Showing papers in "Hepatology in 1987"

TL;DR: To investigate the natural history of compensated cirrhosis, 293 consecutive patients without previous major complications were studied in terms of morbidity and survival and a prognostic index was constructed that allows calculation of the estimated survival probability.

TL;DR: Sixty‐five patients with histologically proven chronic active hepatitis of unknown cause but associated with the antiliver/kidney microsome antibody type 1, confirmed by immunofluorescence and immunoprecipitation, were selected as forming a special entity.

TL;DR: The prevalence of gallstone disease (cholelithiasis and previous cholecystectomy for gallstones) in the population of Sirmione, Italy, examined by ultrasonography, was 6.7% in men and 14.6% in women, ranging from 18 to 65 yr of age.

TL;DR: The qualities of simplicity, availability, low cost and good discriminating power for a life or death outcome make the Pugh score a very useful method to estimate prognosis in patients with cirrhosis.

TL;DR: It is concluded that fat‐storing cells are a major cellular source of dermatan sulfate and chondroitin sulfate in liver connective tissue and the formation of glycosaminoglycans as complex proteoglyCans is suggested.

TL;DR: It is recommended to base the diagnosis of acute vanishing bile duct syndrome on documentation of severe ductopenia in at least 20 portal tracts which may require several consecutive needle biopsies and no qualitative differences between acute reversible and irreversible rejection are found.

TL;DR: This thesis proposes that integration of HBV DNA into host chromosomes in acute or chronic hepatitis or during the "healthy" carrier state corresponds to an initiation event similar to that described in chemical carcinogenesis.

TL;DR: The data support the idea that binding of acetaldehyde to proteins in humans generates antigenic determinants which trigger a corresponding immune response against such epitopes and suggest that this humoral immune response may be implicated in autoantibody formation and liver damage associated with excessive alcohol consumption.

TL;DR: The effects of several treatments involving α‐adrenergic mechanisms upon the early stages of rat liver regeneration were examined and catecholamine concentrations in rat plasma were found to be elevated relative to those in plasma from sham‐operated rats.

TL;DR: A significant reduction of porosity as shown in this study may influence the blood hepatocytic exchange and contribute to the alcohol‐induced liver injury.

TL;DR: Heavy diffuse bleeding from congested gastric mucosa (congestive gastropathy) was treated by propranolol in 14 consecutive patients with portal hypertension and no patient has rebled from congestive Gastropathy while receiving propr ethanol during follow‐up of 12 to 42 months.

TL;DR: In a randomized controlled trial, 41 chronic hepatitis B virus carriers were allocated, by opening numbered computerized randomization envelopes, to receive recombinant interferon‐α2A at three different doses: 2.5; 5.0, and 10.0 mU per m2.

TL;DR: Acute exacerbations of disease occurred more frequently in HBeAg‐positive patients than in anti‐HBe positive patients with chronic type B hepatitis, but the clinicopathological features and etiologies were similar.

TL;DR: The electron microscopic morphology of the brain is reported in the same model of acute hepatic failure following the intravenous injection of horseradish peroxidase, an intravascular tracer which forms an electron‐dense reaction product.

TL;DR: It is concluded that while liver biopsy is a useful diagnostic tool in selected patients with AIDS, the information provided by biopsy rarely influences therapy or leads to improved survival.

TL;DR: Serial use of quantitative liver tests allows prediction of time of death from cirrhosis in this model.

TL;DR: Prostaglandin E1 not only inhibited the activation of liver adherent cells and suppressed the release of the cytotoxic factor, but it also directly affected the hepatocytes and protected them from the cyttoxic factor.

TL;DR: The results indicate that the cysteinyl leukotrienes are physiological substrates of the can‐alicular transport system for organic anions such as dibromosulfophthalein.

TL;DR: Isolated rat hepatocyte couplets, consisting of two hepatocytes enclosing a canalicular space, have been proposed as a primary secretory unit that may be useful for direct studies of unmodified canalicular bile secretion and their structural characteristics and plasma membrane reorganization are examined.

TL;DR: It is concluded that liver transplantation can be applied successfully to the difficult clinical problem of fulminant and subacute hepatic failure and survival rate for transplanted patients was significantly improved as compared to those not transplanted.

TL;DR: To determine whether bone loss in patients with chronic cholestatic liver disease is the consequence of a high or low bone turnover state, 30 female patients with biopsy‐proven primary biliary cirrhosis underwent iliac crest biopsy following double tetracycline labeling.

TL;DR: Different Class II antigens to be associated with a prognostic indicator in primary biliary cirrhosis (serum bilirubin), while HLA‐DRw8 is strongly associated with the disease itself.

TL;DR: It is concluded that endoscopic sclerotherapy is a good alternative to splenorenal shunt in the elective treatment of esophageal variceal bleeding, especially in patients prone to develop hepatic encephalopathy.

TL;DR: Mutant rats with abnormal hepatic excretory function were used to study biliary transport of dibromosulfophthalein, ouabain, tributylmethyl ammonium, cholate and taurocholate and confirmed that multiple pathways exist for the hepatobiliary excretion of organic anions, neutral steroids, bile acids and cations.

TL;DR: It is concluded that, in patients with cirrhosis, disproportional sedation after benzodiazepine administration may be due not only to impaired drug elimination, but also to hypersensitivity of the brain.

TL;DR: The study indicates that theδ‐agent may have the capacity to inhibit hepatitis B virus replication and that a chronic δ‐infection may lead to a termination of the period of active viral replication.