Showing papers in "Gynecologic Oncology in 2010"

TL;DR: This review summarizes the available clinicopathological data on uterine sarcomas classified by the WHO diagnostic criteria and concludes that immunohistochemical studies of oncoproteins as well as molecular analysis of non-random translocations will lead to an accurate and prognostically relevant classification of these rare tumors.

TL;DR: HPV DNA testing has been shown consistently to be superior to cytology in terms of sensitivity and positive predictive value and will become a major tool in cervical cancer screening, at least in the developed countries.

TL;DR: It is found that metformin is a potent inhibitor of cell proliferation in endometrial cancer cell lines, partially mediated through AMPK activation and subsequent inhibition of the mTOR pathway.

TL;DR: A high correlation of miRNA expression level was found between breast tumor tissues and sera and should encourage further studies on the use of miRNAs in serum samples as an easy and convenient method of breast cancer screening.

TL;DR: Recent studies in a mouse cervicovaginal challenge model indicate that, surprisingly, the virus cannot initially bind to keratinocytes in vivo, rather it must first bind via its L1 major capsid protein to heparan sulfate proteoglycans (HSPGs) on segments of the basement membrane exposed after epithelial trauma.

TL;DR: Trastuzumab as a single agent did not demonstrate activity against endometrial carcinomas with HER2 overexpression or HER2 amplification, although full planned accrual of women with Her2 amplified tumors was not achieved due to slow recruitment.

TL;DR: The purpose of this review was to give an overview of the current knowledge on adenocarcinoma of the cervix and its differences from squamous cell carcinoma with regard to risk factors, prognosis, survival rates, patterns of recurrence, and response to treatment.

TL;DR: Pazopanib monotherapy was relatively well tolerated, with toxicity similar to other small-molecule, oral angiogenesis inhibitors, and demonstrated promising single-agent activity in patients with recurrent ovarian cancer.

TL;DR: Analysis of ovarian cancer tissues suggests that ovarian surface cells acquire a more epithelial miR-200-ZEB1/2 phenotype as they undergo transformation, suggesting the mesothelial-to-epithelial (Meso-E-T) model for development of ovarian cancers that arise from ovariansurface cells, as has been proposed previously on the basis of studies of protein markers.

TL;DR: Hospital ovarian cancer surgical volume >or=21 cases/year is associated with a higher likelihood of patients with Stage IIIC/IV epithelial ovarian cancer receiving standard treatment (surgery followed by adjuvant chemotherapy) and is significantly predictive of improved overall survival outcome.

TL;DR: PET/CT is superior to pelvis US, abdomino-pelvic CT, and pelvic MRI for diagnosis of malignant ovarian tumors and is useful in revealing metastatic ovarian cancer and co-existing malignant tumors.

TL;DR: Adjuvant radiation therapy should be avoided in patients who undergo systematic lymphadenectomy if an alternative postoperative strategy is possible and elimination of CINDEIN dissection may be helpful in reducing the incidence of POLEL.

TL;DR: The deregulation of miR-27a may be involved in the development of drug resistance, regulating the expression of MDR1/P-gp, at least in part, by targeting HIPK2 in ovarian cancer cells.

TL;DR: Rates of major morbidity and mortality following EUAS for primary cytoreduction were 22% and 1.4%, respectively, which appears acceptable in a cohort of patients with a large tumor burden.

TL;DR: Since up to 89% patients with early-stage disease have symptoms prior to diagnosis, increased awareness of the medical community may facilitate further workup in patients who otherwise would have had a delay, according to this commentary.

TL;DR: The findings serve to advance the development of blood-based screening methods for the discrimination of benign and malignant ovarian masses by confirming and expanding upon the superior utility of the CA-125/HE4 combination.

TL;DR: Effective immunotherapy must combine immune-activating strategies with elimination of immune-suppressing mechanisms, and it is believed that tilting the balance from animmune-suppressive to an immune-active environment may have an enormous impact on the disease.

TL;DR: Among patients with advanced or recurrent endometrial cancer, complete cytoreduction to no gross residual disease is associated with superior overall survival outcome, and the unexpected correlation between treatment modality and survival is suggested.

TL;DR: A simple index based on five prognostic factors may have utility in clinical practice to identify the women who are not likely to respond to the cisplatin-containing regimens and should be considered for non-cisplatin chemotherapy or investigational trials.

TL;DR: In this article, a retrospective analysis of women who underwent robotic radical hysterectomy (RRH) from 2005 to 2008 was performed to assess progression-free and overall survival (OS) for women with cervical cancer.

TL;DR: A 2-of-3-positive decision rule yields acceptable specificity, and higher sensitivity when all 3 tests are performed than when the SI is used to select women for screening by CA125 and HE4.

TL;DR: Robotic-assisted surgery is an acceptable alternative to laparoscopy for minimally invasive staging of endometrial cancer in addition to the improved ease of operation, visualization, and range of motion of the robotic instruments, robotic surgery results in a lower mean blood loss, although longer operative time.

TL;DR: Sentinel lymph node biopsy in early cervical cancer is a more sensitive procedure in detecting pelvic lymph node metastases compared to complete lymphadenectomy.

TL;DR: Current controversies in surgical staging for endometrial cancer are reflected in the practice patterns among gynecologic oncologists, and it is unclear if standardizing surgical practice patterns will improve outcomes for patients with endometricrial cancer.

TL;DR: Measurements of mood, distress, sexual function, and QOL did not differ significantly by surgical type, and instead reflect the challenges faced by young cervical cancer patients treated by RT or RH without adjuvant treatment.

TL;DR: Although the quadrivalent HPV vaccine has been shown to be effective and safe in men, low awareness of HPV in males may be a barrier to its use for the prevention of HPV infection.

TL;DR: Women with CCC-O have a 2.5-times greater risk of disease related VTE than women with other histologies of epithelial ovarian cancer despite adherence to prophylactic guidelines, and one should consider indefinite therapeutic anticoagulation in women with C CC-O.

TL;DR: The data suggest that six rather than three cycles of chemotherapy may decrease the recurrence of patients with serous tumors, and further studies are needed to confirm these findings.

TL;DR: Type is more reproducibly assigned than grade and identifies a larger cohort of women with stage I/II ovarian carcinoma with favorable outcomes (12.2% vs. 6.5%), and therefore is superior to grade in estimating risk of death from ovarian carcinomas.

TL;DR: RVT is now well established as a safe and feasible procedure for this patient population, with low morbidity, recurrence, and mortality rates, and RAT in selected patients has increased.