Showing papers in "Fertility and Sterility in 2017"

TL;DR: A consensus-based and evidence-driven set of 283 terminologies used in infertility and fertility care was generated to harmonize communication among health professionals and scientists as well as the lay public, patients and policy makers.

TL;DR: The worldwide upward trend in obesity has been dramatic, now affecting more than 20% of American women of reproductive age, and many interventions have been explored to mitigate the effect of obesity on infertility, including weight loss, physical activity, dietary factors, and bariatric surgery.

TL;DR: Preimplantation genetic diagnosis for aneuploidy screening is superior compared with controls not only in clinical outcome at the first ET but also in dramatically decreasing miscarriage rates and shortening the time to pregnancy.

TL;DR: The many causes of obesity are described, including key roles that a dysbiotic intestinal microbiome plays in metabolic derangements accompanying obesity, increased calorie absorption, and increased appetite and fat storage.

TL;DR: The results suggest that embryos with >40% abnormal cells and those with multiple mosaic abnormalities (chaotic mosaics) are likely to have lower OIRs and should be given low transfer priority.

TL;DR: Based on American Society for Reproductive Medicine (ASRM) and Society for Assisted Reproductive Technology data available through 2014, ASRM's guidelines for the limits on the number of embryos to be transferred in in vitro fertilization (IVF) cycles have been further refined in continuing efforts to promote singleton gestation and reduction of multiple pregnancies.

TL;DR: In this paper, epigenetic reprogramming of spermatogonial stem cells has been used to understand the impact of obesity on subsequent generations, and conveying the impact on future progeny can serve as a powerful tool for obese men to modify their behavior.

TL;DR: Optizing ovarian response in IVF by individualized dosing according to pretreatment patient characteristics results in similar efficacy and improved safety compared with conventional ovarian stimulation.

TL;DR: Unifying concepts regarding changes and how they are coordinated to promote progesterone resistance and estrogen dominance through aberrant cell signaling pathways and reduced expression of key homeostatic proteins in eutopic endometrium of women with endometriosis are provided.

TL;DR: Children conceived by IVF-ICSI manifested a minor yet statistically significant increase in blood pressure without the clustering of increased BMI or impaired lipid metabolism by early adulthood, which indicates a risk of cardiovascular disease among IVF -ICSI offspring.

TL;DR: Surgeons should consider rectal shaving as a first-line surgical treatment of rectovaginal DE, regardless of nodule size or association with other digestive localizations, as well as laparoscopy or transanal staplers.

TL;DR: In conclusion the pathophysiology of deep endometriosis remains debated and the mechanisms of disease progression, as well as the role of genetics and epigenetics in the process, still needs to be unraveled.

TL;DR: Fertility preservation techniques have been widely adopted over the last decade and therefore the establishment of international registries on their short- and long-term outcomes is strongly recommended, and the level of evidence for most of the evidence reviewed was 3 or below.

TL;DR: It appears that surgical treatment or treatment withf GnR Ha increases the spontaneous pregnancy rate in women with adenomyosis, and Pretreatment with the use of long-term GnRHa or long protocol could be beneficial.

TL;DR: Advances in imaging techniques offer high sensitivity and specificity to diagnose DE with at least triage value and for rectosigmoid endometriosis replacement value imposing a revision of the concept of laparoscopy as the gold standard.

TL;DR: The importance of eutopic endometrium as a source of potential diagnostic biomarkers by looking at the expression levels of noncoding RNA in tissue as well as in blood is highlighted.

TL;DR: It is demonstrated that the extent of mosaicism influences the IVF success rate and the results of this study further confirm that mosaic embryos can develop into healthy euploid newborns.

TL;DR: Women with endometriosis have a statistically significantly higher risk of preterm birth, miscarriage, placenta previa, small for gestational age infants, and cesarean delivery.

TL;DR: Few studies of medical therapies for endometriosis report outcomes that are relevant to patients, and many women gain only limited or intermittent benefit from treatment.

TL;DR: The validation of methods that permit the detection of chromosomal mosaicism in IVF embryos and findings of clinical relevance are discussed.

TL;DR: Testicular sperm have lower levels of SDF than ejaculated sperm, with Testi-ICSI for high post-testicular SDF men improving reproductive outcomes compared with Ejac- ICSI, and infertile couples may benefit from Testi -ICSI if male partners have confirmed high SDF in the ejaculate.

TL;DR: Either treatment protocol investigated in the present study can be a reasonable option for patients, and a trend toward favoring the freeze-all option as a preferred transfer strategy when using known euploid embryos is suggested.

TL;DR: A large-scale PCOS survey, conducted in response to patient concerns regarding diagnosis and treatment, highlights opportunities for physician education and focuses on targeting knowledge of internationally accepted Rotterdam criteria.

TL;DR: The current literature that surrounds the endometrial microbiome is reviewed and the importance of assessing it as a future tool for improving reproductive outcomes in infertile patients is highlighted.

TL;DR: There is fair evidence that metformin alone does not increase rates of miscarriage when stopped at the initiation of pregnancy and insufficient evidence that meetingformin in combination with other agents used to induce ovulation increases live-birth rates.

TL;DR: A model for live birth prediction after strict SET was constructed and showed excellent calibration in internal validation, and for the first time, female height qualified as a predictor of live birth after IVF/ICSI.

TL;DR: In symptomatic women with residual myometrial thickness of less than 3 mm who wish to conceive, laparoscopic repair could be considered an appropriate approach.

TL;DR: Overall levels of mtDNA are largely equal between blastocysts stratified by ploidy, age, or implantation potential, and the correction factor calculation is recommended to laboratories evaluating mtDNA levels in embryos by NGS or qPCR.

TL;DR: A wider range of medical options allows for the possibility of precision health and a more personalized treatment approach for women with endometriosis.

TL;DR: Both norethindrone acetate and dienogest have regulatory approval for treating endometriosis and may be better than OCPs as a first-line therapy, and there is randomized, controlled trial data to support the use of oral progestin-only treatment for pelvic pain associated with endometRIosis.