Showing papers in "European Journal of Pharmacology in 2017"

TL;DR: The development of a model in which intra-plaque microvessels, haemorrhages, spontaneous atherosclerotic plaque ruptures, myocardial infarction and sudden death occur consistently is developed, which can be used as a validated model in pre-clinical studies to evaluate novel plaque-stabilizing drugs.

TL;DR: A comprehensive overview of the evidences supporting the hypothesis that PD could initiate in the gut is given and how food‐based therapies might then have an impact on PD pathology and/or improve non‐motor as well as motor symptoms in PD is considered.

TL;DR: The main sources of flavonoids, as well as their bioavailability and metabolism are summarized, and the available data about the anti‐aggregation effects of Flavonoids and the different mechanisms of action that has been proposed until now are discussed.

TL;DR: As knowledge of the complex roles individual MMPs play especially during the progression and rupture of atherosclerotic plaques expands, new impetus is required for clinical trials evaluating the therapeutic potential of selective MMP inhibition, which could limit cardiovascular morbidity and mortality worldwide.

TL;DR: There has been a desperate need arising since the past few decades for evolution of a drug that could treat the underlying causes of AD and halt its development in susceptible individuals.

TL;DR: New insights of atherosclerotic neovascularization are discussed, including the effects of leaky neovessels on intraplaque hemorrhage, both in experimental models and humans, and modalities for in vivo imaging and therapeutic interventions to target plaque angiogenesis are discussed.

TL;DR: Experimental evidence suggesting that sesamin could exert potent anti‐cancer activities in vitro and in vivo is compelling and can potentially be employed as an effective adjuvant therapeutic agent in ameliorating tumor development and progression, and therefore, it could be used in the prevention and/or treatment of various types of cancer.

TL;DR: EGCG protected against cardiac damage by decreasing apoptosis in myocardium tissue by maintaining the balance of anti‐apoptotic / pro‐APoptotic signaling proteins in the mitochondrial pathway of cell death, limiting oxidative stress while performing antioxidant and anti‐inflammatory effects, and protecting DNA integrity, sustaining cardiac health.

TL;DR: The results indicated that berberine significantly mitigated high glucose‐decreased cell viability, and nephrin and podocin expression as well as apoptosis in mouse podocytes, and may provide new insights into the molecular mechanisms underlying the anti‐diabetic nephropathy effect of berberines.

TL;DR: In obesity, combining therapies that reduce inflammation and increase combustion of lipids are most conceivable to restrain atherogenesis, and strategies that reduce the release of pro‐inflammatory factors and fatty acids from WAT and abdominal PVAT are probably most efficient.

TL;DR: It is suggested that SGLT2 inhibition disrupts the vicious cycle of obesity and inflammation, not only by promoting caloric loss, but also by suppression of obesity‐related inflammation in both the nervous system and skeletal muscle.

TL;DR: It is suggested that baicalin protected against hyperglycemia aggravated I/R injury by regulating mitochondrial functions in a manner dependent on AMPK.

TL;DR: These findings, together with a list of recent animal models of Alzheimer's Disease that appear feasible for the study of estrogen's CNS effect are here summarized and accompanied by the most recent data from clinical trials in which hormone therapy was initiated early after menopause.

TL;DR: Findings suggest that ozone’s antioxidant and anti-inflammatory effects might be partially associated with an induction of Nrf2 phosphorylation and activation, and pointed out ozone therapy as a potential therapeutic alternative for MS patients.

TL;DR: Chronic SAC treatment could ameliorate cognitive deficits in STZ‐diabetic rats through modulation of Nrf2/NF‐&kgr;B/TLR4/HO‐1, and acetylcholinesterase and attenuation of associated oxidative stress and neuroinflammation.

TL;DR: The results demonstrate that the combination of GLP‐1 and GIP receptor activation is superior to single GLp‐1 receptor activation alone, and new dual agonists may be a promising treatment for Parkinson's disease.

TL;DR: It is suggested thatTLR4 regulates VSMC calcification induced by Ox‐LDL through activation of NK‐&kgr;B, highlighting the critical role of TLR4/NK‐& kgr; B signaling in vascular calcification.

TL;DR: The role of autophagy in the cardioprotective effects of natural products such as resveratrol, berberine, and curcumin that are present in the authors' diet and should be taken into consideration for designing novel therapeutic agents is focused on.

TL;DR: The results revealed that CAR administration significantly protected the heart function, attenuated myocardial infarct size, increased SOD and CAT levels, reduced MDA level and especially decreased cardiomyocytes apoptosis, and the cardioprotective effects of CAR may be attributed to its antioxidant and antiapoptotic activities through activations of the MAPK/ERK and Akt/eNOS signaling pathways.

TL;DR: A new in‐vitro model for psoriasis using imiquimod induced differentiated HaCaT cells is developed which may be used for rapid screening of anti‐psoriatic drug candidates and warrant further mechanistic studies.

TL;DR: The anti‐oxidant, and anti‐inflammation properties of STS in preventing AS is mediated by its inhibition of CLIC1 expression and membrane translocation.

TL;DR: Naringenin is evaluated as anti-diabetic, anti-dyslipidemic anti-inflammatory and antineoplastic agent similar to metformin and its further development for therapeutic use in clinical practice is proposed.

TL;DR: Results indicate that cinnamaldehyde exists a potential protective effect against glutamate‐induced oxidative stress and apoptosis in PC12 cells.

TL;DR: It is desirable that a more comprehensive understanding of the functions of miRNAs‐regulated EMT will facilitate the development of novel diagnostic and therapeutic strategies for various debilitating organ fibrosis.

TL;DR: Applications of estrogenic terpenes and terpenoids are categorized into cancer treatment and prevention, cardioprotection, endocrine toxicity/reproductive dysfunction, food/supplement/traditional medicine, immunology/inflammation, menopausal syndromes and neuroprotection, where their benefits are discussed based on their availability, stability and variations.

TL;DR: The results suggest that the collagen coated nanofibrous scaffold with bioactive traditional medicine enhanced the faster healing of wound.

TL;DR: (‐)‐oleocanthal showed a potential beneficial effect in suppressing growth of hormone‐dependent breast cancer and improving sensitivity to tamoxifen treatment.

TL;DR: The role of miR‐214 in various cardiac disease conditions, including ischaemic heart diseases, cardiac hypertrophy, pulmonary arterial hypertension (PAH), angiogenesis following vascular injury and heart failure is discussed.

TL;DR: The results suggested that theaflavin‐3,3′‐digallate might be a potential therapeutic candidate for the treatment of inflammation and inflammatory diseases.

TL;DR: The data suggest that the activation of mTOR/I&kgr;B‐&agr;/NF‐&k gr;B pathway associated with vasodilator and proinflammatory mediator formation contributes to LPS‐induced hypotension and inflammation.