Showing papers in "Hematology, Transfusion and Cell Therapy in 2019"

TL;DR: This study standardized a closed system protocol which can be utilized for clinical grade stem cell derivation, and detailed characterization of human adipose tissue-derived mesenchymal stem cells, their genomic stability and differentiation potential from stromal vascular fraction of human fat tissue would help assist in tissue regeneration and repair.

TL;DR: The platelet indices, mainly the MPV and PDW, which are economical and easily available, can be reliable in the prediction and early diagnosis of preeclampsia, as well as a marker for the severity of preeClampsia.

TL;DR: The main pharmacological properties and clinical outcomes of new proteasome inhibitors are summarized, and their potential to change the whole multiple myeloma therapeutic landscape is discussed.

TL;DR: It is not likely that targeting a single pathway will result in long-term disease control in older patients with acute myeloid leukemia, and the use of combined therapy to block resistance mechanisms and enhance apoptosis is recommended.

TL;DR: Even with the reduction in HBV, the increased rate of syphilis may have contributed to the fact that the overall rate of TTIs did not decrease in the evaluated period.

TL;DR: The reproducibility of the PLASMIC score was quite satisfactory in the sample and accurately discriminates between patients who had ADAMTS13 deficiency and those with normal enzyme activity, precluding the need for specific laboratory evaluation, which is not always available.

TL;DR: A high prevalence rate of HCV in subjects with transfusion-dependent thalassemia is linked with insufficient facilities, poor management and compromised socioeconomic status and more multicenter studies covering cities from different regions of the country are needed in order to develop preventive measurements at the regional and national level.

TL;DR: Under the authors' conditions the thrombin generation test seems to be sensitive to evaluation of hyper/hypocoagulability states and may have an application in the evaluation of bleeding and thrombotic disorders.

TL;DR: The PCR-SSP was more economical compared to other methods, and the serological method was faster than the molecular methods, however, all methods proved to be effective and safe in the detection of erythrocyte antigens.

TL;DR: Data differing from those classically expected at diagnosis of acute lymphoblastic leukemia in children were documented in a cohort of Hispanic children over one decade with a wide spectrum of complete blood count abnormalities, forms of presentation and frequency of physical findings.

TL;DR: Recommendations are made on how the transmission of T. cruzi can be avoided through the implementation of better diagnostic and pathogen control measures at blood banks.

TL;DR: Hemophilia had a higher negative impact upon the physical, sports and leisure features in the sample subjects and the Haem-A-Qol is considered the most recommended to evaluate the Qol, as it addresses factors more specifically related to the disease.

TL;DR: The creatinine level, ferritin and IL-6 can be used to predict the hepcidin level in patients with anemia of chronic disease, and it is to be hoped that further cohort studies can validate the formula to predict this level.

TL;DR: This study showed comparable reference intervals for platelet indices, using the Sysmex XN-10, with the previous literature, which will allow for low and high values to be facilitated in order to do further research and guide platelet disorder management.

TL;DR: The prevalence of transfusion-transmissible infection markers in donors at a hemotherapy service located in southwest Bahia, Brazil showed that 3.13% of the donors were considered unsuitable for serological screening and that the prevalence of reactive test results was higher in donors aged between 30 and 39 years and in males.

TL;DR: The present study shows that shortened prothrombin time, activated partial thromboplastin time and increased fibrinogen levels might be useful hemostatic markers in diabetic patients, especially in those at high-risk forThrombotic complications.

TL;DR: Patients with chronic myeloid leukemia should be advised to achieve a stable and deep molecular response if they plan to conceive, to avoid the risk of disease progression.

TL;DR: A growing number of young women suffering from malignant and benign hematological diseases are receiving allogeneic hematopoietic stem cell transplantation with very satisfactory results in relation to the disease itself, but these patients face gynecological problems due to graft-versus-host disease.

TL;DR: Participation in a distance education course on sickle cell disease had a positive impact on the acquisition of knowledge about the disease by professional healthcare providers.

TL;DR: Data confirm that the CD9 expression could be used for risk stratification in clinical practice and a strong association was observed between the level of CD9expression and the presence of ETV6-RUNX1.

TL;DR: The results corroborate the importance of cytogenetic abnormalities as a prognostic factor and indicate the need for cooperative and prospective studies to evaluate the applicability of the WHO classification in the pediatric population.

TL;DR: A clear deficit in the knowledge of transfusion medicine was verified, indicating the need for change in the teaching of this specialty in developed countries.

TL;DR: The critical outcome observed in relapsed, intolerant or refractory chronic phase CML patients reflects the unmet need for this group of patients without an alternative therapy, such as new drugs or experimental therapies in clinical trials.

TL;DR: Infections are a notable cause of morbidity and mortality in the clinical course of MM patients, and a risk-adapted selection of the MM treatment should be employed, with special attention toward patient age and disease-associated organ dysfunction.

TL;DR: The lack of evidence for a true risk profile for male-male sex in the context of blood donation upon which to base sound policy is highlighted, and research is recommended to establish effective and acceptable criteria for blood donation by MSM and other blood donors.

TL;DR: Regular follow-up is required to identify the causes of anemia not related to CML or imatinib toxicity, especially in patients with good adherence to treatment and satisfactory therapeutic response.

TL;DR: This review verified the existence of a higher prevalence of hemorrhagic symptoms in the HC, however, due to the limitations of the few studies found, there is still insufficient evidence to state that the HC has a greater hemorrhagic tendency in relation to the general population.

TL;DR: Primary immune thrombocytopenia (ITP) is an immunemediated acquired disease characterized by a transient or persistent isolated decrease in the platelet count and, depending upon the degree of throma, an increased risk of bleeding.

TL;DR: Additional risk factors noted include peripheral blood stem cell (PBSC) transplantation, unrelated, and increasing human leukocyte antigen (HLA) disparity between recipient and donor also appears to increase the risk of developing GVHD.

TL;DR: The adherence found in this study was similar to that found in others of its kind, which can reflect the need to individually educate Chronic Myeloid Leukemia patients.