Showing papers in "Fertility and Sterility in 2016"

TL;DR: Although there is a high prevalence of PCOS, there is increased variability when using Rotterdam 2003 criteria, owing to limitations in population sampling and approaches used to define PCOS phenotypes.

TL;DR: At least 8-10 metaphase II oocytes are necessary to achieve reasonable success in elective fertility preservation and numbers should be individualized in women >36 years old.

TL;DR: The ART singleton pregnancies are associated with higher risks of adverse obstetric outcomes and Obstetricians should manage these pregnancies as high risk.

TL;DR: Clinical relevant criteria that can help to guide the physician in the management of patients with impaired or poor ovarian response are proposed, including a more specific new definition of ‘‘low prognosis’’ patients.

TL;DR: Multicenter, well-designed studies are needed to draw definite conclusions on how to treat CSP, and five approaches for treating CSP are recommended, depending on availability, severity of patient symptoms, and surgical skills.

TL;DR: To decrease morbidity associated with POI, it is recommended using HRT formulations that most closely mimic normal ovarian hormone production and continuing HRT until the normal age of natural menopause, ∼50 years.

TL;DR: This systematic review aims to identify who is at high risk, how to prevent OHSS, and the treatment for existing OHSS.

TL;DR: Treatment outcomes using autologous oocyte vitrification and warming are as good as cycles using fresh oocytes, and age-associated estimates of oocyte to live-born child efficiencies are particularly useful in providing more explicit expectations regarding potential births for elective oocyte cryopreservation.

TL;DR: Office hysteroscopy is a useful diagnostic tool but should be complemented by an endometrial biopsy for the diagnosis of CE, and a high prevalence of immunohistochemically confirmed CE was found in women with RIF and RPL.

TL;DR: Orthotopic transplantation of thawed ovarian tissue is a highly effective measure to restore fertility in sterilized cancer patients and national ethical and professional authorities decide for the first time not to consider OTCP as an experimental modality for fertility preservation.

TL;DR: Stimulation with an identical protocol in the FP and LP of the same menstrual cycle resulted in a similar number of blastocysts in patients with reduced ovarian response, thus increasing the number of patients undergoing transfer per menstrual cycle.

TL;DR: The addition of time-lapse morphokinetic data did not significantly improve clinical reproductive outcomes in all patients and in those with blastocyst transfers, and absence of multinucleation, timing of blastulation, and Morphokinetic score were found to be associated with blastocytes implantation rates.

TL;DR: The reviewed literature indicates that BPA may be associated with infertility in women and may alter overall female reproductive capacity by affecting the morphology and function of the oviduct, uterus, ovary, and hypothalamus-pituitary-ovarian axis in animal models.

TL;DR: Success rates in fresh autologous cycles, including those done for specifically PCOS or male-factor infertility, are highest in those with low and normal BMIs and there is a progressive and statistically significant worsening of outcomes in groups with higher BMIs.

TL;DR: The results of this study demonstrate the efficacy and further support the safety profile of repeated intermittent treatment of symptomatic fibroids with ulipristal acetate and pain and QoL showed marked improvements from screening, even during the off-treatment intervals.

TL;DR: The association between male factor infertility and later health outcomes were strongest for men with longer follow-up, and the overall importance of men's reproductive health is suggested.

TL;DR: Two multivariable models are proposed based on the findings to classify embryos according to their probabilities of blastocyst stage and implantation in the largest data set ever reported of human blastocysts.

TL;DR: Experiments in rodent models demonstrate a key role for seminal fluid in enabling robust embryo implantation and optimal placental development, and it will be important to define the mechanisms through which seminal fluid interacts with female reproductive tissues, to provide knowledge that may assist in preconception planning and infertility treatment.

TL;DR: In a patient without infertility or prior pregnancy loss, it may be reasonable to consider septum incision following counseling regarding potential risks and benefits of the procedure.

TL;DR: Understanding of the control of hemoglobin, heme, and iron-induced redox balance in endometriosis led us to propose a number of hypotheses to explain why oxidative stress is induced in case of pelvic endometiosis.

TL;DR: Next-generation sequencing may detect mosaicism and triploidy more frequently than aCGH, which could help to identify embryos at high risk of miscarriage and increase the risk of first trimester pregnancy loss.

TL;DR: The increase in abnormal sperm parameters, sperm DNA fragmentation, nuclear chromatin decondensation, and sperm aneuploidy suggest possible causes of unexplained RPL.

TL;DR: Several miRNAs in serum that distinguished subjects with endometriosis from those without were identified and miR-125b-5p had the greatest potential as a single diagnostic biomarker.

TL;DR: The results confirm the known inverse relationship between advanced maternal age (>35 years) and embryo euploidy, demonstrating that equal numbers of eUploid embryos are available at day 3 and day 5, and suggest that the loss of embryos from day 3 to day 5 was primarily due to aneuploids.

TL;DR: The findings of low birth and very low birth weight after thawed frozen embryo transfer are consistent with the literature and provide reassurance regarding the outcome of pregnancies after frozen embryo transfers, however, they highlight the possibility of high birth weight in these babies.

TL;DR: The choice between the different FSS procedures depends first and foremost on the oncologic characteristics of the tumor, and fertility results should be taken into consideration to select the best choice acceptable to the patient/couple.

TL;DR: MicroRNAs secreted from human blastocysts in culture media can be profiled with high reproducibility, and this approach can be further explored for noninvasive embryo selection.

TL;DR: Estrogen-progestins and progestins reduce the incidence of postoperative endometricrioma recurrence and show a protective effect against endometriosis-associated epithelial ovarian cancer risk.

TL;DR: In this paper, the authors used the Nanostring nCounter GX Human Immunology V2 platform (579 human immune and inflammation-related genes and 15 housekeeping genes) to determine if the molecular profiles of endometriotic lesions contain informative measures of inflammation and immune dysfunction that may contribute to better understanding of the interplay between immune dysfunction and inflammation.

TL;DR: Enhancing oocyte competence is a key intervention that promises to reduce the number of euploid embryos failing to produce viable deliveries and methods to reduce stress or the body's reaction to stress improve pregnancy success.