Showing papers in "European Journal of Pharmacology in 2015"

TL;DR: The thesis argued here is that the brain has specific neurochemical neurocircuitry coded by the hedonic extremes of pleasant and unpleasant emotions that have been identified through the study of opponent processes in the domain of addiction.

TL;DR: Clinical trials with respect to neurological disorders need to be undertaken to exploit the beneficiary effects of berberine against serious disorders such as Alzheimer's and Parkinson's disease and to draw a complete safety profile of berbertine and strengthen its applicability.

TL;DR: EAE is the model which better reflects the autoimmune pathogenesis of MS and is extremely useful to study potential experimental treatments and both TMEV and toxin-induced demyelination models are suitable for characterizing the role of the axonal injury/repair and the remyelinated process in MS.

TL;DR: Osteoblast-specific BCL2 transgenic mice, in which the osteocyte network is completely disrupted, can be a mouse model for the evaluation of osteocyte functions and markedly reduces cancellous bone in humans and large animals, but not consistently in rodents.

TL;DR: The author's contributions over the last 40 years in the role of serotonin in depression, aggression, anxiety, stress and sexual behavior are outlined and each area delineates the work performed on animal model development, drug discovery and development is outlined.

TL;DR: Data show that myrcene has significant anti-inflammatory and anti-catabolic effects in human chondrocytes and, thus, its ability to halt or, at least, slow down cartilage destruction and osteoarthritis progression warrants further investigation.

TL;DR: These studies of ΔFosB are providing new insight into the molecular basis of depression and antidepressant action, which is defining a host of new targets for possible therapeutic development.

TL;DR: Counter-regulatory signaling by LXA4 and 15-epi-LXA4 follows the activation of a G protein-coupled receptor, termed ALX/FPR2, which is emerging as a key anti-inflammatory receptor.

TL;DR: An intriguing brain area is paid attention to, the ventrolateral part of the ventromedial hypothalamic nucleus (VMHvl), apparently functioning in both sexual and aggressive behavior, which are at first view completely opposite behavioral systems.

TL;DR: Increased investment and activity in the 3Rs is delivering new research models, tools and approaches with reduced reliance on animal use, improved animal welfare, and improved scientific and predictive value.

TL;DR: In this paper, the effects of berberine, a natural extract from Rhizoma coptidis, on the I/R-induced excessive autophagy in in vitro and in vivo models were investigated.

TL;DR: Naringenin pretreatment attenuates Aβ-induced impairment of learning and memory through mitigation of lipid peroxidation and apoptosis and its beneficial effect is somewhat mediated via estrogenic pathway.

TL;DR: In this review, the current knowledge on the relationship between the remodeling of cardiac gap junctions and cardiac diseases are summarized.

TL;DR: Drugs and drug classes that directly target these GPCRs to modulate cardiac function, as well as molecules involved in cardiac GPCR signaling that have the potential of becoming novel drug targets for modulation of cardiac function in the future are highlighted.

TL;DR: It is demonstrated that caffeic, coumaric and ferulic acids may participate as active ingredients in anticancer agents against lung and colon cancer development, at adhesion and migration steps of tumor progression.

TL;DR: The role of the mitochondrial fusion and fission proteins are reviewed as novel therapeutic targets for treating cardiovascular disease.

TL;DR: The results suggest that a dietary supplement of nuciferine rich in lotus leaf may be potential for the prevention and treatment of hyperuricemia with kidney inflammation.

TL;DR: The genetic studies of obesity and metabolic syndrome have identified novel molecules acting on the hunger and satiety peptidergic signaling of the gut-hypothalamus axis or the melanocortin system of the brain and are promising targets for future drug development.

TL;DR: Investigating the protective effect of telmisartan in cisplatin-induced nephrotoxicity model in rats showed maximum nephroprotective effect which could be due to maintenance of cellular redox status and inhibition of MAPK activation.

TL;DR: Ginsenoside Rg1 is metabolized to 20(S)-protopanaxtriol via ginsenosides Rh1 and F1 and these metabolites particularly 20( S)-protopsriol, may ameliorate inflammatory disease such as colitis by inhibiting the binding of LPS to TLR4 on macrophages and restoring the Th17/Treg imbalance.

TL;DR: The possibility of eliciting a synergistic bronchodilator effect when combining a LABA and a LAMA suggests that the therapeutic approach proposed by GOLD recommendations to only use LABA/LAMA combination in more severe COPD patients who are not controlled by a single bronchODilator should be reconsidered.

TL;DR: Investigation in diabetic rats found that metformin is able to attenuate diabetes-induced hyperalgesia and allodynia, which might be associated its anti-oxidative effect through AMPK pathway, and might be used as an effective drug for abnormal sensation in painful diabetic neuropathy.

TL;DR: The findings suggest the therapeutic potential of ipragliflozin for patients with NAFLD and suggest a prophylactic effect on liver fibrosis as indicated by a marked decrease in hydroxyproline content and fibrosis score.

TL;DR: It is indicated that CS-3150 is a selective and highly potent mineralocorticoid receptor antagonist with long-lasting oral activity and could be useful for the treatment of hypertension, cardiovascular and renal disorders.

TL;DR: Investigation of the effect of treatment with NGEN on oxidative events and the molecular mechanisms underlying inflammatory changes triggered in the rat liver by a high cholesterol diet for 90 days found that NGEN markedly reduced lipid and protein oxidations, recruited the anti-oxidative defense system and promoted extracellular matrix degradation by modulating the levels of necrotic inflammation.

TL;DR: The findings suggest that berberine has potential applications as a therapeutic drug for diabetic nephropathy, and has significant research value, and the possible mechanisms have not been fully established.

TL;DR: Careful evaluation of prescription and non-prescription medications is crucial in the evaluation of the hypertensive individual and may obviate the need for expensive and unnecessary evaluations.

TL;DR: Developing an understanding of the mechanisms underlying the rapid antidepressant effects in treatment-resistant patients by drugs such as ketamine may uncover novel therapeutic targets that can be exploited to meet the Olympian challenge of developing faster, better and stronger antidepressant drugs.

TL;DR: It is concluded that thymol may exhibit promising anti-diabetic activity and protects C57BL/6J mice against HFD due to its anti- hyperglycaemic and anti-hyperlipidemic activity.

TL;DR: The beneficial therapeutic effects of inhibition of the RAS on the vasculature are discussed, as well as the need for additive effects on top of RAS inhibition.