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JournalISSN: 0018-019X

Helvetica Chimica Acta 

About: Helvetica Chimica Acta is an academic journal. The journal publishes majorly in the area(s): Bicyclic molecule & Cycloaddition. It has an ISSN identifier of 0018-019X. Over the lifetime, 22303 publication(s) have been published receiving 413097 citation(s).
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Journal ArticleDOI
Abstract: For the characterization of organic substances in gas chromatography a number termed «retention index» is proposed. A simple relation exists between the retention index of a compound on a non-polar stationary phase and its boiling point.

1,820 citations


BookDOI
TL;DR: The start: platinum complexes for the treatment of cancer - why the search goes on and new developments: structure-activity relationships within di- and trinuclear platinum phase I clinical anticancer agents the development of orally-active platinum drugs methods for screening the potential antitumor activity of platinum compounds in combinatorial libraries computational studies on platinum antitumors complexes and their adducts with nucleid acids constituents.
Abstract: Part I The start: platinum complexes for the treatment of cancer - why the search goes on Part II Cisplatin - how good is it?: clinical status of cisplatin and other PT antitumor drugs Part III How does it possibly work? - biochemistry: the response of cellular proteins to cisplatin - damaged DNA the mechanism of action of cisplatin - from adducts to apoptosis replication of platinated DNA and its mutagenic consequences interstand cross-links in cisplatin- or transplatin-modified DNA Part IV Chemistry relevant to PT-biomolecule interactions: platinum complexes - hydrolysis and binding to N7 and N1 of purines reactivity and inertness of PT-nucleobase complexes kinetics and selectivity of DNA platination structure and dynamics of PT anticancer drug adducts from nucleotides to oligonucleotides as revealed by NMR methods 195Pt and 15N NMR spectroscopic studies of cisplatin reactions with biomolecules structural aspects of PT-purine interactions - from models to DNA platinum-sulfur interactions involved in antitumor drugs, rescue agents and biomolecules diammine- and diamineplatinum complexes with non-sulfur-containing amino acids and peptides Part V Inorganic chemistry revived or initiated by cisplatin: platinum blues - on the way toward unraveling a mystery heteronuclear PT(II) complexes with pyrimidine nucleobases displatinum(III) complexes - chemical species more widely spread than suspected inorganic and organometallic chemistry of cisplatin-derived PT(III) complexes Part VI New developments: structure-activity relationships within di- and trinuclear platinum phase I clinical anticancer agents the development of orally-active platinum drugs methods for screening the potential antitumor activity of platinum compounds in combinatorial libraries computational studies on platinum antitumor complexes and their adducts with nucleid acids constituents

1,319 citations



Journal ArticleDOI
H. Lindlar1Institutions (1)
Abstract: Es wird die Darstellung eines Palladium-Blei-Katalysators und seine Anwendung fur einige Partialhydrierungen unter Erhaltung aliphatischer Doppelbindungen beschrieben.

929 citations


Journal ArticleDOI
Abstract: Four new iridoid glucosides 1–4, named blumeosides A–D, were isolated from the methanolic stem-bark extract of Fagraea blumei G. DON. (Loganiaceae). They were accompanied by the benzyl-alcohol derivative di-O-methylcrenatin (5) and the flavone C-glucoside swertisin (6). The structures of 1–4 were established by spectroscopic methods, including FAB-MS, and 1H- and 13C-NMR, and by alkaline hydrolysis. Blumeosides A (1) and C (3) are 10-O-(2,5-dihydroxytercphthalo) adoxosidic acid and 10-O-(2-hydroxyterephthalo)adoxosidic acid, respectively. In blumeosides B (4) and D (2), both carboxylic groups of the terephthalic-acid moiety are esterified by adoxosidic-acid units, Blumeosides A–D (1–4) inhibited bleaching of crocin induced by alkoxyl radicals. Blumeosides A (1) and D (2) also demonstrated scavenging properties towards the 2,2-diphenyl-1-picryl-hvdrazvl (CDPPH) radical in TLC autographic and spectrophotometric assays.

708 citations


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Performance
Metrics
No. of papers from the Journal in previous years
YearPapers
202186
202051
201987
201855
201745
2016131