Showing papers in "Fitoterapia in 2018"
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TL;DR: In this article, a review compiles literature information on the ethno-medicinal, phytochemistry and pharmacological properties of species in the genus Cordyceps.
85 citations
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TL;DR: Several natural products, belonging to diverse chemical families, are potent chemosentisizers in tumor cells enhancing the cytotoxicity of conventional drugs.
70 citations
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TL;DR: Seven new phenolic bisabolane sesquiterpenoids, along with five known analogues (8-12), were obtained from the culture of an endophytic fungus Aspergillus sp.
57 citations
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TL;DR: Making traditional medicine injectable might be a promising way to develop traditional medicines, however, many practical challenges need to be overcome by further development before a brighter future for injectable traditional medicines can reasonably be expected.
51 citations
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TL;DR: The in vitro results data suggest that olive biophenols could be a promising natural inhibitor, which may reduce the enzyme-induced toxicity associated with the oxidative stress involved in the progression of AD.
50 citations
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TL;DR: The structure-based virtual ligand screening in a small in-house database of natural products predicted that a new steroid from Ganoderma sinense has high binding affinity to HK2, and compound 2 was identified as an HK2 inhibitor.
50 citations
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TL;DR: The obtained results demonstrated the antioxidant, cytoprotective and anti-angiogenic properties of BCCE, which highlight that the higher biological activity of BCCe is probably due to the synergic effects exerted by various polyphenolic classes.
48 citations
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TL;DR: The present review focuses only on the depsidones that have been isolated from fungal source and published from 1978 to 2018, and outlined the research on the biosynthesis, source, isolation, spectral and physical data, and bioactivities of the naturally occurring fungal depsids.
41 citations
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TL;DR: The results of study showed that the same amount of α-pinene with different enantiomeric composition can have diverse antimicrobial potential due different specific interactions with other chemical compounds of essential oil.
41 citations
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TL;DR: The results provide evidence for traditional application of motherwort water decoction and its Chinese patent medicines to promote postpartum recovery, and indicated, for the first time, that motherworts alkaloids were potent angiogenic agents, while even low concentrations ofmotherwort essential oil were toxic.
38 citations
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TL;DR: Three new compounds, isolated from the Portulaca oleracea L. for the first time, were identified and their structures were elucidated using spectroscopic methods, including one- and two-dimensional nuclear magnetic resonance, high-resolution electrospray ionization time-of-flight mass spectrometry and circular dichroism spectromaetry.
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TL;DR: Compounds 4a and 4e represented equivalent antifungal activity with Boscalid against Botrytis cinerea and some of the designed compounds 4a-4g exhibited potential activity in the primary assays, exhibiting more effective control with that of the positive control than BosCalid.
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TL;DR: DHA was effective in the elimination of L. amazonensis both in its promastigote forms by apoptosis-like mechanisms and intracellular form by ROS production, and also caused downregulation of Nrf2 and ferritin expression.
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TL;DR: These are the first optically pure examples in the 3-arylisoindolinone family, which are rarely found in natural sources and found to inhibit nitric oxide production in RAW 264.
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TL;DR: The article presents the current state of phytochemical research on the generative and vegetative organs of the plant and promotes N. officinale as a very valuable species, not yet fully discovered by global medicine.
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TL;DR: Comparative molecular docking results have shown a higher stability of the ALR2-cannabinoid acids complex than the other inhibitors, which may have some relevance for the possible use of C. sativa chemotypes based preparations as aldose reductase inhibitors.
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TL;DR: A successive ranking strategy based on a comprehensive review of the literature and metabolomic data in order to relate ethnopharmacological relevance to chemical entities of interest is applied to Southeast Asian plants traditionally used to treat liver disorders.
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TL;DR: During a metabolomics screen of 86 Salix species contained in the UK National Willow Collection, a new natural salicinoid is discovered, isolated and fully characterised – salic in-7-sulfate.
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TL;DR: The results support the use of BEO in aromatherapy for complementary management of chronic pain relief in a stepwise therapeutic programme and reduce the formalin-induced licking/biting behaviour in a manner that was dependent on the volume of B NEO used in the device for its release and on the time of exposure to the phytocomplex.
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TL;DR: Ocotillol-type ginsenosides, which have prominent anti-Alzheimer's disease activity, are focused on, but have been overlooked previously, such as its representative compound-Pseudoginsenoside F11(PF11), to provide a reference for the druggability and further developments of ocotilol- type ginsenoides by utilizing the homogeneous structure between dammarane-type and ocotillosomes.
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TL;DR: Results partially support the traditional usage of infusion from lime flowers in the treatment of symptoms of inflammation and irritation of mucosa in common cold, pharyngitis and tonsillitis.
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TL;DR: Alkaloids 3-5 exhibited some cytotoxicity against all of seven tested tumor cell lines and possessed significant antimicrobial and antifungal activities which was reported for the first time for the alkaloids isolated from Kopsia genus.
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TL;DR: Monoterpenoid 4 and alkaloid 15 showed remarkably inhibitory effect on the production of inflammatory mediator (NO) and pro-inflammatory cytokines (TNF-α and/or IL-6) in LPS-stimulated RAW264.7 cells.
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TL;DR: It is found that the production of pro-inflammatory mediators induced by LPS was significantly suppressed by β-elemene in a dose-dependent manner in RAW264.7 macrophage cell line, and β- elemene may serve as potential nontoxic modulatory agents for the prevention and treatment of inflammatory diseases.
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TL;DR: This investigation enriched the present understanding of cocrystals on their behavior in vitro and in vivo, and built the groundwork for future development of BE as a promising compound into efficacious drug products.
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TL;DR: A new alkaloid, 1,2-dihydrophenopyrrozin, along with five known compounds, was isolated from an axenic culture of the endophytic fungus, Bionectria sp.
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TL;DR: The preliminary structure-activity relationships of the ent-atisane diterpenoids inhibiting α-glucosidase were discussed and a putative biosynthetic pathway was proposed for ent-seco-atisanes diter penoids.
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TL;DR: The status of plant extracts and traditional medicines in ameliorating the toxicity of paraquat is discussed and novel compounds with antioxidant and/or anti-inflammatory properties are explored.
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TL;DR: Four new dihydrophenanthrenofuran, bleochranols A-D, along with 21 known compounds including phenanthrenes and bibenzyls were isolated and elucidated from the rhizomes of Bletilla ochracea, showing remarkable cytotoxic activity against HL-60, A-549, and MCF-7 and anti-inflammatory activity against NO production in LPS-stimulated RAW 264.
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TL;DR: Chemical investigation of the embryos of Nelumbo nucifera afforded four new flavone C-glycosides, named nelumbosides A-D (1-4), together with nine known ones, comprising five flavonoids (5-9) and four alkaloids (10-13).