Showing papers in "Fertility and Sterility in 2013"

TL;DR: Infertility prevalence based on a current duration approach was consistent with other US prospective cohort studies with preconception enrollment, and underscores the importance of definition and methodologic approach for estimating the prevalence of infertility.

TL;DR: Blastocyst biopsy with rapid quantitative real-time polymerase chain reaction-based comprehensive chromosomal screening results in statistically significantly improved IVF outcomes, as evidenced by meaningful increases in sustained implantation and delivery rates.

TL;DR: The present review reports the results of 60 orthotopic reimplantations of cryopreserved ovarian tissue performed by three teams, as well as 24 live births reported in the literature to date, finding Restoration of ovarian activity occurred in almost all cases in the three series.

TL;DR: Cleavage-stage biopsy markedly reduced embryonic reproductive potential and in contrast, trophectoderm biopsy had no measurable impact and may be used safely when embryo biopsy is indicated.

TL;DR: There is evidence that IVF outcomes may be improved by performing FET compared with fresh embryo transfer, and this could be explained by a better embryo-endometrium synchrony achieved with endometrium preparation cycles.

TL;DR: In women ≤ 42 years old, transferring a single euploid blastocyst results in ongoing pregnancy rates that are the same as transferring two untested blastocysts while dramatically reducing the risk of twins.

TL;DR: There is an increased percentage of WOI displacement in RIF patients compared with comparison group patients, leading to the concept of pET as a therapeutic strategy.

TL;DR: Most of the newer biologic targeted therapies seem to have only modest effects, mostly on the endocrine aspects of the male reproductive system; however, their effects when used in combination with cytotoxic agents have not been well studied.

TL;DR: For ovarian tissue from patients with hematologic malignancies, it is of paramount importance to identify minimal residual disease before ovarian tissue transplantation, and these pathologies are considered to be most at risk of ovarian metastasis.

TL;DR: Selective transfer of euploid embryos showed that implantation and pregnancy rates were not significantly different between reproductively younger and older patients up to age 42 years, suggesting that the dramatic decline in IVF treatment success rates with female age is primarily caused by aneuploidy.

TL;DR: Experienced embryologists using Eeva in combination with D3 morphology significantly improved their ability to identify embryos that would reach the usable blastocyst stage, and adjunctive use of morphology plus Eeva also reduced interindividual variability in embryo selection.

TL;DR: The ERA is more accurate than histologic dating and is a completely reproducible method for the diagnosis of endometrial dating and receptivity status.

TL;DR: In this article, the authors used transcriptomic profiling of follicular cells to identify biomarkers of oocyte and embryo competence, including Cumulus and mural granulosa cells, which reflect the characteristics of the oocyte, providing a noninvasive means to assess oocyte quality.

TL;DR: Patients who vitrify eggs for medical or nonmedical reasons perform similarly, as observed in this large series of patients, and this technique offers realistic expectations to both groups of patients to have a child with their own eggs.

TL;DR: The removal and cryostorage of ovarian cortical biopsies is now offered as a fertility preservation option for young women, and the only available option to restore fertility using this tissue is by transplantation, which may not be possible for all patients.

TL;DR: This review focuses on the various methodologies used in the discovery of novel biomarkers along with their findings, and specific attention is paid to recent advances in the fields of genetics, proteomics, and metabolomics.

TL;DR: The results reveal an extended number of miRNAs that were differentially expressed in asthenozoospermic and oligoasthenozoespermic males compared with normozoos permic males and provide evidence for analysis of miRNA profiles as a future diagnosing tool for male infertility.

TL;DR: S surveying oocyte cryopreservation patients provides a glimpse into the knowledge base and motivations surrounding current female reproductive practices and may prove to bridge the gap between reproductive prime and when a woman is realistically "ready" to have children.

TL;DR: Female obesity impairs the reproductive outcome of ovum donation probably as a result of reduced uterine receptivity.

TL;DR: This review highlights that although biomarkers of ovarian response started in the IVF clinic, their future extends well beyond the boundaries of assisted reproduction and the automation of AMH and its introduction into the routine repertoire of clinical biochemistry has tremendous potential.

TL;DR: The longest-lived transplanted human uterus to date with acquirement of menstrual cycles is described and is described as the first-year results of the first human uterus transplantation case from a multiorgan donor.

TL;DR: Diverse kinds of bacteria were present in the human semen, but there were no significant differences between sperm donors and infertility patients, and the presence of Anaerococcus might be a biomarker for low sperm quality.

TL;DR: Data from mouse experiments and the in vitro production of livestock provide strong evidence that imprint establishment in late oocyte stages and reprogramming of the two germline genomes for somatic development after fertilization are vulnerable to environmental cues.

TL;DR: NGS can provide blastocyst PGD results with a high level of consistency with established methodologies and could serve as a model for further development of this important and emerging technology.

TL;DR: The live birth probabilities calculated would enable more accurate counseling and informed decisions for infertile women considering oocyte cryopreservation and suggest that policy makers should consider oocyte freezing as an integral part of prevention and treatment of infertility.

TL;DR: The findings project a declining likelihood of pregnancy following intercourse with men >34 years old, independent from the woman's age and increasing with advancing age.

TL;DR: There is a positive relationship between AMH and oocyte yield in GnRH antagonist cycles, and AMH is the best predictor for identifying patients with poor and high ovarian response and cumulative live-birth rates after fresh and cryopreserved cycles reflects the availability of more oocytes/blastocysts, not higher quality.

TL;DR: The important link among the sex steroids, growth factors, cytokines, chemokines, and extracellular matrix and their involvement in cell proliferation, fibrotic processes, apoptosis, and angiogenesis are implicating a complex network in leiomyoma formation and growth.

TL;DR: It is demonstrated that AFC and AMH add value to female age in the prediction of excessive response and that, for AFC and FSH, the discriminatory performance is affected by female age.

TL;DR: The AMH acts through AMHR2 to inhibit FSH-induced adenylyl cyclase activation, aromatase expression, and E2 production, and the mechanism by which AMH exerts its effects is elucidated.