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Showing papers in "Fertility and Sterility in 2014"


Journal ArticleDOI
TL;DR: The lowest risk for embryonic aneuploidy was between ages 26 and 30 and the overall risk did not measurably change after age 43, while the trisomy/monosomy ratio increased minimally with age.

651 citations


Journal ArticleDOI
TL;DR: The results demonstrate the feasibility of live-donor UTx with a low-dose immunosuppressive protocol, and this type of transplantation may become a treatment of absolute uterine-factor infertility (AUFI).

341 citations


Journal ArticleDOI
TL;DR: Repeated 3-month UPA courses effectively control bleeding and shrink fibroids in patients with symptomatic fibroid problems, and NETA did not affect fibroid volume or endometrial histology.

281 citations


Journal ArticleDOI
TL;DR: The results indicate that assays detecting sperm DNA damage should be recommended to those suffering from recurrent failure to achieve pregnancy, and selection of sperm without DNA damage for use may improve the clinical outcome of ART.

276 citations


Journal ArticleDOI
TL;DR: Frozen-thawed BT is associated with improved general perinatal outcomes of pregnancy but significantly increased maternal risks of placenta accreta and PIH, which requires further investigation to assure maternal safety of patients undergoing ART treatment.

274 citations


Journal ArticleDOI
TL;DR: The strategy of culturing and selecting embryos in the integrated EmbryoScope time-lapse monitoring system improves reproductive outcomes.

261 citations


Journal ArticleDOI
TL;DR: ROS and antioxidant capacity testing can potentially add additional prognostic information to standard laboratory testing for the infertile male, although its role as standard part of an evaluation has yet to be determined.

246 citations


Journal ArticleDOI
TL;DR: Retrieval of >15 oocytes significantly increases OHSS risk without improving LB rate in fresh autologous IVF cycles, and less aggressive stimulation protocols should be considered, especially in high-responders, to optimize outcomes.

235 citations


Journal ArticleDOI
TL;DR: Interestingly, success rates after frozen-thawed embryo transfer are now nearing the success rates of fresh embryo transfer, which supports the hypothesis of so called freeze-all strategies in IVF, in which all embryos are frozen and no fresh transfer is conducted, to optimize success rates.

223 citations


Journal ArticleDOI
TL;DR: The need for understanding the mechanistic actions of VD in ovarian physiology and the critical need for randomized trials to elucidate the impact of V D supplementation on controlled ovarian hyperstimulation/IVF outcome and ovulatory dysfunction associated with PCOS is underscored.

218 citations


Journal ArticleDOI
Noora Kotaja1
TL;DR: The current findings that support the central role of miRNAs in the regulation of spermatogenesis and male fertility are discussed.

Journal ArticleDOI
TL;DR: This is the first study reporting extensive preclinical validation and accuracy assessment of NGS-based comprehensive aneuploidy screening on single cells, and NGS has demonstrated a robust high-throughput methodology ready for clinical application in reproductive medicine, with potential advantages of reduced costs and enhanced precision.

Journal ArticleDOI
TL;DR: Semen analysis is the first step to identify male factor infertility and whether assisted reproduction technology (ART) is required depends not only on male factors but female fecundity.

Journal ArticleDOI
TL;DR: There have been reports of greater implantation and pregnancy rates with FET than with fresh autologous embryo transfer, suggesting superior endometrial receptivity in the absence of ovarian stimulation.

Journal ArticleDOI
TL;DR: Luteal-phase ovarian stimulation is feasible for producing competent oocytes/embryos in women undergoing IVF/ICSI treatments, with optimal pregnancy outcomes in FET cycles.

Journal ArticleDOI
TL;DR: This study identified a series of exosomal microRNAs that are highly represented in human FF and are involved in follicular maturation and could represent noninvasive biomarkers of oocyte quality in assisted reproductive technology.

Journal ArticleDOI
TL;DR: Uterine-sparing operative treatment of adenomyosis and its variants appear to be feasible and efficacious and well-designed, comparative studies are urgently needed to answer the multiple questions arising from this intriguing intervention.

Journal ArticleDOI
TL;DR: MicroRNA can be detected in IVF culture media and some of these miRNA are differentially expressed according to the fertilization method, chromosomal status, and pregnancy outcome, which makes them potential biomarkers for predicting IVF success.

Journal ArticleDOI
TL;DR: The largest series to date, suggest that oocyte vitrification does not increase adverse obstetric and perinatal outcomes in children conceived with vitrified oocytes, and further studies with larger samples are required to reinforce the conclusions.

Journal ArticleDOI
TL;DR: Ch Chromosomally normal and abnormal embryos have different kinetic behavior and the proposed algorithm serves as a tool to classify embryos and to increase the probability of noninvasively selecting normal embryos.

Journal ArticleDOI
TL;DR: This is the first multicenter, international collaboration between academic centers and industry addressing standardization of phenotypic data collection for a specific disease, and SSF and MSF are essential tools to increase the understanding of the pathogenesis of endometriosis by allowing large-scale collaborative research into the condition.

Journal ArticleDOI
TL;DR: Resveratrol promoted bovine oocyte maturation and subsequent post-in vitro fertilization embryonic development by inducing progesterone secretion and an antioxidant effect, probably in a manner dependent on sirtuin-1.

Journal ArticleDOI
TL;DR: The EPQ captures the basic set of patient characteristics and exposures considered by the WERF EPHect Working Group to be most critical for the advancement of endometriosis research, but is also relevant to other female conditions with similar risk factors and/or symptomatology.

Journal ArticleDOI
TL;DR: All women with PCOS should be screened for the presence of CV risk factors, since the frequently found derangements at a young age imply an elevated risk for the development of CV disease later in life.

Journal ArticleDOI
TL;DR: Two cases of severe OHSS after GnRH agonist trigger in a GnRH antagonist protocol without the administration of any hCG for luteal-phase support are reported, indicating that even the sequential approach to ovarian stimulation with a freeze-all attitude does not completely eliminate OHSS in all patients.

Journal ArticleDOI
TL;DR: There was a high prevalence of chronic endometritis in women with a history of recurrent early pregnancy loss and the test of cure was 100% with antibiotics, and subsequent LBRs after treatment were encouraging.

Journal ArticleDOI
TL;DR: Select male but not female phthalate exposures were associated with an approximately 20% reduction in fecundity, underscoring the importance of assessing both partners' exposure to minimize erroneous conclusions.

Journal ArticleDOI
TL;DR: Ovaries with endometriomas, which may be more prone to local pelvic inflammation, showed activated follicular recruitment and atresia of early follicles, and the potential contribution of inflammation to follicle "burnout" in case of endometiomas is discussed.

Journal ArticleDOI
TL;DR: Although complications of anabolic steroid-associated hypogonadism (ASIH) are variable and patient specific, they can be successfully managed.

Journal ArticleDOI
TL;DR: Several semen measures were significantly associated with TTP when modeled individually but not jointly and in the context of relevant couple-based covariates.