Showing papers in "Gene in 2013"

TL;DR: The overall function of alternative splicing is to increase the diversity of mRNAs expressed from the genome as mentioned in this paper, which can have profound functional effects, such as increasing cell proliferation, cell survival and properties of the nervous system.

TL;DR: A historical view is taken and some of the milestones that had an important impact on the development of gene therapy are highlighted and some concerns that have been connected with gene therapy as an important therapeutic modality are addressed.

TL;DR: This review discusses recent significant advances in studying the physiological functions of key MAPK transcriptional targets and focuses on the mechanisms by which MAPKs are targeted to the nucleus and chromatin, and how they impact on chromatin structure and subsequent gene regulation.

TL;DR: The mechanisms by which MIR155HG expression can be regulated are summarized and it is suggested that it may be possible to therapeutically attenuate miR-155-5p levels in the treatment of several pathological processes.

TL;DR: Several biochemical mediators involved in OA and pain are explored, and a framework for the understanding of potential biologic therapies in the treatment of degenerative joint disease in the future is provided.

TL;DR: Mammalian soluble epoxide hydrolase contributes to the regulation of vascular tone, nociception, angiogenesis and the inflammatory response and is being investigated as a therapeutic target.

TL;DR: Current state of the art concerning microbubble-cell interactions and cellular effects leading to sonoporation and its application for gene delivery are summarized.

TL;DR: This paper expands on the specific impact of mitochondrial genetic change and production of free radicals as well as its correlation to the neurodegeneration in Parkinson's disease.

TL;DR: A miRNA signature characterizing the osteogenic differentiation of MSCs is defined and evidence for the involvement of miR-31 in the regulation of the bone-specific transcription factor Osterix is provided.

TL;DR: The exceptional value of RMCE emerged after its entry into the stem cell field, where it started to contribute to the generation of induced pluripotent stem (iPS-) cells and their subsequent differentiation yielding a variety of cell types for diagnostic and therapeutic purposes.

TL;DR: The DiffCorr package is developed, a simple method for identifying pattern changes between 2 experimental conditions in correlation networks which builds on a commonly used association measure, such as Pearson's correlation coefficient, and is suitable for the first step towards inferring causal relationships and detecting biomarker candidates.

TL;DR: The progress made in the gene therapy trials targeting ADA-SCID, SCID-X1, CGD and WAS is summarized, the pitfalls are reviewed, and the recent advancements are outlined which are expected to further enhance favourable risk benefit ratios for gene therapeutic approaches in the future.

TL;DR: MiR-195 and miR-378 are abnormally expressed and epigenetically regulated in gastric cancer cell lines and tissues via the suppression of CDK6 and VEGF signaling, suggesting that miR's have tumor suppressor properties in Gastric cancer.

TL;DR: This review gives an overview of retroelement insertions in genes that cause significant changes in their transcription and cotranscriptional splicing and show a remarkable level of complexity.

TL;DR: This study demonstrates that altered miRNA expression pattern is involved in acquiring resistance to Adr and Doc in breast cancer MCF-7 cells, and that there are some miRNAs who displayed consistent up- or down-regulated expression changes in the two resistant sublines.

TL;DR: The results show that the expression change of miRNAs and their targets were dose-dependent and tissue-dependent under salinity and drought conditions, and the expression of mi RNAs in leaf was down-regulated under higher salinity stress while shows variable patterns in other conditions.

TL;DR: Though some mutations clearly dampened protein expression, deletion of amino acids 57-70, corresponding to the predicted 3rd alpha helix of α-mating factor secretion signal, increased secretion of reporter proteins horseradish peroxidase and lipase at least 50% in small-scale cultures, raising the possibility that the secretory efficiency of the leader can be further enhanced in the future.

TL;DR: An overview on the production of GM crops, their acceptabilities, detection strategies, biosafety issues and potential impact on society is presented and overall future prospects are also highlighted.

TL;DR: Results showed that for RT-qPCR analysis of tilapia, selecting two or more reference genes may be more suitable for cross-tissue analysis of gene expression.

TL;DR: The findings suggest that the HMGB1-TLR4 axis plays a pathogenic role in triggering cardiomyocyte apoptosis during myocardial I/R injury and that the possible mechanism for this process is the result of released cytokines and inflammatory response involved in theHMGB1/ TLR4-related pathway.

TL;DR: High prevalence of resistance in Vallée du Kou to pyrethroids, DDT and dieldrin, moderate level for carbamates and full susceptibility to organophosphates is detected, highlighting the complex network of mechanisms conferring multiple resistance in malaria vectors.

TL;DR: The adiponectin gene variants and haplotype contribute to the genetic risk towards the development of type 2 diabetes, obesity and hypoadiponectinemia in the south Indian population.

TL;DR: To systemically evaluate the most frequently reported cancers in which miR-183 family members were up- or down-regulated is critical for further investigation on physiological impact of its aberrant regulation in specific cancers.

TL;DR: The results implied that SA temporally regulated the transcript levels of the genes encoding ASA-GSH cycle enzymes, resulting in the increased contents of GSH and ASA and enhanced salt tolerance.

TL;DR: Present investigation suggests the effectiveness of SCoT marker system to estimate the genetic diversity of D. nobile and that it can be seen as a preliminary point for future research on the population and evolutionary genetics of this endangered orchid species of medicinal importance.

TL;DR: Disease inoculation experiments with mutants of the AtROBH genes showed that AtRRobHD and AtRobHF have opposite effects on disease development and provided new insights into the functions of the genes encoding NADPH oxidase in fungal disease resistance.

TL;DR: A comprehensive evolutionary analysis of the BBX protein family in twelve plant species showed that the B-box consensus sequences of each structure groups retained a common and conserved domain topology, and identified seven novel motifs specific to each structure group and a valine-proline pair conserved at the C-terminus domain suggesting that they are required for protein-protein interactions.

TL;DR: Comparison of gene expression among salt, saline-alkali and drought treated plants revealed that genes associated with calcium-signaling and nucleic acid pathways were up-regulated in the responses to all three stresses, indicating a degree of cross-talk among these pathways.

TL;DR: The goal of this review is to present an update of the main genetic and molecular mechanisms, as well as the associated phenotypes of cardiac channelopathies as of 2012.

TL;DR: Overexpression of GmERF7 in tobacco plants led to higher levels of chlorophyll and soluble carbohydrates and a lower level of malondialdehyde compared with wild-type tobacco plants under salt stress conditions, which indicated that Gm ERF7 enhanced salt tolerance in transgenic plants.