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Showing papers in "Gastroenterology in 1999"


Journal ArticleDOI
TL;DR: The outcome of cirrhosis and liver-related death is not uniform across the spectrum of nonalcoholic fatty liver, and poor outcomes are more frequent in patients in whom biopsies show ballooning degeneration and Mallory hyaline or fibrosis.

3,167 citations


Journal ArticleDOI
TL;DR: A consensus-based approach was applied, supplemented by input from international experts who reviewed the report, and a dyspepsia subgroup classification is proposed for research purposes, based on the predominant (most bothersome) symptom.

2,428 citations


Journal ArticleDOI
TL;DR: The establishment of a set of selection criteria for families with hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) to provide a basis for uniformity in collaborative studies and a definition of HNPCC was proposed that was aimed at helping clinicians to identify families.

2,416 citations


Journal ArticleDOI
TL;DR: Two important processes have occurred to legitimize these conditions, and to increase attention toward the research and clinical care of patients with functional gastrointestinal disorders (FGID), a shift in conceptualizing these disorders from a disease-based, reductionistic model, to a more integrated, biopsychosocial model of illness.

2,274 citations


Journal ArticleDOI
TL;DR: Long-term treatment with infliximab showed efficacy and tolerability in managing symptoms of patients with active Crohn's disease not responding to conventional treatments.

1,045 citations


Journal ArticleDOI
TL;DR: The data show for the first time that the prevalence of autoimmune disorders in celiac disease is related to the duration of exposure to gluten.

850 citations


Journal ArticleDOI
TL;DR: In the neonatal period, IL-10 gene-deficient mice have decreased levels of colonic Lactobacillus sp.

750 citations


Journal ArticleDOI
TL;DR: There is now increasing evidence that a number of psychological treatments and antidepressants are helpful in reducing symptoms and other consequences of the FGIDs in children and adults.

735 citations


Journal ArticleDOI
TL;DR: Clinical improvement after infliximab therapy in active Crohn's disease is accompanied by significant healing of endoscopic lesions and disappearance of the mucosal inflammatory infiltrate and architectural changes persisted in most patients.

733 citations


Journal ArticleDOI
TL;DR: The results indicate that a virus-specific CD4(+)/Th1(+) T-cell response that eliminates the virus during the acute phase of disease has to be maintained permanently to achieve long-term control of the virus.

722 citations


Journal ArticleDOI
TL;DR: Ethnic differences in gallbladder disease prevalence differed according to sex and were only partly explained by known risk factors.

Journal ArticleDOI
TL;DR: The value of inclusive rather than restrictive diagnostic criteria that encompass other gastrointestinal and non-gastrointestinal symptoms should be examined to improve the accuracy of symptom-based criteria and reduce the dependence on objective testing.

Journal ArticleDOI
TL;DR: Solid evidence is provided in support of the hypothesis that TNF-alpha plays an important role in the development of early alcohol-induced liver injury via the T NF-R1 pathway through the long-term enteral ethanol feeding technique described for the first time for knockout mice.

Journal ArticleDOI
TL;DR: In adult SBS patients, small bowel length of <100 cm is highly predictive of permanent intestinal failure, and presence of terminal ileum and/or colon in continuity enhances both weaning off PN and survival probabilities.

Journal ArticleDOI
TL;DR: The inflamed colonic mucosa in UC has an impaired barrier function that is much more pronounced than previously assumed and an altered TJ structure contributes to this barrier defect which, because of increased back leak, can reduce net ion transport.

Journal ArticleDOI
TL;DR: Demographically, EGJ-SIM patients are different from patients with Barrett's esophagus and have a higher prevalence of H. pylori infection, which helps to explain the increasing incidence of adenocarcinoma of the distal esphagus and EGJ.

Journal ArticleDOI
TL;DR: This study shows that patients with unexplained hepatic iron overload are characterized by a mild to moderate iron burden and the nearly constant association of an IRS irrespective of liver damage.

Journal ArticleDOI
TL;DR: This article summarizes recent progress and regulatory guidance on design of trials to assess the efficacy of new therapies for functional gastrointestinal disorders (FGIDs).

Journal ArticleDOI
TL;DR: Signs of active inflammation nearly disappear accompanied by a profound down-regulation of mucosal inflammatory mediators in Crohn's ileocolitis after infliximab dramatically decreases histological disease activity.

Journal ArticleDOI
TL;DR: Early measurement of HVPG in cirrhotic patients during acute variceal bleeding provides useful prognostic information on the evolution of the bleeding episode and long-term survival.

Journal ArticleDOI
TL;DR: Rofecoxib, at doses 2-4 times the dose demonstrated to relieve symptoms of osteoarthritis, caused significantly less gastroduodenal ulceration than ibuprofen, with ulcer rates comparable to placebo.

Journal ArticleDOI
TL;DR: In all parts of the world, vacA s1/cagA-positive genotypes were associated with peptic ulcer disease (P < 0.001) and data indicate a geographic distribution of H. pylori genotypes and aid in understanding the relationship of the bacterium with disease.

Journal ArticleDOI
TL;DR: Study of clonal dispersion, during crypt branching morphogenesis or cell migration, shows that mutant progenitors usually partition into only one of the two daughter crypts and that cells are often widely dispersed in spite of the extensive intercellular junctions in the epithelium.

Journal ArticleDOI
TL;DR: Study selection Study designs of evaluations included in the review included: RCTs, controlled multiple crossover, controlled nonrandomized concurrent control, controlledNonrandomized historical control, uncontrolled case series, uncontrolled retrospective caseseries, retrospective casecontrol and uncontrolled prospective.

Journal ArticleDOI
TL;DR: Addition of omeprazole achieves high eradication rates, reduces the impact of primary resistance, and may decrease the risk of secondary resistance compared with regimens containing only two antibiotics.

Journal ArticleDOI
TL;DR: Intact DNA MMR seems to recognize 5-FU incorporated into DNA but may do so in a different manner than other types of alkylation damage, suggesting defective DNA MMR might be one mechanism for tumor resistance to5-FU.

Journal ArticleDOI
TL;DR: iNOS and COX-2 are induced in H. pylori-positive gastritis and thus may modulate the inflammation and alterations in epithelial cell growth that occur in this disease.

Journal ArticleDOI
TL;DR: This literature review and the recommendations therein were prepared for the American Gastroenterological Association Clinical Practice and Practice Economics Committee and following external review, the paper was approved by the committee on May 17, 1998.

Journal ArticleDOI
TL;DR: Investigation of expression of the bile salt export pump in liver samples from patients with a PFIC phenotype and correlated this with BSEP gene mutations shows a close correlation between BSEp gene mutations and canalicular B SEP expression.

Journal ArticleDOI
TL;DR: This literature review and the recommendations therein were prepared for the American Gastroenterological Association Clinical Practice and Practice Economics Committee and were approved by the Committee in March 1999 and by the AGA Governing Board in May 1999.