Showing papers in "Heart Rhythm in 2007"

TL;DR: LV dysfunction in the setting of frequent, idiopathic PVCs may represent a form of cardiomyopathy that can be reversed by catheter ablation of the PVCs.

TL;DR: Blebbistatin is a promising novel selective excitation-contraction uncoupler that can be used for optical imaging of cardiac tissues.

TL;DR: The fQRS is an independent predictor of cardiac events in patients with CAD and is associated with significantly lower event-free survival for a cardiac event on long-term follow-up.

TL;DR: This statement examines the relation of the resting ECG to its technology to establish standards that will improve the accuracy and usefulness of the ECG in practice and recommend recommendations for ECG standards.

TL;DR: Atrial fibrosis appears to play a role in the development of a vulnerable substrate for AF, especially in the setting of CHF, as well as angiotensin and Transforming growth factor-beta, which appear to play an important role.

TL;DR: T(p-e) does not correlate with transmural dispersion of repolarization but is an index of total dispersion, which means that parts of the heart fully repolarize before the moment of T(peak) in the T wave of the ECG.

TL;DR: Tpeak-Tend is more valuable than QTc and QT dispersion as a predictor of TdP in patients with acquired LQTS and changes in this parameter are thought to be capable of reflecting changes in spatial dispersion of repolarization, particularly TDR, and thus may be prognostic of arrhythmic risk under a variety of conditions.

TL;DR: This study provides the first molecular and functional evidence implicating CAV3 as a pathogenic basis of SIDS and shows that the LQT3-like phenotype of increased late sodium current supports an arrhythmogenic mechanism for some cases of Sids.

TL;DR: This guide updates an earlier version published in 2000, reviews indications for use of amiodarone and recommends strategies to minimize adverse effects, based on the best available data and the collective experience of the member of the writing committee.

TL;DR: The Sprint Fidelis high-voltage lead appears to be prone to early failure and its use should be limited until the failure mechanism is identified and corrected.

TL;DR: Early complications of pulmonary vein catheter ablation seem to be fewer than in the early years of AF ablation, but still occur in 3.9% of procedures.

TL;DR: Postinfarction patients with severe left ventricular dysfunction in whom electrical storm developed have significantly higher mortality than patients with only isolated VT/VF as well as those without any episodes of VT/VB, and patients who experienced postenrollment ventricular arrhythmias and/or interim coronary events during follow-up were at higher risk for VT/F storms.

TL;DR: It is demonstrated that spontaneous (voltage-independent) sarcoplasmic reticulum calcium release underlies the mechanisms of focal discharges in canine models of PAF induced by electrical, structural, and neural remodeling.

TL;DR: Isoproterenol infusion was effective as an acute treatment in suppressing electrical storm of VF and was successfully replaced with chronic oral medications.

TL;DR: A novel pathogenic mechanism for SIDS is reported, whereby SIDS-linked RyR2 mutations alter the response of the channels to sympathetic nervous system stimulation such that during stress the channels become "leaky" and thus potentially trigger fatal cardiac arrhythmias.

TL;DR: Idiopathic VT/PVCs arising from tricuspid annulus are not rare, and the detailed origin can be determined by ECG analysis, as well as radiofrequency catheter ablation.

TL;DR: ECG features distinguishing epicardial LV-VT are site specific, including the presence or absence of a Q wave in leads that reflect local ventricular activation, according to region specific ECG criteria.

TL;DR: LF power reflects baroreflex function, not cardiac sympathetic innervation, and is unrelated to myocardial 6-[(18)F] fluorodopamine-derived radioactivity or cardiac norepinephrine spillover.

TL;DR: The hypothesis that amplification of spatial dispolarization in the form of transmural dispersion of repolarization (TDR) underlies the development of life-threatening ventricular arrhythmias associated with inherited ion channelopathies, including the long QT, shortQT, and Brugada syndromes as well as catecholaminergic polymorphic ventricular tachycardia, is examined.

TL;DR: Preliminary evidence suggests that beta-blockers and calcium blockers could be better than beta- blockers alone for preventing exercise-induced arrhythmias in CPVT.

TL;DR: In cardiac sarcoidosis patients, CAVB develops mainly during the active phase of the disease, and early treatment with corticosteroids might improve AV conduction disturbance.

TL;DR: In aging human atrial bundles stimulated from only a single site, premature stimuli induce variable arrhythmogenic conduction responses that are greatly enhanced by remodeling of cellular connectivity during aging.

TL;DR: Two new styryl voltage-sensitive dyes with excitation/emission wavelengths shifted >100 nm to the red are synthesized and characterized and are optimized for deeper tissue probing and optical mapping of blood-perfused tissue and intramural optical mapping.

TL;DR: Functional evidence for the interconnections between ganglionated plexi to modulate sinus and AV nodal function is provided, supporting clinical evidence that interConnections within the intrinsic cardiac ANS are critical elements in identifying the targets for atrial fibrillation ablation.

TL;DR: LV transseptal endocardial lead implantation from the pectoral area is a feasible approach in patients with a failed CS approach and in whom epicardial surgical lead placement is not an option.

TL;DR: In this article, a consensus statement summarizes the current understanding of sudden cardiac arrest in young athletes, defines the necessary elements for emergency preparedness, and establishes uniform treatment protocols for the management of SCA.

TL;DR: The heritability of AF in the general population is strongly supported by population-based data and genetic epidemiological studies on AF can potentially yield important mechanistic insights that may ultimately lead to novel preventative and therapeutic strategies.

TL;DR: Overall pulse generator performance was satisfactory and major adverse clinical events due to pulse generator end-of-service life behavior were related to electronic and connector defects, and both normal and severe battery depletion.

TL;DR: The initial experience with a novel software algorithm designed to automatically detect CFAEs was reported to report a strong trend toward more highly repetitive CFAE sites located at the PV ostia in patients with paroxysmal AF compared with persistent AF patients.