Showing papers in "Heart Rhythm in 2005"

TL;DR: The present report elaborates further on the diagnostic criteria and examines risk stratification schemes and device and pharmacological approaches to therapy on the basis of the available clinical and basic science data.

TL;DR: In this comprehensive cardiac channel gene screen of the largest cohort of consecutive, unrelated patients referred for LQTS genetic testing, half of the patients had an identifiable mutation.

TL;DR: The data demonstrate triggered firing within canine pulmonary veins with combined parasympathetic and sympathetic nerve stimulation, suggesting both an enhanced Ca transient and increased Na/Ca exchange may be required for arrhythmia formation.

TL;DR: Most physicians, including many cardiologists, cannot accurately calculate a QTc and cannot correctly identify a long QT.

TL;DR: The most common cause of sudden, natural death in young adults is arrhythmia as mentioned in this paper, which is the most commonly reported cause of death in those with no or minimal structural heart disease.

TL;DR: These results suggest, but do not prove, a causal relationship between frequent RV pacing and adverse outcomes in patients with left ventricular ejection fraction < or = 40%.

TL;DR: Macroreentrant AT is a common form of proarrhythmia after LA circumferential ablation for AF and because it may resolve spontaneously, ablation of AT should be deferred for several months.

TL;DR: In order to minimize periprocedural permanentpacemaker effusions, temporary pacemaker placement should be avoided unless essential, and particular care should be taken when placing a permanent pacemaker in patients who are taking steroids.

TL;DR: The salient properties of cardiac I(K1) are described and the role of this current in the cardiac action potential and in underlying regional differences in cardiac excitability are discussed.

TL;DR: The feasibility of fusion of multislice computed tomography with electroanatomic mapping to guide radiofrequency catheter ablation of atrial arrhythmias is studied and it is found that MSCT images can be fused with the three-dimensional electroan atomic mapping system in an accurate manner.

TL;DR: Although some clinical features may predict the need for system modification, additional studies are needed to better define "acceptable efficacy" of ICDs in preventing sudden death prior to altering these standards in selected patients.

TL;DR: Detecting drug-induced augmentation of TRIaD may offer an additional, more sensitive, and accurate indicator of the broader proarrhythmic potential of a drug than may QT interval prolongation alone.

TL;DR: Symptoms of atrial fibrillation often were not associated with documented atrial tachyarrhythmias, and more than 90% of atrian tachy arrhythias were clinically silent.

TL;DR: Recent advances that have improved understanding of mechanisms, particularly the role of transmural dispersion of repolarization, in the genesis of drug-induced TdP are reviewed to examine how these advances can guide the development of safer and more effective drugs.

TL;DR: Spatial QRS-T angle is a significant and independent predictor of cardiovascular mortality that provides greater prognostic discrimination than any of the commonly utilized ECG diagnostic classifications.

TL;DR: The authors' data demonstrate disparate response of Brugada patients to flecainide and ajmaline, with a failure of fle cainide in 7 of 22 cases (32%).

TL;DR: This study demonstrates that ECGI can capture important features of cardiac electrical excitation in humans noninvasively during a single beat and shows that general excitation patterns and electrogram morphologies are largely preserved in open chest conditions.

TL;DR: Findings suggest that CPVT may be underrecognized among physicians referring patients because of a suspected channelopathy, and a diagnosis of "atypical LQTS" may warrant consideration of CPVT and analysis of RyR2 if the standard cardiac channel gene screen for LQ TS is negative.

TL;DR: During medium-term follow-up, restoration of sinus rhythm by LACA results in partial return of LA function in patients with chronic AF, however, in Patients with paroxysmal AF, LA catheter ablation results in decreased LA function.

TL;DR: There are significant changes in LA-PV anatomy with respiration and MR images acquired during standard held inspiration may introduce unnecessary errors in registration during image-guided intervention.

TL;DR: QT and related ECG intervals are heritable traits in a large unselected population and suggestive evidence for a quantitative trait locus on chromosome 3 influencing QT interval duration is provided.

TL;DR: Resynchronization therapy through a coronary vein improves acute hemodynamic function of heart failure patients with LV conduction disorder and overall there were no group differences in hemodynamic effects among different stimulation sites within a coronary veins.

TL;DR: In patients with advanced heart failure undergoing cardiac resynchronization therapy, LV hemodynamics may be further improved by optimizing LV-RV delay, and the optimal VV interval could not be predicted by any clinical nor echocardiographic parameter.

TL;DR: In patients with difficult to induce or nonsustained VT with the typical right bundle branch block pattern and a superiorly directed axis on 12-lead ECG, RF energy ablation delivered in a linear fashion approximately midway to two thirds toward the apex along the mid to inferior septum and perpendicular to the plane of the sePTum is safe and effective for VT control.

TL;DR: It is suggested that not only the transmural gradients but also the apicobasal repolarization gradients contribute to genesis of the T wave.

TL;DR: The majority of common human SCN5A polymorphisms have a distinct molecular phenotype that depends upon the splice variant background, and these findings have implications for the interpretation of previous studies of arrhythmia mutations.

TL;DR: HRC are noninvasively monitored physiomarkers that identify infants in the NICU who are at high risk for sepsis, UTI, and death for infants stratified by HRC measurements.

TL;DR: Patients who meet task force criteria for ARVD are at high risk for sudden cardiac death and should undergo ICD placement for primary and secondary prevention, regardless of electrophysiologic testing results.

TL;DR: With the exception of NYHA class, patients with RBBB as the qualifying wide QRS did not derive significant benefit from CRT in any of the other parameters studied at 3 or 6 months, consistent with a placebo effect.

TL;DR: Paced QRS duration is a significant, independent predictor of heart failure hospitalization in patients with sinus node dysfunction and a very long paced QRSduration is associated with increased heart failureospitalization.