Showing papers in "Fertility and Sterility in 2004"

TL;DR: Since the 1990 NIH-sponsored conference on polycystic ovary syndrome, it has become appreciated that the syndrome encompasses a broader spectrum of signs and symptoms of ovarian dysfunction than those defined by the original diagnostic criteria.

TL;DR: There is accumulating evidence that workplace exposure to toxic substances contributes to male infertility, and men suffering from infertility problems may do well to look at their occupations, where exposure to certain substances may be a contributory factor.

TL;DR: High or low BMI was associated with reduced semen quality, and it remains to be seen whether the increasing occurrence of obesity in the Western world may contribute to an epidemic of poor semen quality registered in some of the same countries.

TL;DR: The relationship between HDS and poor IVF fertilization rates provides preliminary evidence that ICSI may be indicated in men with > or =15% HDS, and men with high levels of DNA fragmentation were at greater risk for low blastocyst rates and failure to initiate an ongoing pregnancy.

TL;DR: Single blastocyst transfer is an effective method of eliminating multiple births while maintaining high pregnancy rates in this selected group of patients.

TL;DR: Laroscopic excision of endometriosis is more effective than placebo at reducing pain and improving quality of life, and surgery is associated with a 30% placebo response rate that is not dependent on severity of disease.

TL;DR: The extent of nuclear DNA fragmentation in prepared ejaculated spermatozoa used in IVF negatively correlates with blastocyst development.

TL;DR: The data clearly demonstrate that DNA fragmentation, as determined by the TUNEL assay, is predictive for pregnancy in IVF, which implies that spermatozoa with DNA fragmentation can still fertilize an oocyte but that when paternal genes are "switched on," further embryonic development stops, resulting in failed pregnancy.

TL;DR: Lifestyle has a significant and cumulative impact on fecundity; dose-dependent effects occur with smoking, alcohol, and tea/coffee consumption and Appropriate counseling could result in substantial reductions in the referrals for fertility investigations and treatments.

TL;DR: An unexpectedly high percentage of couples who performed IVF discontinued the treatment before the three cycles that were offered to a majority of the couples, mainly due to psychological stress.

TL;DR: These data demonstrate a strong association between day 3 serum AMH/MIS level and IVF outcome in women younger than 42 years of age and may offer greater prognostic value than other currently available serum markers of ART outcome.

TL;DR: It is suggested that insulin-sensitizing drugs increase ovulatory frequency and ameliorate hyperandrogenemia, even in nonobese women with PCOS who appear to have normal insulin sensitivity.

TL;DR: Out-of-phase biopsy results poorly discriminated between women from fertile and infertile couples in either the midluteal or late luteal phase and should not be used in the routine evaluation of infertility.

TL;DR: The standard semen analysis to assess sperm motility, sperm morphology, and the SDI scores is a useful tool in identifying infertile men with high seminal ROS in infertility clinics where facilities for measuring levels of seminal ROS are not available.

TL;DR: Histologic endometrial dating does not have the accuracy or the precision necessary to provide a valid method for the diagnosis of luteal phase deficiency or to otherwise guide the clinical management of women with reproductive failure.

TL;DR: Insulin resistance was detected in approximately 80% of women with PCOS, and in 95% of obese women, and the detection of IR is superior using the calculated indices HOMA and QUICKI.

TL;DR: Long-term treatment (up to 5 years) with soy phytoestrogens was associated with an increased occurrence of endometrial hyperplasia, calling into question the long-term safety of phy toestrogens with regard to the endometrium.

TL;DR: Key methodologic issues for a large-scale, randomized trial of lifestyle intervention in PCOS include minimizing early dropout from the lifestyle intervention and including a range of body mass index that is not skewed toward severe obesity.

TL;DR: Laroscopic cystectomy of endometriomas is a better choice than fenestration and coagulation because the former technique leads to a lower recurrence of signs and symptoms and a lower rate of reoperation and a higher cumulative pregnancy rate than the latter.

TL;DR: Combined treatment with l-carnitine and l-acetyl-c Carnitine in a controlled study of efficacy was effective in increasing sperm motility, especially in groups with lower baseline levels.

TL;DR: Those who completed the short-term hypocaloric diet had a significant weight loss and a significant improvement in their reproductive and metabolic abnormalities, and there was no increased benefit to a high-protein diet.

TL;DR: Both LPO and TAC levels were positively correlated with the pregnancy rate, suggesting Lipid peroxidation may be a good marker of metabolic activity within the follicle, and some amounts may be necessary to establish a pregnancy.

TL;DR: The safety and efficacy of vaginal administration have been well established and the vaginal route of drug delivery is acceptable and may even be a preferable route of administration for many drugs, particularly hormones, whether for contraception or postmenopausal estrogen therapy.

TL;DR: Children who are born after intracytoplasmic sperm injection have an increased risk of a major congenital malformation compared with those born after spontaneous conception, mainly due to paternal and maternal risk factors.

TL;DR: The combination of letrozole and norethindrone acetate achieved marked reduction of laparoscopically visible and histologically confirmed endometriosis in all 10 patients and significant pain relief in nine out of 10 patients who had not responded previously to currently available treatments.

TL;DR: High day 1 ROS levels in culture media were associated with lower pregnancy rates in both IVF and ICSI cycles and may be an important biochemical marker for early embryonic growth.

TL;DR: Determination of ovarian cancer risk should take into account the type of infertility (primary vs. secondary) and underlying causes, and further study of endometriosis may provide insights into ovarian carcinogenesis.

TL;DR: The endometrial cavity is frequently invaded by microorganisms, and subclinical endometricrial infection or inflammation may play a role in implantation failure after IVF, spontaneous abortion, and preterm birth.

TL;DR: Preimplantation genetic diagnosis is evolving to become a clinical option for couples at risk for producing offspring with Mendelian diseases, has a positive numerical impact in standard assisted reproduction practices through aneuploidy testing, and reduces by at least fourfold the spontaneous abortion rate in couples carrying translocations.

TL;DR: Patients having subserosal or intramural leiomyomas of <4 cm not encroaching on the uterine cavity have IVF-ICSI outcomes comparable to those of patients without such leoomyomas, therefore, they might not require myomectomy before being scheduled for assisted reproduction cycles.