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Showing papers in "Fertility and Sterility in 2012"



Journal ArticleDOI
TL;DR: Application of the STRAW + 10 staging system should improve comparability of studies of midlife women and facilitate clinical decision making and provide a more comprehensive basis for assessing reproductive aging in research and clinical contexts.

1,157 citations


Journal ArticleDOI
TL;DR: The disease process is reviewed from theories regarding origin to the molecular basis for disease sequelae and a thorough understanding of the histopathogenesis and pathophysiology of endometriosis is essential to the development of novel diagnostic and treatment approaches for this debilitating condition.

1,066 citations


Journal ArticleDOI
TL;DR: Although fresh ET is the norm in IVF, results of this systematic review of observational studies suggest that pregnancies arising from the transfer of frozen thawed IVF embryos seem to have better obstetric and perinatal outcomes.

433 citations


Journal ArticleDOI
TL;DR: Deep endometriosis, defined as adenomyosis externa, is a rarely a progressive and recurrent disease, while bowel resection should be avoided, except for the sigmoid.

353 citations


Journal ArticleDOI
TL;DR: LARC methods (primarily IUDs) are contributing to an increase in contraceptive effectiveness in the United States and among women at risk of unintended pregnancy, increases in LARC use more than offset decreases in sterilization.

335 citations


Journal ArticleDOI
TL;DR: Evidence deriving from the evaluation of serum AMH level modifications after surgical excision of endometriomas supports a surgery-related damage to ovarian reserve.

307 citations


Journal ArticleDOI
TL;DR: Children conceived by IVF and/or ICSI are at significantly increased risk for birth defects, and there is no risk difference between children conceived byIVF and-or I CSI.

299 citations


Journal ArticleDOI
TL;DR: These nonselection data provide the first prospective, blinded, clinical study directly measuring the predictive value of aneuploidy screening for clinical outcome, whereas implantation and delivery rates of euploid embryos are increased relative to the entire cohort of transferred embryos.

297 citations


Journal ArticleDOI
TL;DR: Analysis of retrospective data indicated that culturing and selecting embryos by TMS significantly improved the relative probability of clinical pregnancy and was attributed to a combination of stable culture conditions and the use of morphokinetic parameters for embryo selection.

277 citations


Journal ArticleDOI
TL;DR: This protocol would minimize delays and allow more patients to undergo fertility preservation and still proceed with cancer treatment within 2-3 weeks, as well as be as effective as conventional-start COS in fertility preservation.

Journal ArticleDOI
TL;DR: Embryos with DC2-3 had a statistically significantly lower implantation rate than embryos with a normal cleavage pattern, suggesting that rejection of these embryos for transfer could improve the implantation rates.

Journal ArticleDOI
TL;DR: The study does not show negative results for elevated P levels on oocyte performance in terms of fertilization, cleavage rate, or PR of FET cycles within different ovarian responses, offering no evidence for a detrimental effect of high P on oocytes quality.

Journal ArticleDOI
TL;DR: Current studies examining the evidence for low grade inflammation in PCOS are small, heterogeneous for the diagnosis, confounded by degree of adiposity and do not consistently demonstrate a clinically relevant increase in the above mentioned biomarkers.

Journal ArticleDOI
TL;DR: The sperm epigenome implies a poising of the paternal genome for embryogenesis and a possible role in the establishment of totipotency of the embryo and may help in understanding some causes of reduced fertility and transmission of disease risk.

Journal ArticleDOI
TL;DR: EPE(2) level (>3,450 pg/mL) on the day of hCG administration during COH is associated with greater odds of developing PreE and delivery of an SGA infant in singleton pregnancies resulting from IVF cycles.

Journal ArticleDOI
TL;DR: The authors discuss factors that are associated with RIF and address various treatment options.

Journal ArticleDOI
TL;DR: These data demonstrate the first qPCR technology capable of accurate aneuploidy screening of all 24 chromosomes in 4 hours, and provide an opportunity to evaluate trophectoderm biopsies with subsequent fresh euploid blastocyst transfer.

Journal ArticleDOI
TL;DR: The factors which might cause defective endometrial receptivity are reviewed, including uterine polyps, septa, leiomyomata and adhesions, which are the key to increasing pregnancy rates in IVF.

Journal ArticleDOI
TL;DR: Highly successful cryopreservation of all embryo developmental stages is possible with the use of the Cryotop system and there are no variables clearly exerting a negative effect on the survival and delivery rates.

Journal ArticleDOI
TL;DR: Overnight transportation of ovarian tissue appears to be possible in combination with appropriate transportation logistics, however, further investigations are needed before this procedure can be offered as a chance for women to preserve fertility independently of direct access to a tissue-processing bank.

Journal ArticleDOI
TL;DR: Results suggest measures of ovarian reserve are impaired in a dose-dependent manner among cancer survivors compared with unexposed females of similar age and the predictive value of measures for pregnancy and menopause must be studied.

Journal ArticleDOI
TL;DR: This is the first study to evaluate the direct impact of laptop use on human spermatozoa and it is speculated that keeping a laptop connected wirelessly to the internet on the lap near the testes may result in decreased male fertility.

Journal ArticleDOI
TL;DR: LNG-IUS12 and LNG-iUS16 provided effective contraception, acceptable bleeding patterns, and were well tolerated compared with Mirena.

Journal ArticleDOI
TL;DR: Patients conceived with ART procedures were at increased risk for several adverse obstetric and perinatal outcomes, regardless of the type of ART procedure used, and maternal factors associated with infertility may contribute to the adverse outcomes rather than the ART procedures themselves.

Journal ArticleDOI
TL;DR: Laroscopic cystectomy of ovarian endometriomas causes a significant and progressive decline in serum AMH levels, and the ovarian reserve damage based on alterations of AMH is assessed.

Journal ArticleDOI
TL;DR: The identification of specific markers for endometrial mesenchymal stem cells and candidate markers for epithelial progenitor cells enables the potential use ofendometrial stem/progenitor cells in reconstructing endometricrial tissue in Asherman syndrome and intrauterine adhesions.

Journal ArticleDOI
TL;DR: A systematic review and meta-analysis of studies that compared the prevalence of anxiety symptoms in women with polycystic ovary syndrome (PCOS) and control women suggests an increased odds of anxiety Symptoms in womenwith PCOS, underscoring the importance of screening all women with PCOS for anxiety symptoms.

Journal ArticleDOI
TL;DR: Human and animal studies are reviewed and an update on the pathophysiology of adenomyosis is provided, highlighting the lack of consensus on the classification of lesions and links with endometriosis.

Journal ArticleDOI
TL;DR: Increased body mass index is associated with elevated triglycerides and free fatty acids in ovarian follicular fluid and maturation within this lipid-rich environment is detrimental to oocytes.