Showing papers in "Fitoterapia in 2021"

TL;DR: In this article, a review article describes the recent progress in the discovery, structural modification, and structure-activity relationship studies of potent anti-HIV coumarin-based derivatives including natural Coumarin compounds, synthetic hybrids, dimers, and other synthetic derivatives covering articles published between 2000 and 2020.

TL;DR: In this paper, Ginkgo biloba leaves extract (GBLE) was found with the most potent SARS-CoV-2 3CLpro inhibition activity (IC50 = 6.68 ǫg/mL).

TL;DR: This comprehensive review describes the advances in the chemical analysis, including sample preparation methods, qualitative and quantitative analysis and biological specimen analysis, based on 113 references for the recent years and newly established methods are summarized.

TL;DR: In this paper, the authors reported the antioxidant activity of cannabigerol (CBG), cannabidiol (CBD), cannabinol (CBN), CBGA, cannabinolic acid (CBDA), Δ9-tetrahydrocannabinolic acid(Δ9-THCA), and cannabinol(CBN) estimated by spectrophotometric methods: ABTS, DPPH, ORAC, and CUPRAC.

TL;DR: Among all the isolated new compounds, 4 is reported as the first enantiomeric form of novel eremophilanolide type sesquiterpenoid, which presented moderate anti-inflammatory activity by inhibiting the release of pro-inflammatory cytokines in LPS-stimulated N9 cells.

TL;DR: Crocins, as a kind of water-soluble carotenoid pigment, are a series of ester compounds formed from crocetin and gentibiose or glucose, and mainly distributed among Crocus sativus L. (CSL), Gardenia jasminoides Ellis (GJE).

TL;DR: In this article, the secondary metabolite of Aspergilluone A (1) was elucidated by 1D and 2D nuclear magnetic resonance (NMR) spectroscopic and mass spectrometric analyses.

TL;DR: In this paper, the composition of Senegalese propolis and its anti-inflammatory properties were analyzed and compared to other previously reported propolis components, including beeswax and plant resins.

TL;DR: In this paper, the effects of Cinnamomum cassia (Cinnamon) on thermogenesis were evaluated on body temperature and activation of brown adipose tissue using HPLC-Q-TOF/MS and screened with databases.

TL;DR: In this paper, the exudates of thirty-nine South African Aloe species were screened to identify species and compounds with anti-tyrosinase activity, and the results revealed that twenty-nine aloe species exhibited tyrosinases inhibition activity with one to three active bands.

TL;DR: A new skeleton flavonoid, identified as (5aR)-10-hydroxy-8methoxy-5aH,11H-chromeno[2,3-b]chromen-11-one (1), named oleracone G, and a new lignan, confirmed as 8-(4-hydrox-3-methoxyphenyl)-3 methoxynaphthalen-2-ol (2), named oleralignan B, were isolated from Portulaca oleracea L., and the

TL;DR: In this article, two novel kojic acid derivatives, Kojicones A and B (1 and 2), along with the precursors kjic acid (3) and (2R,4R)-4-hydroxy-5-methoxy-2,4-dimethyl-2- [(2R)-2-methylbutyryloxy]-5-cyclohexen-1,3-dione (4), were isolated from a fungal strain Aspergillus versicolor.

TL;DR: Results indicated that novel benzimidazole-containing myricetin derivatives can be used as a potential antibacterial reagent and showed the best inhibitory activities against Xoo.

TL;DR: In this article, six new metabolites, including two diphenolic derivatives (1 and 2), one pseurotin (3), one butenolide derivative (4), one benzopyran (5) and one isochromane lactone (6), together with ten known compounds (7, 16) were isolated from an endophytic fungus Aspergillus sp.

TL;DR: In this article, tricyclic cyclopiazonic acid (CPA) related alkaloids asperorydines N-P (1,3), together with six known compounds (4,9) were isolated and characterized from the fungus Aspergillus flavus SCSIO F025 derived from the deep-sea sediments of South China Sea.

TL;DR: In this article, six new polyketides, alternaritins A-D [(±)-1−4] and isoxanalteric acid I (8), and 25 known Alternaria toxins were isolated from the culture of an endophytic fungi Alternaria sp.

TL;DR: In this paper, the authors compile current research on the development of coumarins against thrombosis, emphasizing the relationship between their chemical structures and therapeutic effectiveness, and provide promising ideas for the discovery of novel coumarin derivatives with high antithrombotic activity.

TL;DR: In this article, a flavonoid compound, called cynaroside, was used to promote macrophage phenotypic transition from pro-inflammatory M1 to anti-inflammatory m2, and mitigated sepsis-associated liver inflammatory damage.

TL;DR: It was demonstrated that TPD suppressed renal cell carcinoma growth through disrupting NF-κB/COX-2 pathway by targeting ATP-binding sites of IKKβ, and provided pharmacological evidence that T PD exhibits potential use in the treatment of COX- 2-mediated diseases such as ccRCC.

TL;DR: In this paper, three lignans (1, 5 and 6) and two quinic acids (16 and 17) along with 15 known phenylpropanoids were obtained from the ethanol extract of Zanthoxylum nitidum var. tomentosum (Rutaceae), and their structures were confirmed by comprehensive spectroscopic data (NMR and HRESIMS), and the absolute configurations of all novel compounds were elucidated based on electronic circular dichroism (ECD) spectroscopy data.

TL;DR: In this paper, a nanostructured lipid carrier (NLC) was designed to actively target CTD to tumor cells using a hyaluronic acid (HA)-decorated copolymer (mPEG-NH2), which was synthesized using amidation and generated through ultrasonic emulsification in water.

TL;DR: In this article, three novel alkaloids, named oleracone L (1), portulacatone B (2), and Portulacatal (3), were isolated from P. oleracea L and determined using UV, IR, 1D and 2D NMR spectroscopy and UHPLC-ESI-QTOF/MS.

TL;DR: In this paper, the anti-ferroptosis activity of phloroglucinols was investigated in Hypericum japonicum, and the results showed significant inhibitory effect with EC50 of 0.48 ± 0.14μM and 0.94 − 0.6 µm, respectively.

TL;DR: In this paper, four previously undescribed coumarin-homoisoflavonoid derivatives (1, 3, 5, and 6) were isolated from the fruits of C. bisexualis for the first time.

TL;DR: Two new daphnane-type diterpenoids fischerianin A and Fischerianin B (1) and two known ones langduin A (3), as well as two known Diterpenoid A6 (4) were isolated from the extracts of Euphorbia fischeriana Steud dry roots.

TL;DR: In this article, the first investigation of phytochemistry on the seed kernels of Caesalpinia sinensis led to the isolation and characterization of six new compounds including three tricyclic-type cassane diterpenoids (1, 3, 4, 6, 7, 9), together with three know compounds (7, 9).

TL;DR: An innovative method of successive macerations using a mixture of solvents with the aim of simultaneously improving the yield, the partition of the compounds between the different phases and reducing the volume of extractionsolvents is presented.

TL;DR: In this article, an AUF-HPLC-Q-TOF/MS method was employed for screening and characterizing COX-2 ligands from K. coccinea stems for the first time.

TL;DR: In this article, C21-steroidal aglycones (1-9) namely cynotogenins A-I, along with seventeen known analogous (10-26), were isolated from the hydrolysate.

TL;DR: The results of this work indicate that S. marianum wild populations can be composed either of individuals with the same chemotype, or heterogeneous mixtures of individuals characterized by different chemotypes, evidencing a strong genetic control of silymarin biosynthetic pathway.