhibitions of these interactions lend the possibility of improved treatment that encompasses both acute and delay emesis.

TL;DR: The results suggest that chrysin may have therapeutic potential for the treatment of neurodegeneration and dementia caused by decreased cerebral blood flow, which is most likely related, at least in part, to its anti-inflammatory and antioxidant properties.

TL;DR: Investigation of whether CGA has protective effects against cerebral ischemia and whether these effects are due to modification of brain edema-related vascular factors suggests that CGA reduces brain damage, BBB damage andbrain edema by radical scavenging activity and the inhibitory effects on MMP-2 and MMP9.

TL;DR: Treatment with crocetin can provide protection against LPS-induced acute lung injury in mice, and reduces phospho-IκB expression and NF-κB activity in L PS-induced lung tissue alteration.

TL;DR: The results demonstrated that sanguinarine inhibited the activation of mitogen-activated protein kinase (MAPK), which altered inflammatory mediator synthesis and release in vitro and in vivo and provided clarification of the molecular mechanisms underlying the anti-inflammatory activity of sanguinine.

TL;DR: Significant changes in the reactivity of glial cells during the development of peripheral neuropathy induced by paclitaxel are confirmed and support a preventive effect of WIN 55,212-2, probably viaglial cells reactivity inactivation, on theDevelopment of this neuropathy.

TL;DR: Results suggest that stigmasterol-induced cognitive ameliorative effects are mediated by the enhancement of cholinergic neurotransmission system via the activation of estrogen or NMDA receptors.

TL;DR: The effects of intrathecal injection of a Toll-like receptor (TLR4) inhibitor epigallocatechin gallate on neuropathic pain induced by chronic constriction injury of the sciatic nerve are investigated and the therapy targeting TLR4 might be a novel strategy in the treatment of neuropathicPain.

TL;DR: Sch B may exert neuroprotective activity by attenuating the microglial-mediated neuroinflammatory response by inhibiting the TLR4-dependent MyD88/IKK/NF-κB signaling pathway.

TL;DR: It is shown that ferulic acid and resveratrol exerted antioxidant as well as anti-diabetic effects, consequently alleviate liver, kidney and pancreas damage caused by alloxan-induced diabetes, probably through inhibition of the proinflammatory factor, NF-κB.

TL;DR: Overall results suggest that [6]-gingerol has potential to bind with DNA and induce cell death by autophagy and caspase 3 mediated apoptosis.

TL;DR: SIRT1 protects against the inflammatory response induced by IL-1β in articular chondrocytes and merits consideration as a therapeutic agent in the treatment and prevention of osteoarthritis.

TL;DR: Berberine has the ability to cause cell cycle arrest, induce apoptosis and inhibit inflammation in colon cancer cells, and the magnitude of the effects observed suggests that this compound may be worth considering for further studies of its potential applications for improving health.

TL;DR: A potential therapeutic value of fisetin in the treatment of asthma through negative regulation of NF-κB pathway is implicate.

TL;DR: Asiatic acid protects neurons from C(2)-ceramide-induced cell death by antagonizing mitochondria-dependent apoptosis, and partly counteracted the pro-apoptotic effects of the C-ceramide by reducing the cytosolic release of HtrA2/Omi and the upregulation of Bax and caspase 3.

TL;DR: In vivo study showed that bufotalin significantly inhibited the growth of xenografted R-HepG2 cells, without body weight loss or marked toxicity towards the spleen, indicating thatbufotalin has a promising potential to become a novel anti-cancer agent for the treatment of liver cancer with multidrug resistance.

TL;DR: The results indicated that (Val(8)GLP-1 might prevent age-related neurodegenerative changes by preventing decline of learning and memory formation, reduction of phosphorylated tau levels and protection of subcellular structures and morphology of neurons.

TL;DR: Evidence is provided that nanopolymeric curcumin exerts a significant chemopreventive effect on AOM-initiated colon cancer through cell proliferation inhibition and apoptosis induction and more investigations are needed to confirm its safety for human use.

TL;DR: It is demonstrated that ferulic acid exerts antidepressant-like effect in the FST and TST in mice through modulation of the serotonergic system.

TL;DR: It is suggested that diosgenin could have a beneficial role against aortic damage induced by oxidative stress in diabetic state, which was evidenced by the propensity of diOSgenin to modulate the antioxidant defense and to decrease the lipid peroxidation in aorta.

TL;DR: The present review shall familiarize the readers with the role of renin-angiotensin aldosterone system (RAAS), which regulates blood pressure, electrolyte and fluid homeostasis, and there exists a complete pancreatic RAAS which has multi-facet role in diabetes and cardiovascular diseases.

TL;DR: It is concluded that Rg3 effectively suppresses migration of PC-3M cells by down-regulating AQP1 expression through p38 MAPK pathway and some transcription factors acting on the AQP 1 promoter.

TL;DR: Results showed that biochanin A has potential antihyperglycemic activity at a dose of 10mg/kg bodyweight in streptozotocin induced diabetic rats, and protection against body weight loss of diabetic animals by biochan in A was observed.

TL;DR: The results suggest that phytochemicals such as nimbolide that can target multiple steps along the NF-κB signaling circuit are promising candidates for future phytochemical-based mechanistic pathway targeted anticancer regimens.

TL;DR: It was shown that the ligand was capable of inhibiting the action of topoisomerase II, but this was lost following complexation, which suggests that TV117-FM may have a therapeutic role to play in the treatment of hepatocellular carcinoma.

TL;DR: It is demonstrated that quercetin decreased the inflammatory status in skeletal muscle of obese mice and in L6 myotubes, which was followed by increased muscle GLUT4, with parallel improvement of insulin sensitivity.