Showing papers in "FEBS Letters in 2001"

TL;DR: Data is reviewed indicating that MPT is not a consequence of the opening of a pre‐formed pore, but the consequence of oxidative damage to pre‐existing membrane proteins.

TL;DR: This review summarises current knowledge on the molecular mechanisms and components of neutrophil apoptosis.

TL;DR: Recent advances in understanding the molecular pathways which govern the decision of mammalian somatic cells to enter S phase are highlighted, and the so‐called cell cycle checkpoints which guard the G1/S transition and S phase progression against potentially deleterious effects of genotoxic stress are highlighted.

TL;DR: The data indicate that the in vitro ES differentiation system has a potential to generate mature hepatocytes and has also been found useful in analyzing the role of growth factors and intracellular signaling molecules in hepatic development.

TL;DR: It is suggested that Ultraviolet‐B exposure leads to the generation of ROS, from multiple sources, and NO, through increased NOS activity, giving rise to parallel signaling pathways mediating responses of specific genes to UV‐B radiation.

TL;DR: Sequence and structure comparisons now suggest that many of the TIM‐barrel enzymes are evolutionarily related.

TL;DR: These HDC‐deficient mice are viable and fertile but exhibit a decrease in the numbers of mast cells while the remaining mast cells show an altered morphology and reduced granular content.

TL;DR: ‘management’ of the energy pool (especially ATP) seems to constitute an ethanol stress response and to involve different mechanisms.

TL;DR: It is found that in vitro, unmodified α‐synuclein can be directly degraded by the 20S proteasome, suggesting an ubiquitin‐independent mechanism of proteasomal degradation for α‐ synuclein and other natively unfolded proteins.

TL;DR: Investigation of magainin II amide analogs with cationic charges showed that enhancement of the peptide charge up to a threshold value of +5 and conservation of appropriate hydrophobic properties optimized the antimicrobial activity and selectivity.

TL;DR: A method to quantitate the relative contributions of metabolic and hierarchical regulation is developed and it is concluded that the glycolytic flux in three species of parasitic protists is rarely regulated by gene expression alone.

TL;DR: How ROS are generated and how they affect mitochondrial function in GNT are reported and the relationship between ROS generation and cytochrome c release is described in detail, with the released cy tochrome c playing a role in the cell defense mechanism against neurotoxicity.

TL;DR: Data show that TBB is a quite selective inhibitor of CK2, that can be used in cell‐based assays and also inhibits endogenous CK2 in cultured Jurkat cells.

TL;DR: Improved anion sensitivities with K d down to 2 mM for I−, 40 mM for Cl−, and 10 mM for NO3 − were revealed and their utility in cells was demonstrated using transfected cells expressing the cystic fibrosis transmembrane conductance regulator chloride channel.

TL;DR: It is proposed that the relatively hydrophobic pesticides preferentially bind to a partially folded intermediate conformation of α‐synuclein, accounting for the observed conformational changes, and leading to association and subsequent fibrillation, which suggest one possible underlying molecular basis for Parkinson's disease.

TL;DR: Using the ErbB family of receptor tyrosine kinases, the diversity of the down regulation process is exemplified, and two sorting steps whose molecular details are emerging are concentrated on.

TL;DR: This compound was purified from E. coli ΔlytB mutants by preparative anion exchange chromatography, and identified by mass spectrometry, 1H, 13C and 31P NMR spectroscopy, and NOESY analysis as (E)‐4‐hydroxy‐3‐methyl‐but‐2‐enyl pyrophosphate (HMB‐PP).

TL;DR: This paper showed that correction of protein misfolding constitutes a viable therapeutic strategy for protein conformational diseases, including several neurodegenerative diseases and systemic amyloidosis, which are thought to arise from protein aggregation.

TL;DR: The results provide the first demonstration of direct genetic evidence that the antimicrobial activity of lysozyme is operationally independent of its muramidase activity, and strongly suggest the antimacterial action of ly sozyme is due to structural factors.

TL;DR: In this article, an identical single amino acid substitution converted novel chromoproteins from the species Anthozoa (Heteractis crispa, Condylactis gigantea, and Goniopora tenuidens) into far-red fluorescent proteins (FPs) (emission lambda(max)=615-640 nm).

TL;DR: It is demonstrated that plant NRT2 proteins do have a role in HATS, and the de‐regulated expression of a Nicotiana plumbaginifolia Nrt2 gene restored the mutant nitrate influx to that of the wild‐type.

TL;DR: This work has investigated the role of Complex I in superoxide radical production in bovine heart submitochondrial particles and found that the one‐electron donor in the Complex to oxygen is a redox center located prior to the binding sites of three different types of CoQ antagonists, to be identified with a Fe–S cluster.

TL;DR: The results suggest that an unbalance between angiogenic stimulators and inhibitors may contribute to retinal neovascularization.

TL;DR: The stress hormone methyljasmonate strongly induced G10h gene expression coordinately with other terpenoid indole alkaloid biosynthesis genes in a C. roseus cell culture, and degenerate PCR primers based on amino acid sequence information cloned the corresponding cDNA.

TL;DR: The zinc metallo‐hydrolase family of the β‐lactamase fold has grown quite rapidly, accompanied by the accumulation of sequence and structure data, and the functional and structural varieties of the growing protein family are described.

TL;DR: It is proposed that regulation of DCT1/DMT1 mRNA by iron involves post‐transcriptional regulation through the binding of IRP1 to the transporter's IRE, as well as other as yet unknown factors.

TL;DR: The results suggest that adiponectin gene expression is severely suppressed by β‐adrenergic agents via activation of a GS‐protein–PKA‐dependent pathway, and support a possible role of adip onectin in catecholamine‐induced insulin resistance.

TL;DR: An overview of recent findings, the potential importance of PKB in the regulation of glucose transport and metabolism, and comment on future directions are provided.

TL;DR: Atomic force microscopy is used to study supported lipid bilayers, consisting of a fluid phosphatidylcholine, sphingomyelin and cholesterol, and the presence of cholesterol was found to induce bilayer coupling.

TL;DR: It is shown here that nucleophosmin/B23 functions as a histone chaperone protein such as nucleoplasmin, TAF‐I, and NAP‐I as a stimulatory factor for replication from the adenovirus chromatin.