scispace - formally typeset

JournalISSN: 0367-326X

Fitoterapia 

About: Fitoterapia is an academic journal. The journal publishes majorly in the area(s): Antibacterial agent & Essential oil. It has an ISSN identifier of 0367-326X. Over the lifetime, 5465 publication(s) have been published receiving 139406 citation(s).
Papers
More filters

Journal ArticleDOI
TL;DR: The aim of this review is to discuss both the antioxidant and prooxidant effects of flavonoids.
Abstract: The interest in possible health benefits of flavonoids has increased owing to their potent antioxidant and free radical scavenging activities observed in vitro. Nevertheless, the antioxidant efficacy of flavonoids in vivo is less documented and their prooxidant properties have been actually described in vivo. Due to their prooxidant properties, they are able to cause oxidative damage by reacting with various biomolecules, such as lipids, proteins and DNA. Hence, the aim of this review is to discuss both the antioxidant and prooxidant effects of flavonoids.

981 citations


Journal ArticleDOI
Stefano Castaldo, Francesco Capasso1Institutions (1)
TL;DR: Propolis is one of the few natural remedies that has maintained its popularity over a long period of time and has anti-inflammatory and immunomodulatory activities and has been shown to lower blood pressure and cholesterol levels.
Abstract: Propolis is one of the few natural remedies that has maintained its popularity over a long period of time. The pharmacologically active molecules in the propolis are flavonoids and phenolic acids and their esters. These components have multiple effects on bacteria, fungi and viruses. In addition, propolis and its components have anti-inflammatory and immunomodulatory activities. Moreover, propolis has been shown to lower blood pressure and cholesterol levels. However, clinical studies to substantiate these claims are required.

600 citations


Journal ArticleDOI
Marcello Duranti1Institutions (1)
TL;DR: The most relevant putative positive effects of grain legumes on human health are reported to give an account of the current knowledge on the demonstrated legume seed protein biological activities and the prospects on targeted legume protein exploitation in the nutraceutical area are considered.
Abstract: Grain legumes are a valuable source of food proteins. Their exploitation is expected to grow in relation of a growing world's food needs. Moreover, it is currently taking place a reappraisal of the beneficial effects of legume seed dietary intake, which are the basis for various health claims. Proteins and peptides concur to the observed biological activities of legume seeds, but their effect(s) has(ve) not completely been disclosed. Aims of this review are: to report the most relevant putative positive effects of grain legumes on human health and to give an account of the current knowledge on the demonstrated legume seed protein biological activities. Specific effects on the prevention and treatment of various diseases, mostly of which are typical of the affluent countries, are reported. Examples of studies at molecular level aimed at elucidating of the underlying mechanism(s) are given. The prospects on targeted legume protein exploitation in the nutraceutical area, including the biotechnological approaches, are also considered.

476 citations


Journal ArticleDOI
Hildebert Wagner1Institutions (1)
TL;DR: Gallocatechins of green tea and curcuminoids of ginger are the presently favoured polyphenols for a possible future use in co-medication with antibiotics and standard anticancer drugs and the main targets were found to be COX 1+2, NF-κB, and membrane glycoproteins that belong to the ATP-binding cassette (ABC) transporter family.
Abstract: The longstanding, successful use of herbal drug combinations in traditional medicine demands that we find a rationale for their comparative pharmacological and therapeutic superiority to isolated single constituents. The synergistic efficacy of these combinations can be evaluated and verified by Berenbaum's isobole method, followed by clinical studies performed in comparison with synthetic standard drugs. There are many examples of mono- and multi-extract combinations used presently, which exhibit synergistic efficiency based on multi-target mechanisms of action. Among the natural products, gallocatechins of green tea and curcuminoids of ginger are the presently favoured polyphenols for a possible future use in co-medication with antibiotics and standard anticancer drugs. The main targets were found to be COX 1+2, NF-κB, and membrane glycoproteins that belong to the ATP-binding cassette (ABC) transporter family.

401 citations


Journal ArticleDOI
Gabriele D'Andrea1Institutions (1)
TL;DR: In this review the molecular, cellular, and functional bases of therapy will be emphasized taking strictly into account data appearing in the peer-reviewed literature and summarizing the main therapeutic applications of quercetin, the drug metabolism and the main drug interaction as well as the potential toxicity will be also spotlighted.
Abstract: Great interest is currently centered on the biologic activities of quercetin a polyphenol belonging to the class of flavonoids, natural products well known for their beneficial effects on health, long before their biochemical characterization. In particular, quercetin is categorized as a flavonol, one of the five subclasses of flavonoid compounds. Although flavonoids occur as either glycosides (with attached glycosyl groups) or as aglycones, most altogether of the dietary intake concerning quercetin is in the glycoside form. Following chewing, digestion, and absorption sugar moieties can be released from quercetin glycosides. Several organs contribute to quercetin metabolism, including the small intestine, the kidneys, the large intestine, and the liver, giving rise to glucuronidated, methylated, and sulfated forms of quercetin; moreover, free quercetin (such as aglycone) is also found in plasma. Quercetin is now largely utilized as a nutritional supplement and as a phytochemical remedy for a variety of diseases like diabetes/obesity and circulatory dysfunction, including inflammation as well as mood disorders. Owing to its basic chemical structure themost obvious feature of quercetin is its strong antioxidant activity which potentially enables it to quench free radicals from forming resonance-stabilized phenoxyl radicals. In this review the molecular, cellular, and functional bases of therapy will be emphasized taking strictly into account data appearing in the peer-reviewed literature and summarizing the main therapeutic applications of quercetin; furthermore, the drug metabolism and the main drug interaction as well as the potential toxicity will be also spotlighted.

397 citations


Network Information
Related Journals (5)
Journal of Ethnopharmacology

14.1K papers, 648.6K citations

92% related
Planta Medica

15.9K papers, 311.4K citations

91% related
Journal of Natural Products

14.3K papers, 467.9K citations

91% related
Phytotherapy Research

7K papers, 240.8K citations

90% related
Phytomedicine

4.6K papers, 157.2K citations

88% related
Performance
Metrics
No. of papers from the Journal in previous years
YearPapers
202213
2021196
2020271
2019301
2018296
2017208