Showing papers in "Fitoterapia in 2015"

TL;DR: In this review the molecular, cellular, and functional bases of therapy will be emphasized taking strictly into account data appearing in the peer-reviewed literature and summarizing the main therapeutic applications of quercetin, the drug metabolism and the main drug interaction as well as the potential toxicity will be also spotlighted.

TL;DR: The aim of this updated review is to highlight the importance of coriander as a potential source of bioactive constituents and to summarize their biological activities as well as their different applications from data obtained in recent literature, with critical analysis on the gaps and potential for future investigations.

TL;DR: The present review shall summarize recent studies on various biotransformation and pharmacological activities of CK.

TL;DR: In this article, extracts of pomace from Riesling grapes were analyzed for their inhibitory properties on collagenase as well as elastase, and the most pronounced impact was found for the hydrophilic low molecular weight polyphenols containing the free phenolic acids.

TL;DR: It is shown that the extracts as well as (-)-hydroxycitric acid (HCA), a main organic acid component of the fruit rind, exhibited anti-obesity activity including reduced food intake and body fat gain by regulating the serotonin levels related to satiety, increased fat oxidation and decreased de novo lipogenesis.

TL;DR: This review illustrates druggability optimization of NPs through structural modification with some successful examples.

TL;DR: Petals of C. sativus L. have commercial potential as a source for kaempferol and crocetin glycosides, natural compounds with antioxidant activity that are considered to be the active ingredients in saffron-based herbal medicine.

TL;DR: This review summarizes the current knowledge about the neuroprotective effects of ITCs in counteracting oxidative stress as well as inflammatory and apoptotic mechanisms, using in vitro and in vivo models of acute and chronic neurodegenerative disease.

TL;DR: The results of the present study revealed the anti-quorum sensing activity of zingerone targeting ligand-receptor interaction, hence proposing zinger one as a suitable anti-virulent drug candidate against P. aeruginosa infections.

TL;DR: Results strongly indicate that PO could exert a gastro-protective effect against gastric ulceration, and the underlying mechanism might be associated with the stimulation of PGE2, improvement of antioxidant and anti-inflammatory status, as well as preservation of NP-SH.

TL;DR: This review aims at summarizing the inventory of polyacetylenes occurring in terrestrial eukaryotic organisms (plants and fungi) during the last 15 years, and at discussing progress in their bioactivities and in the identification of their biological targets.

TL;DR: DLD-1 assays identified strong anti-proliferative activity associated with these components as well as chrysin, galangin and CAPE and a number of lesser known or lower concentration compounds including benzyl ferulate, benzyl isoferulate, pinostrobin, 5-phenylpenta-2,4-dienoic acid and tectochrysin.

TL;DR: Findings suggest that the flavone chrysin isolated from P. evestita Th.

TL;DR: Three new lanostane-type triterpenes, inonotusanes A-C (1-3), and a new naturally occurring one, 3β-hydroxy-25,26,27-trinorlanosta-8,22E-dien-24-oic acid (4), together with sixteen known triter penoids (5-20), including 13 Lanostane derivatives, 2 lupanes and 1 oleanane- type triter

TL;DR: Five new eudesmane-type sesquiterpenoids were isolated from Chinese agarwood induced by artificial holing originating from Aquilaria sinensis (Lour.) Gilg (Thymelaeaceae) and showed antibacterial activities and weak acetylcholinesterase inhibitory activity.

TL;DR: This comprehensive review provides information on the potentiality of bergenin and its derivatives for therapeutic usages in herbal and Ayurvedic formulations until 2013.

TL;DR: Four oleanane-type triterpenoid saponins were isolated from the seed cake of Camellia oleifera Abel and showed significant cytotoxic activities and the anti-proliferative activities of these four compounds were investigated on human tumor cell lines.

TL;DR: This work reviews the research on the occurrence, isolation, identification, biological activities, and biosynthesis of this class of compounds published from 1995 till now and describes more than 125 metabolites.

TL;DR: Clinical studies pertaining to the anti-cancer, anti-diabetes as well as anti-inflammatory activities of the Evodiamine and its derivatives would possess important market potential for the development of Evodia rutaecarpa based therapeutics.

TL;DR: Results revealed interesting bioactivities and differences between polar extracts and essential oils, with the former being endowed with significant antioxidant activity and the latter with comparable inhibition effects on the tumor cells to that of cisplatin.

TL;DR: The results demonstrated that the ethanol extract of FP displayed potent inhibitory effects towards hCE2, while five major bioactive constitutes in FP were efficiently identified by LC-DAD-ESI-MS/MS, with the aid of LC-based activity profiling.

TL;DR: It is demonstrated that cryptotanshinone is able to inhibit in a concentration dependent manner the rat platelet aggregation and also is endowed of Gi-coupled P2Y12 receptor antagonist as demonstrated by docking studies.

TL;DR: Vindogentianine exhibited potential hypoglycemic activity in β-TC6 and C2C12 cells by inducing higher glucose uptake and significant in vitro PTP-1B inhibition, implying its therapeutic potential against type 2 diabetes.

TL;DR: The results suggest that the solid dispersion preparation by HME could serve as a promising formulation approach to enhancing the dissolution rate and oral bioavailability of GBE.

TL;DR: Three new monoterpenoid indole alkaloids were isolated from the leaves of Alstonia scholaris cultivated in Kunming, and exhibited significant antibacterial activity against Enterococcus faecalis, and 3, 9 and 14 against Pseudomonas aeruginosa.

TL;DR: It was established that five of the 30 Helichrysum species selected for this study had significant anti-HIV activity ranging between 12 and 21 μg/mL (IC50) by using an in-house developed DeCIPhR method on a full virus model, which revealed little or no toxicity for these active extracts.

TL;DR: Results showed that high fat and high cholesterol induced obese hamsters were used to evaluate the anti-inflammation and hypolipidemic role of coptisine, and the results of endotoxin neutralization assay suggest that copt cuisine is capable of reducing the LPS content under inflammation status.

TL;DR: The knowledge about Belamcandae chinensis rhizoma has been growing rapidly in the recent years,but there are still significant gaps in the authors' understanding of its bioactivity, therapeutic value, and roles played by each of the numerous phytochemicals.

TL;DR: A large number of targets of diterpenes have been identified in cancer cells including NF-κB, STAT3, Bcl-xL, β-catenin, cytochrome C and caspases, which give deeper insights into the mechanisms of actions and cell signaling pathways of anticancer diter penoids from Salvia species.

TL;DR: Conclusively, GBA may inhibit HIF-1 activation through down-regulation of its subunit expression in hypoxia, and increasing of EGFR degradation in normoxia and downstream genes contributed in glycolysis are underexpressed in GBA treated cells in Hypoxia.