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Showing papers in "European Urology in 2019"


Journal ArticleDOI
TL;DR: The PI-RADS Steering Committee, using a consensus-based process, has recommended several modifications to PI- RADS v2, maintaining the framework of assigning scores to individual sequences and using these scores to derive an overall assessment category.

1,053 citations




Journal ArticleDOI
TL;DR: Smoking, obesity, hypertension, and hypertension are most strongly associated with RCC, and the cost effectiveness of a screening programme needs to be assessed on a country-specific level due to geographic heterogeneity in incidence and mortality rates, costs, and management implications.

745 citations



Journal ArticleDOI
TL;DR: The current RCT comparing ADT to ADT with EBRT to the prostate in patients with primary bone mPCa did not show a significant difference in overall survival, although the CI cannot exclude a substantial survival benefit.

348 citations


Journal ArticleDOI
TL;DR: The emergence of new drugs for mCRPC has improved treatment options dramatically and the best strategies for patient selection and optimal sequential use to achieve the longest cumulative survival improvement and to prevent early resistance remain unclear.

313 citations



Journal ArticleDOI
TL;DR: BCR has an impact on survival, but this effect appears to be limited to a subgroup of patients with specific clinical risk factors, which may form the basis of new BCR risk stratification (European Association of Urology BCR Risk Groups), which needs to be validated formally.

241 citations


Journal ArticleDOI
TL;DR: It is reported that the presence of prostate-specific membrane antigen (PSMA) is extremely variable both within one patient and between different patients, and this may limit the usefulness of PSMA scans and PSMA-targeted therapies.

217 citations


Journal ArticleDOI
TL;DR: This is the largest, most comprehensive examination of prostate cancer information on YouTube to date, including the first 150 videos on screening and treatment, used the validated DISCERN quality criteria for consumer health information and the Patient Education Materials Assessment Tool, and compared results for user engagement.

Journal ArticleDOI
TL;DR: It is found that a good treatment response could be achieved in a subgroup of patients with few side effects, and that treatment outcome was worse in patients with organ metastases and elevated lactate dehydrogenase in blood tests.

Journal ArticleDOI
TL;DR: BLCA can be stratified into six molecular subtypes with different overall survival (OS) and molecular features, and molecular subtyping is a promising way to tailor disease management for those who will benefit most.

Journal ArticleDOI
TL;DR: It is found that extended removal of lymph nodes did not reduce the rate of tumor recurrence in the expected range and a larger trial is required to determine whether extended compared with limited LND leads to a small, but clinically relevant, survival difference.

Journal ArticleDOI
TL;DR: The detection rates of (aggressive) prostate cancer among men with prior negative biopsies and a persistent suspicion of cancer using three different techniques of targeted biopsy based on magnetic resonance imaging were found to be no significant differences.

Journal ArticleDOI
TL;DR: Multiparametric magnetic resonance imaging (MRI) and MRI-directed biopsies using the Prostate Imaging-Reporting and Data System improves the detection of prostate cancers likely to cause harm, and at the same time decreases the Detection of disease that does not lead to harms if left untreated.

Journal ArticleDOI
TL;DR: As a new technique for surgical guidance, 99mTc-PSMA-RGS is feasible, and has been proved to be of high value for successful intraoperative detection and removal of metastatic lesions in PC patients scheduled for salvage surgery.




Journal ArticleDOI
TL;DR: OAB is seen as a complex, multifactorial symptom syndrome, resulting from multiple potential pathophysiological mechanisms, and there is a temptation to label OAB as "idiopathic" without obvious causation.

Journal ArticleDOI
TL;DR: Magnetic resonance imaging of the prostate before surgical removal for prostate cancer finds less than half of all individual prostate cancer tumors and less than two-thirds of clinically significant CaP foci.

Journal ArticleDOI
TL;DR: The treatment landscape for mccRCC has evolved since the introduction of VEGF inhibitors and combination therapies involving checkpoint inhibitors could be the next standard of care.

Journal ArticleDOI
TL;DR: It is found that different areas from the same tumor are often molecularly different, particularly in the basal-squamous subtype, and this biological diversity must be taken into account when interpreting clinical molecular tests performed on bladder cancer samples.

Journal ArticleDOI
TL;DR: Deleterious TSG variants are associated with an increased risk of relapse (L) and death (M1) in CSPC and these findings help identify patients with aggressive features who may benefit from intensified treatment.

Journal ArticleDOI
Elizabeth Page, Elizabeth Bancroft, Mark N. Brook, Melissa Assel1  +147 moreInstitutions (65)
TL;DR: After 3 yr of prostate-specific antigen (PSA) testing, it is demonstrated that after 3’yr of screening, more serious prostate cancers are detected in men with BRCA2 mutations than in those without these mutations.


Journal ArticleDOI
TL;DR: Mutation status of BRCA1/2 and ATM is associated with GR among men undergoing active surveillance, and men on active surveillance with inherited mutations in BRCa1/1 and ATM are more likely to harbor aggressive prostate cancer.


Journal ArticleDOI
Thomas B. Lam1, Thomas B. Lam2, Steven MacLennan1, Peter Paul M. Willemse3, Malcolm David Mason4, Karin Plass, Robert Shepherd, Ruud Baanders, Chris H. Bangma5, Anders Bjartell6, Alberto Bossi7, Erik Briers, Alberto Briganti8, Karel Tim Buddingh, James W.F. Catto9, James W.F. Catto10, Maurizio Colecchia, Brett Cox, Marcus G. Cumberbatch9, Jeff Davies, Niall F. Davis11, Maria De Santis12, Paolo Dell'Oglio8, André Deschamps, James Donaldson2, James Donaldson1, Shin Egawa13, Christian D. Fankhauser14, Stefano Fanti15, Nicola Fossati8, Giorgio Gandaglia8, Silke Gillessen16, Silke Gillessen17, Nikolaos Grivas18, Tobias Gross19, Jeremy Grummet20, Ann Henry21, Alexandre Ingels, Jacques Irani, Michael Lardas, Matthew Liew22, Daniel W. Lin23, Daniel W. Lin24, Lisa Moris25, Muhammad Imran Omar1, Karl H. Pang9, Catherine Paterson26, Catherine Paterson27, Catherine Paterson1, Raphaële Renard-Penna28, Maria J. Ribal29, Monique J. Roobol5, Morgan Rouprêt28, Olivier Rouvière30, Gemma Sancho Pardo, Jonathan Richenberg31, Ivo G. Schoots32, J.P. Michiel Sedelaar33, Phillip D. Stricker34, Derya Tilki, Susanne Vahr Lauridsen35, Roderick C.N. van den Bergh, Thomas Van den Broeck25, Theodorus H. van der Kwast32, Henk G. van der Poel18, Geert J.L.H. van Leenders32, Murali Varma36, Philippe D. Violette37, Christopher J.D. Wallis38, Christopher J.D. Wallis39, Thomas Wiegel, Karen Wilkinson40, Fabio Zattoni, James N'Dow2, James N'Dow1, Hendrik Van Poppel25, Philip Cornford, Nicolas Mottet 
TL;DR: Consensus statements and the findings are expected to guide and inform routine clinical practice and research, until higher levels of evidence emerge through prospective comparative studies and clinical trials.