Showing papers in "Free Radical Biology and Medicine in 2021"

TL;DR: It is demonstrated that ferroptosis was involved in the development of DN, and up-regulating Nrf2 by treating with fenofibrate inhibited diabetes-related ferroPTosis, delaying the progression of DN.

TL;DR: It is concluded that a novel pathway of USP7/p53/TfR1 has been identified in the I/R-treated rat hearts, where up-regulation ofUSP7 promotes ferrptosis via activation of the p53/ TfR 1 pathway.

TL;DR: In this article, the authors investigated the expression of ferroptosis-related proteins in human coronary arteries and analyzed correlation with severity of atherosclerosis and clarified the interactions between proteins and possible mechanisms of atherosis.

TL;DR: In this article, the m6A reader YT521-B homology containing 2 (YTHDC2) has been identified to inhibit lung adenocarcinoma (LUAD) tumorigenesis by suppressing solute carrier 7A11 (SLC7A11)-dependent antioxidant function.

TL;DR: Wang et al. as discussed by the authors found that ADSCs exosomes could polarize macrophage to an anti-inflammatory phenotype via regulating the expression of Nrf2 and HO-1, and improve inflammatory reaction and injury of multi-organ in sepsis.

TL;DR: In this paper, the authors present the already identified senolytics and senomorphics focusing on their redox-sensitive properties and suggest the design of future senotherapeutics to target specific redoxregulated signaling pathways implicated either in the regulation of SASP or in the elimination of SC.

TL;DR: In this article, a combination of molecular and histological methods was used to clarify the mechanism and explore the signaling pathway both in vivo and in vitro models, which suggested that kaempferol might be a novel promising therapeutic agent for SCI.

TL;DR: In this paper, the role of ferroptosis in osteoporosis was investigated in vitro and in vivo, and it was shown that targeting HIF-1α and ferritin in osteoclasts could be an alternative in treatment of bone loss.

TL;DR: In this article, the authors highlight the recent research on mitochondria and synapses in relation to amyloid-beta (Aβ) and P-tau, focusing on recent developments.

TL;DR: In this article, the authors showed that anthocyanins may protect against atherosclerosis and cardiovascular disease through their effects on cellular antioxidant status, oxidative stress, and inflammation; however, their underlying mechanisms of action appear to be complex and require further elucidation.

TL;DR: In this paper, the authors provide an overview of the phosphorylation regulation pattern of NRF2 and discuss the therapeutic potential of interventions targeting NRF 2-like 2 (NRF2)-phosphorylation.

TL;DR: In this paper, the effects of Met on vascular smooth muscle cells (VSMCs) calcification were investigated in a rat aortic tissue and showed that upregulation of POSTN increased the sensitivity of cells to ferroptosis.

TL;DR: The aim of this review is to provide information of the crucial physiological roles of oxidation in the endothelium, vascular smooth muscle cells and perivascular adipose tissue for developing safer and more effective vascular interventions with antioxidants.

TL;DR: The role of myeloperoxidase (MPO) is to generate powerful oxidizing species including hypochlorous acid (HOCl), which is also implicated in host tissue damage and multiple inflammatory diseases.

TL;DR: In this article, the impact of α-tocopherol (αT) and γ-tocoperol-rich tocopherols (γTmT) on colitis-induced colitis in mice was examined.

TL;DR: In this paper, the role of UPRmt in ageing and ageing-related neurodegenerative diseases such as Alzheimer's disease, Huntington's disease and Parkinson's disease is discussed. But, the authors do not consider the effect of the UPRM on the development of heart diseases.

TL;DR: In this article, the authors summarized AGEs/RAGE-mediated oxidative stress and inflammation signaling pathways in diabetic kidney disease and ageing kidney, discussing opportunities and challenges of targeting at AGE-induced oxidative stress that could hold the promising potential approach for improving kidney.

TL;DR: In this paper, the main metabolites accumulating during ischemia in the glucose, fatty acid, and Krebs cycle pathways are discussed and strategies to modulate and counteract the accumulation of substrates that yield ROS and the therapeutic implications of this concept.

TL;DR: A review of the latest literature on these novel mechanisms and intervention strategies with the aim of better understanding the complexities of oxidative stress for more precise targeted therapeutic approaches to prevent cardiac hypertrophy is presented in this paper.

TL;DR: In this article, the authors reviewed the current knowledge about causes and consequences of reactive oxygen species (ROS) in DbCM, as well as the therapeutic potential and strategies of targeting oxidative stress in the diabetic heart.

TL;DR: In this paper, the authors reviewed and discussed the recent literature on the health benefits of tea and its compounds, and specifically explored the molecular mechanisms involved, including the regulation of several classical signaling pathways, such as nuclear factor-κB, AMP activated protein kinase (AMPK), and wingless/integrated (Wnt) signaling.

TL;DR: In this paper, the authors proposed precise mitochondria-targeted therapies aimed at counteracting unregulated ROS production are expected to have therapeutic benefits in certain aging-related heart conditions, however, for an adequate design of such therapies, it is necessary to unravel the complex and dynamic interactions between mitochondria and other cellular processes.

TL;DR: The authors showed that increased necroptosis in the liver contributes to fibrosis in a mouse model of increased oxidative stress and accelerated aging, that also exhibits progressive hepatocellular carcinoma (HCC) development.

TL;DR: In this paper, the expression levels of 125 oxidative stress genes, including 37 pro-oxidant genes, 32 oxidative-responsive genes, and 56 antioxidant genes were found to be upregulated in whole blood and lung autopsies (MPO, S 100A8, S100A9, SRXN1, GCLM, SESN2, and TXN).

TL;DR: In this paper, a systematic literature search was performed in MEDLINE via Pubmed, Web of Science (WOS) core collection, and Virtual Health Library (VHL) via LILACS and IBECS (Spain).

TL;DR: In this paper, the authors tested the hypothesis that 18β-glycyrrhetinic acid (GA), an active compound from medicinal herbal licorice, could induce the production of reactive oxygen species (ROS)/reactive nitrogen species(RNS) and increase lipid peroxidation and trigger ferroptosis in MDA-MB-231 triple negative breast cancer cells.

TL;DR: In this paper, it was shown that Cd-induced ferroptosis depended on endoplasmic reticulum (ER) stress and that inhibition of ER stress reduced the ferrosis caused by Cd.

TL;DR: The molecular mechanisms by which ROS activate AMPK and how AMPK signaling can further prevent heart failure progression are described and the potential therapeutic approaches to target AMPK are reviewed for the treatment of cardiovascular disease and prevention of heart failure.

TL;DR: In this article, the effect of Wedelolactone (Wed) on acute pancreatitis (AP) and lung injury was investigated in the taurocholate or caerulein-induced murine AP model, and it was shown that Wed significantly inhibited caspase1/caspase11 activation, reduced mature interleukin-1β (IL-1α) and Nterminal domain of gasdermin D (GSDMD-N) level.

TL;DR: In this paper, the role of catalase in cancer and the molecular mechanisms associated with the multiple levels of Catalase regulation are discussed. But, the authors focus on the role and the regulation of the enzyme.