Showing papers in "Fitoterapia in 2016"

TL;DR: This review summarized recent findings on various pharmacological activities and associative signalling pathways of vitexin and isoviteXin to provide a reference for future research and clinical applications.

TL;DR: BBR is a promising drug candidate for metabolic disorders and cancer but faces considerable challenges due to its poor oral bioavailability.

TL;DR: The purpose of this review is to provide an overview of current knowledge about the antIfungal properties and antifungal mode of action of cinnamaldehyde and its derivatives and to identify research avenues that can facilitate implementation of cunnamaldehyde as a natural antifundal.

TL;DR: The present paper comprehensively reviewed the traditional uses, fermentation, constituent and pharmacology of Phellinus linteus based on scientific literature as well as critical analysis of the research to provide helpful references and beneficial directions for future studies of the fungus.

TL;DR: In this review, the papers appeared in the last 15years are evaluated and the most significant data is critically collected, to better understand the role of whole herbal extracts in exerting their photo protective activity.

TL;DR: In this paper, the effect of cannabidiol and moringin on lipopolysaccharide-stimulated murine macrophages was investigated in a comparative way.

TL;DR: Thecell growth inhibition for fast growing cells together with the cell growth inhibition of prostate-, breast- and colon cancer cells corroborates the ethnomedical use of pumpkin seeds for a treatment of benign prostate hyperplasia and, due to the lack of androgenic activity, pumpkin seed applications can be regarded as safe for the prostate.

TL;DR: In vitro results demonstrated the antitumor efficacy of moringin derived from myrosinase-hydrolysis of GMG in human malignant astrocytoma cells.

TL;DR: Three new tetracyclic triterpenoids namely, integracides H (1), I (4), and J (5) have been isolated from the endophytic fungus Fusarium sp.

TL;DR: The micromorphological and histochemical study showed that iridoids and essential oil are mainly produced in the type III capitates and peltate trichomes of leaves and flowers and were more potent as radical scavengers than the latter.

TL;DR: The recovered polyphenol fraction RF20-SP207 from RODW was found to be a potent tyrosinase inhibitor and could be used as an active ingredient in cosmetic products related to hyperpigmentation.

TL;DR: Phospholipid complexation might be one of the suitable approaches to improve the oral bioavailability of QT and obtain better protective effects against CCl4 induced acute liver damage in SD rats than free QT at the same dose level.

TL;DR: Biological activity test indicated that compounds 1-3, and 7 exhibited the inhibitory effects on influenza viral strain of A/Puerto Rico/8/34 (H1N1) with the IC50 values of 2.59, 8.35, 7.82, and 0.80μg/mL, displaying a promising potential of 7 in the development of anti-influenza A virus drugs.

TL;DR: Three new butenolides containing 5-hydroxyfuran-2(5H)-one core, asperteretal A (1), aspereretal B (2), and aspertereal C (3), together with seven known butenolsides (4-10), were obtained from an endophytic fungus Aspergillus terreus PR-P-2 isolated from the plant Camellia sinensis var.

TL;DR: The phytochemical characteristics and anticancer activity of the cardenolides from this family are compiled to exhibit the capability to regulate cancer cell survival and death through multiple signaling pathways.

TL;DR: The mechanisms via topically applied products containing herbs and their active constituents affect the hair growth process and the knowledge summarized in the paper may be an inspiration to create new preparations for the treatment of hair loss.

TL;DR: Compounds 4 and 6-9, featuring a cochlioquinone core, exhibited potent cytotoxicities in vitro against the four tumor cell lines, and a preliminary structure-activity relationship of these compounds was also discussed.

TL;DR: A bio-analytical platform combining high-resolution PTP1B inhibition profiling and high-performance liquid chromatography-high-resolution mass spectrometry-solid-phase extraction-nuclear magnetic resonance spectroscopy, i.e., HR-bioassay/HPLC-HRMS-SPE-NMR is developed, which led to the identification of the first viscidane type diterpene from E. lucida.

TL;DR: Overall, the results indicate that vigno 5 induces apoptosis in part via the mitochondrial pathway, which is associated with a release of cytochrome C and elevated activity of caspase-9 and -3 in Hela cells.

TL;DR: Seven new 2-(2-phenylethyl)chromone derivatives (1-7) including a chlorinated one (4), together with eight known ones (8-15), were isolated from the EtOAc extract of artificial agarwood originating from Aquilaria sinensis (Lour.) Gilg.

TL;DR: Peimine was not only able to block the Nav1.7 ion channel but also preferably inhibited the Kv1.3 ion channel, suggesting potential mechanisms of Fritillaria as a pain relieving and anti-inflammatory herb.

TL;DR: Identification of these metabolites of acteoside by the intestinal bacteria or intestinal enzyme gave an insight to clarify pharmacological mechanism of traditional Chinese medicines and identify the real active molecules.

TL;DR: Results showed that administration of monotropein for four weeks exerted good bone protective effects as evidenced by the increase of bone mineral content (BMC), bone mineral density (BMD), bone volume fraction (BVF) and improvement of bone microstructure.

TL;DR: This review summarizes the updated knowledge about the chemical structures of about forty centelloids, found as minor metabolites in Centella, and all derived from ursane and oleane ring patterns, and reviews the most recent genetic and enzymatic features involved in their biosynthesis.

TL;DR: A new steroidal saponin, furotrilliumoside, isolated from the roots and rhizomes of Trillium tschonoskii Maxim might act as a natural agent to treat some inflammatory diseases by targeting PI3K/Akt, MARK and Nrf2/HO-1 pathways.

TL;DR: The CCS strategy enables recovery of target metabolites from NADES-containing crude extracts as well as from other chemical mixtures, and moreover offers a means of using NADES as environmentally friendly extraction solvents.

TL;DR: Six new physalin steroids were isolated from calyces of Physalis alkekengi var.

TL;DR: The results showed that each fraction predominantly owned a single compound and gave a high yield with (-)-epicatechin, A-type dimers (A1 and A2) and trimer, suggesting a useful method to obtain pure (-)-Epicatechin and A- type oligomeric procyanidins.

TL;DR: Four new compounds (1, 2, 7 and 8) and twenty known compounds were isolated from the flower buds of Lonicera japonica and all the isolates were evaluated for their inhibitory effects on α-glucosidase and protein tyrosine phosphatase 1B, especially 1 and 2, which displayed both significant inhibitions.

TL;DR: The data suggest that Nar should be a direct ERRα inhibitor capable of inhibiting angiogenesis in vitro and in vivo, including endothelial cell proliferation, survival, migration and capillary-like structures formation of HUVECs, as well as reduced neovascularization of the CAM.