Showing papers in "FEBS Letters in 1998"

TL;DR: The expression pattern of mRNA encoding two orexin receptors (OX1R and OX2R) in the rat brain was examined and the presence of orexIn receptor mRNA in the hypothalamus is in support of its proposed role in feeding regulation.

TL;DR: The enzymatic activity of the cell‐free extracts exhibits similar properties to the cytosolic broad‐specificity β‐glucosidase previously described in mammals.

TL;DR: It is shown that the recording of reversible absorbance changes at 295 nm allows to precisely monitor intramolecular guanine (G)‐quartet formation and dissociation.

TL;DR: Results suggest that TIMP‐3, unlike the other TIMPs, may be important in the modulation of pathological events in which TNF‐α secretion is involved.

TL;DR: The antioxidant capacities of quercetin, 3′‐O‐Methylquercet in and some of their conjugated derivatives were compared by the measurement of the conjugate dienes resulting from the Cu2+‐induced oxidation of human LDL.

TL;DR: Results indicate that IRF‐7 is a key factor in the positive feedback regulation of IFN‐β/β production, and in cells lacking p48, an essential component ofIFN stimulated gene factor 3 (ISGF3).

TL;DR: Using a recently developed adenovirus that overexpresses the inhibitory subunit, IκBα, it is demonstrated that an absolute requirement for NF‐κB in upregulation of MMP‐9 is necessary but not sufficient for synergistic upregulation.

TL;DR: The role of cytochrome c in apoptosis may be understood within the framework of the concept assuming that the evolutionary primary function of apoptosis was to purify tissues from ROS‐overproducing cells and the pro‐apoptosis activity might represent one of the anti‐oxidant functions inherent in this cy tochrome.

TL;DR: It is reported here that the G272V, P301L, V337M and R406W mutations lead to a marked reduction in the ability of tau to promote microtubule assembly, suggesting partial loss‐of‐function may be the primary effect of the known missense mutations in tau.

TL;DR: These enzymic reactions provide a mechanism for generation of NO under hypoxic conditions where nitric oxide synthase does not function, suggesting a vasodilatory role in ischaemia.

TL;DR: It is reported that the mtDNA sequence of the strain used for nuclear genome sequencing assembles into a circular map of 85 779 bp which includes 10 kb of new sequence, and a list of seven small hypothetical open reading frames (ORFs) is given.

TL;DR: It is reported here that C‐terminally truncated recombinant α‐synuclein readily assembles into filaments resembling those isolated from diseased brain and suggest that truncation by proteolysis may play a role in the pathological process.

TL;DR: The L45 loop regions in type I receptors are identified as critical determinants in specifying Smad isoform activation in transcriptional responses.

TL;DR: Diaminofluoresceins (DAFs), new fluorescence indicators for NO, were applied to detect the release of NO from bovine aortic endothelial cells (ECs) and could detect the generation of NO not only from inducible NO synthase expressed in macrophages, but also from constitutive NO synthases expressed in ECs.

TL;DR: It is found that co‐expression with caveolin 1 dramatically inhibits signaling from EGF‐R, Raf, MEK‐1 and ERK‐2 to the nucleus and suggests that a novel form of reciprocal negative regulation exists between p42/44 MAP kinase activation and caveolin‐1 protein expression.

TL;DR: It is shown that Resveratrol is a remarkable inhibitor of ribonucleotide reductase and DNA synthesis in mammalian cells, which might have further applications as an antiproliferative or a cancer chemopreventive agent in humans.

TL;DR: This minireview focuses on the acquisition of elasticity data of biomaterials by AFM, and a possible theoretical model is presented, followed by a practical `how to do it with AFM' guide.

TL;DR: In this article, the effects of these molecular polymorphisms on the ability of HDL to protect LDL from oxidative modification were examined, and it was shown that HDL from QQ/MM homozygotes was most effective at protecting LDL while HDL from RR/LL homozygote was least effective.

TL;DR: It is reported that aggregates of NAC and α‐syn proteins induced apoptotic cell death in human neuroblastoma SH‐SY5Y cells, indicating that accumulation of α‐ Synuclein and its degradation products may play a major role in the development of the pathogenesis of these neurodegenerative diseases.

TL;DR: The absorption analysis using rat everted small intestine demonstrated that luteolin was converted to glucuronides during passing through the intestinal mucosa and thatluteolin 7‐O‐β‐glucoside was absorbed after hydrolysis to luteolini.

TL;DR: E ectopic expression of TRUNDD attenuated TRAIL‐induced apoptosis in mammalian cells and was detected in multiple human tissues, indicating an inhibitory role.

TL;DR: It is demonstrated that NLT (novel liver‐specific transport protein) is a multispecific organic anion transporter of the liver, and the amino acid sequence of NLT shows 42% identity to that of the renal multisPEcific organicAnion transporter, OAT1.

TL;DR: Mixtures of carotenoids were more effective than the single compounds and this synergistic effect was most pronounced when lycopene or lutein was present.

TL;DR: The results suggest that anandamide and 2‐arachidonoylglycerol can be inactivated by the same enzyme.

TL;DR: In situ hybridization study revealed that fractalkine mRNA was dominantly expressed in neuronal cells particularly in the olfactory bulb, cerebral cortex, hippocampus, caudate putamen and nucleus accumbens and in glial cells throughout the whole brain.

TL;DR: A scheme is proposed for designating enzymes that hydrolyse the polysaccharides in the cell walls of plants, predominantly β‐1,4‐glycanases, based on the classification of the catalytic domains of glycoside hydrolases into families of related amino acid sequences.

TL;DR: The structure of a novel human PPARγ subtype,PPARγ3, is described, which is activated by thiazolidinediones and prostaglandin J derivatives and binds with high affinity to a PPRE.

TL;DR: All newly described activities of cathepsin B, namely processing of caspase zymogens and induction of nuclear apoptosis, are inhibited by the synthetic peptide casp enzyme inhibitors z‐VAD.fmk, z‐DEVD.fMK and to a lesser extent by Ac‐YVAD .cmk.

TL;DR: The phosphorylation site in eIF2Bϵ is identified as Ser540 and it is shown that treatment of eif2B with GSK‐3 inhibits its activity and seems likely to be important in the overall activation of translation by this hormone.

TL;DR: These findings clarify the mechanisms through which irreversible permeability Transition occurs with subsequent large amplitude swelling culminating in the release of intermembrane proteins from mitochondria and confirm the hypothesis formulated by Skulachev linking permeability transition to activation of the apoptogenic catabolic enzymes.