Showing papers in "Gastroenterology in 2003"

TL;DR: Data suggest that the MELD score is able to accurately predict 3-month mortality among patients with chronic liver disease on the liver waiting list and can be applied for allocation of donor livers.

TL;DR: These guidelines differ from those published in 1997 in several ways: the screening interval for double contrast barium enema has been shortened to 5 years, and colonoscopy is the preferred test for the diagnostic investigation of patients with findings on screening and for screening patients with a family history of hereditary nonpolyposis colorectal cancer.

TL;DR: Hepatocyte apoptosis is significantly increased in patients with NASH and correlates with disease severity, suggesting that antiapoptotic therapy may be useful in this syndrome.

TL;DR: A proinflammatory cytokine genetic profile increases the risk of noncardia gastric adenocarcinoma but not other upper gastrointestinal cancers, possibly by inducing a hypochlorhydric and atrophic response to gastric H. pylori infection.

TL;DR: GPC3 is specifically overexpressed in most HCCs and is elevated in the serum of a large proportion of patients with HCC, suggesting that the simultaneous determination of GPC3 and AFP may significantly increase the sensitivity for diagnosis of HCC.

TL;DR: Based on a prospective randomized trial, CE permits more accurate diagnosis of the extent and severity of the inflammatory activity in UC compared with conventional colonoscopy, and CE with methylene blue is a novel tool for the early detection of IN and CRC in patients with UC.

TL;DR: It is demonstrated that lamivudine treatment for up to 6 years has an excellent safety profile in patients with HBeAg-positive compensated liver disease, but patients with long-standing lamivUDine-resistant mutations may experience worsening liver disease.

TL;DR: Only infliximab was able to bind to PBL and lamina propria T cells and subsequently to induce apoptosis of activated lymphocytes, which may provide a biological basis for the difference in efficacy of the 2 TNF-alpha-neutralizing drugs.

TL;DR: Three years of lamivudine therapy reduces necroinflammatory activity and reverses fibrosis (including cirrhosis) in most patients, therefore, extended-duration YMDD variants may require additional therapies to maintain the histological benefit of treatment.

TL;DR: The gain-of-function mutations of PDGFR alpha appear to play an important role in development of GISTs without KIT mutations.

TL;DR: The hypothesis that insulin resistance may contribute to fibrotic progression in chronic hepatitis C virus infection is supported, and the effect seems to be genotype specific.

TL;DR: Eosinophilic esophagitis, a primary and chronic disease restricted to the esophagus, leads to persistent dysphagia and structural esophageal alterations but does not impact the nutritional state.

TL;DR: CARD15/NOD2 is expressed in intestinal epithelial cells and may serve as a key component of innate mucosal responses to luminal bacteria as an antibacterial factor, which may contribute to the development of Crohn's disease.

TL;DR: The genotype 2a subgenomic replicon was established in Huh7 cells and replicated efficiently with or without G418 selection in a transient replication assay, providing a powerful new tool for researching HCV.

TL;DR: The development of this novel mutation in the HBV polymerase confers resistance to adefovir dipivoxil, and the patient responded to subsequent lamivudine therapy, achieving normalization of alanine aminotransferase and a significant decrease in serum HBV DNA.

TL;DR: In this large, national, population-based study, central adiposity, hyperleptinemia, and hyperinsulinemia were the major determinants of the association of overweight with elevated serum ALT activity.

TL;DR: The role of key loci or genes in IBD pathophysiology are discussed and the importance of genetic variability and its interactions with the immune system, gut microbiota, and environmental factors in determining pathogenesis is highlighted.

TL;DR: In this article, the clinical efficacy and safety of cognitive-behavioral therapy (CBT) against education (EDU) and desipramine (DES) against placebo (PLA) in female patients with moderate to severe functional bowel disorders (irritable bowel syndrome, functional abdominal pain, painful constipation, and unspecified FBD).

TL;DR: The intestinal tropism of the SARS-CoV has major implications on clinical presentation and viral transmission.

TL;DR: It is indicated that increased EC cell counts and depression were equally important predictors of developing PI-IBS (relative risk, 3.8 and 3.2 for each standard deviation increase in respective values).

TL;DR: Oncotic necrosis and apoptosis can share features and mechanisms, which sometimes makes discrimination between the 2 forms of cell death difficult, however, elucidation of critical cell death pathways under clinically relevant conditions will show potentially important therapeutic intervention strategies in hepatic ischemia/reperfusion injury.

TL;DR: In this article, the authors defined the natural course of acute hepatitis C virus infection and contributed to the development of treatment strategies for acute hepatitisC virus infection by using seroconversion to anti-hepatitis C virus antibodies or clinical and biochemical criteria.

TL;DR: In advanced cirrhosis, long-term nutritional supplementation with oral BCAA is useful to prevent progressive hepatic failure and to improve surrogate markers and perceived health status.

TL;DR: Intravenous hydrocortisone premedication significantly reduces ATI levels but does not eliminate ATI formation or infusion reactions, and Administering a second infusion within 8 weeks of the first and concurrent immunosuppressant therapy significantly reduce ATI formation.

TL;DR: The photodynamic therapy (PDT) had a promising effect on nonresectable cholangiocarcinoma (NCC) in patients with NCC as mentioned in this paper.

TL;DR: High-frequency/low-energy gastric electrical stimulation significantly decreased vomiting frequency and gastrointestinal symptoms and improved quality of life in patients with severe gastroparesis.

TL;DR: The N OD2 gene product is most abundant in Paneth cells in the terminal ileum, which could therefore play a critical and hitherto unrecognized role in the pathogenesis of NOD2-associated CD.

TL;DR: It is suggested that HBV carriers with T1762/A1764 basal core promoter mutant are at increased risk for HCC and that this mutant may contribute to the pathogenesis of HBV infection.

TL;DR: Pooled results support a protective association between aspirin and NSAIDs and esophageal cancer (of both histological types) and provide evidence for a dose effect and support evaluating these agents in clinical trials of high-risk patients.