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Showing papers in "Gastroenterology in 2007"


Journal ArticleDOI
TL;DR: A detailed understanding of epidemiologic factors and molecular mechanisms associated with HCC ultimately could improve current concepts for screening and treatment of this disease.

4,768 citations


Journal ArticleDOI
TL;DR: This review focuses on the mechanisms regulating the synthesis, secretion, biological actions, and therapeutic relevance of the incretin peptides glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1).

3,103 citations


Journal ArticleDOI
TL;DR: Aberrant expression of miR-21 can contribute to HCC growth and spread by modulating PTEN expression and PTEN-dependent pathways involved in mediating phenotypic characteristics of cancer cells such as cell growth, migration, and invasion.

2,640 citations


Journal ArticleDOI
TL;DR: Adalimumab was well-tolerated, with a safety profile consistent with previous experience with the drug, and was significantly more effective than placebo in maintaining remission in moderate to severe CD through 56 weeks.

2,028 citations


Journal ArticleDOI
TL;DR: The rapidly expanding body of animal and clinical data that support potential roles for inflammation in the pathogenesis of insulin resistance and type 2 diabetes mellitus are reviewed.

1,670 citations


Journal ArticleDOI
TL;DR: A multidisciplinary task force of 31 physicians assembled with the goal of determining diagnostic criteria and making recommendations for evaluation and treatment of children and adults with suspected eosinophilic esophagitis (EE) provided current recommendations for care of affected patients.

1,513 citations


Journal ArticleDOI
TL;DR: It is likely that a gene-environment interaction, in which genetically susceptible individuals respond to an environment with increased availability of palatable energy-dense foods and reduced opportunities for energy expenditure, contributes to the current high prevalence of obesity.

1,431 citations


Journal ArticleDOI
TL;DR: Serotonin is an important gastrointestinal signaling molecule as mentioned in this paper, which is used by enterochromaffin (EC) cells to activate intrinsic and extrinsic primary afferent neurons to initiate peristaltic and secretory reflexes and transmit information to the central nervous system.

1,268 citations


Journal ArticleDOI
TL;DR: In this paper, the authors identify, isolate, and characterize the CSC population that drives and maintains hepatocellular carcinoma (HCC) growth and metastasis using a severe partial hepatectomy model.

1,147 citations


Journal ArticleDOI
TL;DR: The results were summarized in a draft manuscript by the primary authors (G.D. and W.J. as discussed by the authors ) and discussed at the annual IOIBD meetings in 2004 and 2005.

1,064 citations


Journal ArticleDOI
TL;DR: The present results give further strength to the use of mucosal healing as a clinical indicator and treatment goal in inflammatory bowel disease.

Journal ArticleDOI
TL;DR: The study showed that fecal microbiota is significantly altered in IBS, and further studies on molecular mechanisms underlying these alterations are needed to elucidate the exact role of intestinal bacteria in the syndrome.

Journal ArticleDOI
TL;DR: HVPG, MELD, and albumin independently predict clinical decompensation in patients with compensated cirrhosis and with portal hypertension as determined by the hepatic venous pressure gradient.

Journal ArticleDOI
TL;DR: The rigorously developed Pediatric Ulcerative Colitis Activity Index is a noninvasive, valid, highly reliable, and responsive index with which to assess disease activity in pediatric ulcerative colitis.

Journal ArticleDOI
TL;DR: Pediatric patients responding to an induction regimen of infliximab were more likely to be in clinical response and remission at week 54 without dose adjustment when their maintenance therapy was given every 8 weeks rather than every 12 weeks.

Journal ArticleDOI
TL;DR: Increased CD4(+)CD25(+)FoxP3(%) Treg may impair the effector function of CD8(+) T cells, promote disease progression, and represent both a potential prognostic marker and a therapeutic target for HBV-related HCC individuals.

Journal ArticleDOI
TL;DR: The probiotic bacterium Lactobacillus rhamnosus GG and factors recovered from LGG broth culture supernatant (LGG-s) prevent cytokine-induced apoptosis in human and mouse intestinal epithelial cells by regulating signaling pathways as mentioned in this paper.

Journal ArticleDOI
TL;DR: HULC is the first ncRNA with highly specific up-regulation in HCC, suggesting a role for HULC in post-transcriptional modulation of gene expression.

Journal ArticleDOI
TL;DR: The severity of microscopic inflammation over time is an independent risk factor for developing advanced colorectal neoplasia among patients with long-standing UC.

Journal ArticleDOI
TL;DR: Mucosal mast cell mediators from IBS patients excite rat nociceptive visceral sensory nerves in vitro, providing new insights into the mechanism underlying visceral hypersensitivity in IBS.

Journal ArticleDOI
TL;DR: The effects of dietary and bacterial eradication therapy on disease progression and lesion reversibility are reviewed within the context of population studies and compared between study designs and populations tested.

Journal ArticleDOI
TL;DR: Resistant HCV isolates are selected rapidly during therapy with the highly active protease inhibitor telaprevir, and changes in the frequency of mutations after the end of dosing showed an inverse relationship between in vivo viral fitness and resistance.

Journal ArticleDOI
TL;DR: Forsmark et al. as mentioned in this paper presented a study of Gastroenterologia, Hepatologia and Nutricion at the University of Florida Gainesville, Florida.

Journal ArticleDOI
TL;DR: Data from in vitro and ex vivo models of intestinal epithelial cells revealed that TLR2 stimulation effectively preserves TJ-associated barrier assembly against stress-induced damage through promotion of PI3K/Akt-mediated cell survival via MyD88.


Journal ArticleDOI
TL;DR: Patients with a new diagnosis of right-sided, transverse, splenic flexure/descending, rectal or sigmoid CRC in Ontario from April 1, 1997 to March 31, 2002 who had a colonoscopy within the 3 years before their diagnosis are advised to inform patients of the small risk of these cancers after Colonoscopy.

Journal ArticleDOI
TL;DR: Response and remission rates for natalizumab were superior to those for placebo at Weeks 4, 8, and 12, demonstrating the early and sustained efficacy of natalIZumab as induction therapy in patients with elevated C-reactive protein and active Crohn's disease.

Journal ArticleDOI
TL;DR: Patients with D-IBS display enhanced proinflammatory cytokine release, and this may be associated with symptoms and anxiety, and the results suggest that LPS-induced TNF-alpha production was associated significantly (r = 0.59, P < .001) with anxiety in patients with IBS.

Journal ArticleDOI
TL;DR: The hypothesis that Toll-like receptor 4 (TLR4) is involved in tumorigenesis in the setting of chronic inflammation is tested and it is shown that TLR4 is overexpressed in human and murine inflammation-associated colorectal neoplasia and inhibition of TLR 4 signaling may be useful in the prevention or treatment of colitis-associated cancer.

Journal ArticleDOI
TL;DR: In this paper, the authors showed that primary prophylaxis with norfloxacin has a great impact in the clinical course of patients with advanced cirrhosis, reducing the incidence of spontaneous bacterial peritonitis, delaying the development of hepatorenal syndrome, and improving survival.