Journal•ISSN: 1747-6348
Expert Review of Respiratory Medicine
Taylor & Francis
About: Expert Review of Respiratory Medicine is an academic journal published by Taylor & Francis. The journal publishes majorly in the area(s): COPD & Medicine. It has an ISSN identifier of 1747-6348. Over the lifetime, 1511 publications have been published receiving 25328 citations. The journal is also known as: Respiratory medicine.
Topics: COPD, Medicine, Asthma, Lung cancer, Population
Papers published on a yearly basis
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TL;DR: This review summarizes the recent literature on the epidemiology of adult obstructive sleep apnea from various population-based studies and focuses on the economic healthcare burden of OSA and the importance of recognizing the largely undiagnosed OSA population.
Abstract: This review summarizes the recent literature on the epidemiology of adult obstructive sleep apnea (OSA) from various population-based studies. Despite methodologic differences, comparisons have yielded similar prevalence rates of the OSA syndrome in various geographic regions and across a number of ethnic groups. Risk factors for OSA including obesity, aging, gender, menopause and ethnicity, are analyzed. We also provide discussion on adverse medical conditions associated with OSA, including hypertension, stroke, coronary artery disease, congestive heart failure, cardiovascular mortality, insulin resistance and neurocognitive dysfunction. Finally, with the progression of the global obesity epidemic, we focus on the economic healthcare burden of OSA and the importance of recognizing the largely undiagnosed OSA population, with an emphasis on strategies to improve access to diagnostic resources.
434 citations
TL;DR: This article reviews the literature addressing the relationship between obesity and lung function, and studies addressing how the mechanical and inflammatory effects of obesity might lead to changes in lung mechanics and pulmonary function in obese adults and children.
Abstract: Introduction: There is a major epidemic of obesity, and many obese patients suffer with respiratory symptoms and disease. The overall impact of obesity on lung function is multifactorial, r...
382 citations
TL;DR: In this paper, the authors review and synthesize published reports of the lung microbiota of healthy and diseased subjects, discuss trends of microbial diversity and constitution across disease states, and look to the extrapulmonary microbiome for hypotheses and future directions for study.
Abstract: Novel culture-independent techniques have recently demonstrated that the lower respiratory tract, historically considered sterile in health, contains diverse communities of microbes: the lung microbiome. Increasing evidence supports the concept that a distinct microbiota of the lower respiratory tract is present both in health and in various respiratory diseases, although the biological and clinical significance of these findings remains undetermined. In this article, the authors review and synthesize published reports of the lung microbiota of healthy and diseased subjects, discuss trends of microbial diversity and constitution across disease states, and look to the extrapulmonary microbiome for hypotheses and future directions for study.
329 citations
TL;DR: The goal of this article is to summarize and evaluate the results of experimental findings in LPS-induced ALI/ARDS, and the possible mechanisms and treatments elucidated, and disadvantages of such models in pulmonary research and new directions for future investigations are discussed.
Abstract: Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a syndrome characterized by pulmonary edema and acute inflammation. Lipopolysaccharide (LPS), a major component in Gram-negative bacteria, has been used to induce ALI/ARDS. LPS-induced animal models highlight ways to explore mechanisms of multiple diseases and provide useful information on the discovery of novel biomarkers and drug targets. However, each model has its own merits and drawbacks. The goal of this article is to summarize and evaluate the results of experimental findings in LPS-induced ALI/ARDS, and the possible mechanisms and treatments elucidated. Advantages and disadvantages of such models in pulmonary research and new directions for future investigations are also discussed.
282 citations
TL;DR: The most frequently reported asthma comorbid conditions include rhinitis, sinusitis, gastroesophageal reflux disease, obstructive sleep apnea, hormonal disorders and psychopathologies, which may share a common pathophysiological mechanism with asthma.
Abstract: Asthma is often associated with various comorbidities. The most frequently reported asthma comorbid conditions include rhinitis, sinusitis, gastroesophageal reflux disease, obstructive sleep apnea, hormonal disorders and psychopathologies. These conditions may, first: share a common pathophysiological mechanism with asthma; second: influence asthma control, its phenotype and response to treatment; and third: be more prevalent in asthmatic patients but without obvious influence on this disease. For many of these, how they interact with asthma remains to be further documented, particularly for severe asthma. If considered relevant, they should, however, be treated appropriately. Further research is needed on the relationships between these conditions and asthma.
218 citations