Showing papers in "Experimental Hematology in 2005"

TL;DR: The results have provided a foundation for a more reproducible and reliable quality control using genotypic analysis for defining MSC.

TL;DR: Research in this field has an impact on understanding regulatory mechanisms in general and is of particular importance for eventual development of molecular cures for sickle cell disease and beta thalassemia.

TL;DR: It is found that CD14+ monocytes from blood activate MSCs to secrete inhibitory molecules that lead to inhibition of alloreactive T cells, which represents a unique immune regulatory paradigm that can potentially be exploited in clinic.

TL;DR: This review will discuss some of the principle studies that led to two widely accepted definitions of blood islands and will examine more recent studies performed in murine embryos to determine whether either of these popular definitions can be directly applied.

TL;DR: The data show that in ET and PV patients PMN activation plays an important role in increasing circulating PMN-platelet aggregates and suggest that aspirin treatment may decrease their formation.

TL;DR: SB 394725, a small molecule with a molecular weight of 452 Da, is capable of activating Tpo-specific signal transduction, proliferation, and differentiation responses similar to the responses and functions of the protein growth factor, Tpo.

TL;DR: G-CSF treatment significantly improved survival and liver histology in chemically injured mice, predominantly by promoting endogenous repair mechanisms and might offer a novel therapeutic approach for the treatment of acute and chronic liver diseases in humans.

TL;DR: USSC produce functionally significant amounts of hematopoiesis-supporting cytokines and are superior to BMMSC in expansion of CD34+ cells from CB and are therefore a suitable candidate for stroma-driven ex vivo expansion of heMatopoietic CB cells for short-term reconstitution.

TL;DR: Recent findings support a model of hematopoietic ontogeny in which the conceptus' first maturing blood cells and committed progenitors are provided by the yolk sac, allowing survival until AGM-derived hematopolietic stem cells can emerge, seed the liver and differentiate into mature blood cells.

TL;DR: Administration of antiapoptotic cytokine combinations such as stem cell factor, Flt-3 ligand, thrombopoietin, and interleukin-3 (4F), may be important for multilineage recovery, particularly when these factors are administered early.

TL;DR: Investigating the in vitro antiproliferative activities of the HDACIs, suberoylanilide hydroxamic acid (SAHA), and valproic acid against 14 human lymphoid cancer cell lines found them to be promising therapeutic agents for human lymphoids cancers.

TL;DR: The current understanding of how bone morphogenic protein, transforming growth factor-beta, Wnt, and fibroblast growth factor pathways influence germ layer induction in both the embryo and in the ES cell differentiation system is addressed.

TL;DR: Normal myeloid development and acute leukemia are now understood to represent opposite sides of the same hematopoietic coin.

TL;DR: Macrophage inflammatory protein-1α, an osteoclast stimulatory factor produced by primary multiple myeloma cells, increases bone destruction and tumor burden in murine models of MM and utilizing either CCR1 or CCR5 for its effects on OCL formation and myelomas cells is demonstrated.

TL;DR: FH-B-hTERT can induce hESCs differentiation into hematopoietic cells more efficiently than S17 and will be useful for studying the regulation of globin gene expression during early human hematoiesis.

TL;DR: It is suggested that the placenta provides a supportive niche where the definitive hematopoietic stem cell pool can be temporarily established during development, and the stem cell-promoting properties of the placental niche can be harnessed in vitro to support HSC formation, maturation, and/or expansion in culture.

TL;DR: Even though HSC have been found to differentiate into a variety of nonhematological cell types, they usually do not differentiate into mesenchymal stem cells after allogeneic transplantation.

TL;DR: An overview of the data obtained from the mouse and avian models on the cellular origins of the hematopoietic system is given.

TL;DR: Data indicate that Sca-1 plays a role in hematopoietic progenitor/stem cell lineage fate and c-kit expression, and affects human as well as mouse stem/progenitor cell activity, suggesting the possibility of a functional human ScA-1 homologue.

TL;DR: A means of identifying subsets containing all the CFU-F and sufficiently enriched to detect them in fresh BM, enabling evaluation of mesenchymal content of BM collections for cell therapy.

TL;DR: The ability of MSC to downregulate T-cell priming, proliferation, and cytokine release is deficient in patients with SAA, persists indefinitely after immunosuppressive therapy, but seems to be restored after BMT.

TL;DR: Results indicate that adult hu-ST in the presence of appropriate cytokines can be used to efficiently expand/maintain myeloid and lymphoid cell populations from human BM and CB HSC.

TL;DR: A new role for platelets in host defense is established and reexamination of their active function in microbicidal and other host defense activities is suggested.

TL;DR: It is suggested that sustained administration of TGF-beta1 may be more effective in suppressing terminal differentiation than intermittent dosing and thus effective for cartilage repair.

TL;DR: Examination of GFP+ vs GFP- populations shows that differentiation, but not commitment, to the myeloid lineage requires PU.1.1, suggesting that PU.

TL;DR: It is proposed that decreased internalization of WHIM-associated mutated CXCR4 leads to prolongation/enhancement of signaling in response to SDF1 and that this may provide the biochemical basis for the autosomal dominant abnormalities of cell trafficking and function associated with WHIM syndrome.

TL;DR: Data is provided from others and the laboratory that supports the concept that BM-derived stem cells are heterogeneous, and the presence of TCSC/PSC in BM tissue should be considered before experimental evidence is interpreted as trans-dedifferentiation/plasticity of HSC.

TL;DR: The results indicate that the Raf/MEK/ERK and PI3K/AKT signaling pathways play critical roles in the differentiation and survival of immature MoDCs and demonstrates that activated p38 is detrimental to the differentiation of immatureMoDCs.

TL;DR: KHYG-1 is a valuable model for the study of enhanced cytotoxicity by NK cells and in addition to the activation of NKp44, KHYg-1 may induce apoptosis of tumor cells by the newly described granzyme M/perforin pathway.

TL;DR: It is indicated that CTCE-0021 is an efficient and rapid mobilizer of PMN and HPC when used alone and shows synergistic activity when used in combination with G-CSF.